昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
37 巻 , 3 号
選択された号の論文の12件中1~12を表示しています
  • 小林 太刀夫
    1977 年 37 巻 3 号 p. 217-221
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
  • 鎌田 康夫
    1977 年 37 巻 3 号 p. 223-228
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The particular considerations were necessary to record the single unit neuron activity in deep structures of the brain in unanesthetized and unrestrained animals. However as in such past experiment, the holder of electrodes and micromanipulater system had been fixed on the cranial bone, so that the animals were under suffering unusual heavy weight on the head to maintain physiological posture and the recording of unit activity had been tend to limit in a definite neuron.
    To avoid these disadvantages, the special holder of synthetic resin with light weight was designed and the micro-insertion of electrodes was performed by means of oil pressing system which was situated in the out of animals. Furthermore, the position of holding electrode could be changed in some extent in this holder, so that it was possible to record the neuron activities in several parts of the brain stem in same animal and to record them for long time by selection of stable one from several neuron activities.
    Whenever the wanted unit activity was obtained, it was possible in this system to fix the electrode with dental cement for histlogical examination without disturbing another recordings.
    Among of several kinds of micro-electrodes, tungsten electrode was the most suitable for this system.
    As histological examinations, the frozen section method was best for comfirmation of the tip position of the electrode.
  • 渡辺 英男
    1977 年 37 巻 3 号 p. 229-242
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The vestibular equilibrium tests were performed for 67 cases of cerebral apoplexy with hemiplegia and all of them were compared with the cases diagnosed as vestibular lesion of the brain stem by the conventional method in order to examine what influences the supratentorial lesion has upon the vestibular and oculomotor systems of the brain stem.
    1. In 45 cases was observed the vestibular lesion of the brain stem.
    2. In total cases, percentages of cases showing nystagmus were as follows : gaze nystagmus, 35.8%; Frenzel's sitting nystagmus, 23.9%; positional nystagmus, 58.2%; and positioning nystagmus, 69.7%.
    3. In the gaze nystagmus test many cases showed bilateral direction, while in the positioal test, direction-fixed one.
    4. In the caloric nystagmus test canal paresis or something like that was observed in 18 out of 42 cases examined.
    5. Nystagmoid movement was found in many cases throughout the spontaneous, provoked, and caloric nystagmus tests.
    6. In the opto-kinetic pattern test (okp test) abnormal patterns were found in 44 cases with asymmetrical ones on both sides in 32 cases, almost all of which showed abnormal patterns on the paralytic side.
    7. In the vestibular equilibrium test no distinct difference was noticed between the right and left paralysis.
    8. When examined for right hemiplegia cases, aphasia was more frequently found in such cases as showed abnormal okp with remarkable asymmetry.
    In as high as about 80% of patients suffering from apoplexy, some abnormality or other was observed in the vestibular and oculomotor systems, indicating that the vestibular examination is useful for the diagnosis of central nervous disturbance in apoplexy.
  • 中神 和清
    1977 年 37 巻 3 号 p. 243-252
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Experimental allergic pancreatitis was induced in rats and guinea pigs by immunization with rat or guinea pig pancreas tissue emulsified in complete Freund's adjuvant containing 1 mg/ml Mycobacterium tuberculosis and also by injection of pertussis vaccine.
    By light microscopy, the lesion was characterized by in filtration of mononuclear cells in the periductal and perivascular area and also in the acinar tissue accompanied by the cellular necrosis and edema. However, no inflammatory lesion was found in Langerhans' islets. Development of the pancreatitis was observed at 10th day to 14th day after one shot immunization. On the contrary, no pathological abnormality was found in the pancreas of the animals received multiple immunization (6 times) with the pancreatic antigen.
    The sera of animals with the pancreatitis showed neither precipitating antibody, nor antibody fixing against frozen pancreatic sections detected by using the method of indirect immunofluorescence. The sera of animals received the multiple immunization with the pancreatic antigen showed the precipitating antibody against the pancreatic antigen. In addition, the sera showed the antibody fixing to cell membrane and cytoplasm of the pancreatic acinar (not to Langerhans' islets) detected by indirect immunofluorescence. The precipitating antibody was not absorbed with rat erythrocytes, liver, and serum. The antibody fixing with pancreatic tubular cells of rat did not react with the frozen pancreatic sections obtained from human, dog and rabbit.
