昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
39 巻, 4 号
選択された号の論文の15件中1~15を表示しています
  • 北原 隆, 横田 朝男, 小松 隆, 菱田 豊彦, 岡部 文夫
    1979 年 39 巻 4 号 p. 361-364
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    On the radiotherapy planning for brain and nasopharyngeal tumor, we have taken usually computed tomogram on the level of the lesion and enlarged this film to the same size of the patient.
    On the other hand, dose distribution curve was made by PDI-10 (photographic method for measuring dose distribution) and Rando Phantom.
    It is avairable to consider that the enlarged CT film is piled up on this dose distribution curve for radiotherapy planning.
  • 佐藤 元助
    1979 年 39 巻 4 号 p. 365-372
    発行日: 1979/08/28
    公開日: 2010/11/19
    ジャーナル フリー
    Present experiment is concerned with the effects of hemorrhage and re-transfusion of shed blood on the unit activities of antidromically identified neurohypophysial neurosecretory neurons in SON of 36 adult male Wistar rats under denervation of the vagus and/or the carotid sinus nerves.
    The firing rates in 5 of 12 units were increased, in 6 were not changed and in 1 unit were decreased in intact rats by hemorrhage which reduced the arterial systolic pressure to 50 % of prehemorrhagic pressure. Re-transfusion reversed the changes of firing rates due to hemorrhage, i. e. increased 5 units by hemrrhage except one showed decrease of firing rates and unchanged 6 units remained unchanged by re-transfusion.
    Under bilateral vagotomy, firing rates of all examined 7 units were not changed by hemorrhage and re-transfusion.
    Under denervation of carotid sinus nerves, hemorrhage did not cause any detectable changes in firing rates in 6 of 7 units and increased firing rates in 1 unit. 4 of unchanged 6 units during hemorrhage remained unchanged during re-transfusion.
    Under both bilateral vagotomy and denervation of carotid sinus nerves, firing rates of all examined 4 units did not change by both hemorrhage and re-transfusion.
    Those results implied that two types, one is responsible for hemorrhage and the other is not responsible for it, existed in neurosecretory neurons of SON, and that neural information in both vagus and carotid sinus nerves played an important role for neurohypophysial secretory mechanism in SON.
  • 第1報.健康小児における赤血球2, 3-Diphosphoglycerateの検討
    城之内 治美
    1979 年 39 巻 4 号 p. 373-379
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    The levels of erythrocyte 2, 3-diphosphoglycerate (RBC 2, 3-DPG) were determined by end-point method (UV test, Boehringer Mannheim) . Fifty five healthy children ranging from two and half months to 15 years of age were studied on the RBC 2, 3-DPG levels and 18 low-birth-weight (LBW) infants were also participated. The mean value and standard deviation of RBC 2, 3-DPG in healthy children were 5.43±0.29μmol/mlRBC. No significant difference was detected in age and sex. Also the value of 2, 3-DPG was not significantly different from those of 10 healthy adults determined by the same method.
    In neonatal period, it has been suggested that blood O2 affinity correlated well with the effective 2, 3-DPG fraction (EDPG) because of high concentration of fetal hemoglobin. Daily changes of EDPG in 18 LBW infants were studied after birth. Within one week of age, EDPG levels showed about 40 per cent as compared with those of healthy children, increasing gradually thereafter which did not reach within normal range by one month.
  • 木村 忠直, 伊藤 良作, 佐藤 亨, 佐藤 巌
    1979 年 39 巻 4 号 p. 381-388
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    In order to clarify the characteristics of myofibrous organization in the skeletal musculature of primates, M. tibialis anterior of adult crab-eating monkeys (5 males and 5 females) was investigated, differentiating into 3 type of muscle fibers by Sudan-Black B staining method. Following results were obtained.
    1. Though the sex differences in body weight of materials was not seen, the muscle weight and the thickness of muscle fibers were greater in males, and the cross-sectional area of venter, the number of muscle fibers per sq. mm. and the total number of muscle fibers were greater in female.