    On the laboratory test, blood sugar level remained within normal range, however, the level of serum amylase was increased in some guinea pigs at 7th day after the immunization with pancreas of rat.
    These results suggested that the pancreatitis was developed not by humoral antibody, but by cellular immunity. The experimental allergic pancreatitis in rats and guinea pigs will be good model to elucidate the pathogenesis of human pancreatitis induced due to unk-nown causes.
  • 勝部 晋
    1977 年 37 巻 3 号 p. 253-262
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The reagin type of allergy and the hyperreactivity of air way play the important role in the etiology of bronchial asthma and it seems that the function of β-receptor is closely related to the both. Asthmatics and normal individuals were given Salbutamol as selective β2-stimulant and the changes of plasma cyclic AMP, lymphocyte cyclic AMP, blood sugar, blood pressure and blood eosinophils before and after administration of Salbutamol were evaluated. Cyclic AMP was measured by the method of protein binding assay.
    The following results were obtained.
    1) There were no significant differences in the plasma and lymphocyte cyclic AMP levels before administration of Salbutamol between asthmatics and normal individuals.
    2) The cyclic AMP levels and the blood sugar levels were increased and the minimum blood pressure and the number of blood eosinophils were decreased after administration of Salbutamol in asthmatics and normal individuals.
    3) Except the number of blood eosinophils and the blood sugar level, there were no significant differences at the rate of change in parameters of β-effect between asthmatics and normal individuals, but it seemed that asthmatics had a tendency of low rate of change as compared with normal individuals, so it was thought that there was the functional defect of 13-receptor in asthmatics.
    4) There were significant correlations between the changes of cyclic AMP level and the change of some other parameters of β-effect, but there was not the same tendency bet-ween asthmatics and normal individuals.
  • 辻 正富
    1977 年 37 巻 3 号 p. 263-272
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Studies were performed to investigate the influence of tolbutamide on the cyclic AMP system of the islets in the normal subjects.
    The conclusion were as follows;
    1) In the insulin response to the combined stimulation of tolbutamide and glucagon, which stimulates adenylcyclase, a synergistic effect was observed.
    2) The insulin response to glucagon was markedly enhanced by tolbutamide.
    3) Isoproterenol, which stimulates adenylcyclase, enhanced tolbutamide-induced insulin secretion
    4) Tolbutamide-induced insulin secretion was not enhanced by aminophylline which inhibits phosphodiesterase, but glucagon-induced insulin secretion was enchanced.
    5) From the results as above, it seems that tolbutamide inhibits phosphodiesterase in the B-cell of islets.
    6) In each experiments, the increase of C-peptide showed a close correlation with that of insulin, and C-peptide was considered significantly to reflect the insulin secretion.
    7) Peak levels of C-peptide occurred later than those of insulin and C-peptide decreased slowly to basal levels. The molar concentration of C-peptide were greater than insulin. Molar ratio (CPR : IRI) at peak levels was from 1.3 to 3.13.
  • 羅 昌平, 武重 千冬
    1977 年 37 巻 3 号 p. 273-277
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    家兎を仰臥位にしたり, 体に部分的な強圧を加えたり, 針電極を介して末梢に低周波刺激 (針刺激) を加えたりした時には, 互いに相似した特徴ある脳波変化が現われるが, この脳波変化の出現に体液性の因子が関与するか否かを, 交叉灌流実験から検した.
    2匹の動物で交叉灌流中, 供血兎に上記の操作を加えて特徴のある脳波変化が現われると, 受血兎にも程度は幾分減ずるが同じような変化が出現する.中脳水道の周辺組織がこのような脳波変化に関与する可能性を論じた.
  • 羅 昌平, 武重 千冬
    1977 年 37 巻 3 号 p. 279-286
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    家兎に慢性的に電極を植えこみ, 皮質下脳波を記録し, 動物を仰臥位にしたり, 体の一部に強圧を加えたり, 末梢に針電極を介して低周波刺激 (針刺激) を与えたりすると互いによく似た脳波変化が現われる.
    すなわち家兎の皮質下脳波は覚醒時θ波が基盤となっているが, これらの操作による初期の変化は脳波のリズムの減少, 振幅の減少で, 周波数分析した脳波ではθ波の減少となって現われる.その後, δ波の増大が出現する.睡眠脳波ではδ波の増大とθ波の減少とは一致して現われるが, 上記の状態ではθ波の減少が単独で出現する.
    仰臥位, 体の部分的強圧, 単調な刺激はすべて動物催眠を誘起する方法であるが, 仰臥位による動物催眠では動物はある時間経過した後起き上り, 脳波変化も覚醒波となって後効果は現われないが, 後の二者では刺激終了後も変化が持続する後効果が現われる.
    単調な刺激に属する針刺激では, 脳波の変化が現われるまでに数分の潜伏期を必要とする.この潜伏期は再度の刺激で短縮する.針刺激によって脳波の変化を来たすのには, 軽度の筋収縮を起こす程度の強さの筋刺激がもっとも有効であった.弱すぎたり強すぎたりしても脳波に変化は出現しない.
    中脳の中心部 (中脳中心灰白質及び近傍組織) を直接電気刺激するに, 上記の脳波変化と似た脳波変化が現われた.
    自己受容性の受容器及び中脳中心部を, このような共通の脳波変化を来たす機序として考察した.
  • 渡辺 浩之, 山口 修, 新田 増雄, 副島 和彦, 盛山 真行
    1977 年 37 巻 3 号 p. 287-291
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A case of cylindroma of the hard palate metastasizing to the lungs in a seventy nine years old man is described with clinical and postmortem findings. Some of hard palate tumors are also reviewed literaturely. Invasion to the perineural space and involvement of regional lymph nodes of tumor cells are not revealed. The survival time of this case is five years after plumonary metastasis was found.
  • 石橋 守正, 友安 茂, 布上 直和, 横山 新一郎, 浅野 洋治, 鶴岡 延熹, 渡辺 浩之, 太田 秀一, 杉山 喜彦, 風間 和男
    1977 年 37 巻 3 号 p. 293-300
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The leukemic reticulosis is a disease with acute process and its unknown reality. The two cases described in this paper.
    Case 1. A 64 year old woman. On admission, the white blood cell count was 84, 800/cmm with 77 per cent reticulum cells. She presented with swelling of lymph nodes and enlargement of spleen, both of which revealed proliferation of reticulum cells. The frequency of tumor cells was as low as 1.2 per cent in bone marrow. This case could possibly be identified as reticulosis originated from lymph nodes or spleen.
    Case 2. A 20 year old woman. On admission, the white blood cell count was 1, 500/ cmm with 86 per cent reticulum cells. Proliferation of reticulum cells were noted in bone marrow and spleen, but no remarkable proliferation were noted in lymph nodes. This case was suspected that these abnormal cells were originated from spleen on autopsy findings.
    In both cases, these cells were positive for acid phosphatase reaction, and its morphological and cytochemical findings also indicated characteristics of leukemic reticulosis.
  • 内田 伸昭, 吉田 和政, 佐藤 元助, 仁木 寛, 長村 洋, 持丸 賢二, 押川 紘一郎, 細山田 明義, 曽根田 靖昭
    1977 年 37 巻 3 号 p. 301-304
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A 3-year-old boy with renal tumor underwent right nephrectomy under N2O-O2-halothane anesthesia. Sudden and unexpected death occurred during operation and all atte-mpts at resuscitation failed.
    The cause of desth in this case was suggested that a massive pulmonary embolus of tumor tissue presumably had been dislodged from the inferior vena cava.
  • 時田 信仁, 長野 治啓, 藤森 師雄, 岡 嗣郎, 馬渕 春樹, 渡辺 悟郎
    1977 年 37 巻 3 号 p. 305-308
    発行日: 1977/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Two cases of pendulous tonsils in elderly patients such advanced age as 85 and 69 years of age are reported.
    So far the available literaures up to date are concerned, no case has been reported yet such advanced age as 85 year old patient.
    Tonsillectomy was performed without any problems or complications and postoperative clinical condition was excellent. Foreign body sensation of throat, dysphasia and dysarticula-tion existed no more than the time of operation.
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