    2. In the 3 type of muscle fibers, white fiber were highest in about 50%, red fiber second most and intermediate fiber least. But there was a few case in female which hadn't significant differences between red and intermediate fibers or was predominant in intermediate than in red fiber.
    3. Concerning the distribution of the 3 type of muscle fibers in the cross-sectional area, white fiber was predominant in lateral 1/3, red fiber in medial 1/3 and intermediate fiber in middle 1/3. And the border line of these area was lenient.
    4. The thickness order for 3 type of muscle fiber was always ; largest, white ; then intermediate ; and red, smallest. All three of these types were larger in male than in female, and this tendency was predominant on the larger group of body weight.
    5. Comparing the crab-eating monkey and the rat, the distribution pattern of three type of muscle fiber in the cross-sectional area and the thickness of muscle fiber were similar in both and the total number of muscle fiber were in proportion to body weight in both, and the ratio of white fiber were predominant than in rat. From these facts, it is considerd that the M. tibialis anterior of monkey is more phasic in function than in rat.
  • 許 根元
    1979 年 39 巻 4 号 p. 389-395
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    牛肝臓homogenateに含まれるMAOの凍結保存中における安定性について検討した.MAO活性の測定にはMcEwenのbenzylamine法を一部改良して用いた.牛肝臓より0.25M sucrose, 純水にて1, 000倍の希釈度のhomogenateを作製し, -20℃にて1週間凍結保存した場合にはMAO活性に何ら変化は認められなかったが, これを生食で作製した場合には著しい失活が認められた.この生食に0.01Mのphosphate buffer (pH6.1, 7.4) を組合せた場合には更に失活が強くなり, 逆に0.25Mのsucroseを組合せると失活は認められなかった.この生食による凍結保存中のMAOの失活はhomoge-nateの希釈度によって異なり4倍, 10倍の希釈度では失活は起らず, 100倍の希釈度になると約40%, 1, 000倍の希釈度になると約80%の失活が認められた.この生食によるMAOの失活は牛脳homogenateの場合でも同様に認められたが, 牛血清MAOの場合には影響は認められなかった.このMAOの失活にはpH (5.5~8.0) の影響は認められなかった.このMAOの失活度は用いた食塩の濃度によって大きく相違し, 0.03%までは影響が認められなかったが, 0.1%で約50%, 0.3%で75%, 1%で85%の失活が認められた.この生食によって凍結保存中に起きたMAOの失活は1夜透析しても全く回復しなかった.
  • 岡 潔
    1979 年 39 巻 4 号 p. 397-407
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    1.ラットの尾部の傷害光熱刺激による, 尾逃避反応の潜伏期を痛覚閾として, 針麻酔式刺激を加えると, 潜伏期の増加, すなわち針鎮痛が現われる動物が見い出された.
    2.動物によって針鎮痛の現われる動物と現われない動物があり, 5%以下の危険率で有意の差のある針鎮痛が現われる動物を針鎮痛有効群, 現われない動物を無効群とすると, 有効群はほぼ半数であった.
    3.針鎮痛有効群の動物の中脳中心灰白質に直径0.5mmの電極を挿入すると, 針鎮痛は全く出現しなくなった.
    4.挿入された電極を介して電気刺激を中脳中心灰白質に加えると鎮痛が現われたが, 中脳水道に面した部分の刺激によって, もっとも強い鎮痛が現われた.
    5.中脳中心灰白質に電極を挿入しても痛覚の閾値には有意の差のある変化は現われなかった.
    6.中脳中心灰白質を電気破壊すると針鎮痛は消失した.また痛覚の閾値には変化がみられなかった.
    7.中脳中心灰白質に電極を挿入すると針鎮痛が消失するが, 中脳中心灰白質を電気刺激した後, 僅かに針鎮痛が回復する傾向がみられたが, これは有意の差のある変化ではなかった.
    8.針鎮痛出現中, 10mg/kgのnaloxoneを投与すると, 針鎮痛は部分的に拮抗された.
    9.中脳中心灰白質破壊による針鎮痛消失の機序を4つの可能性から論じた.
    本論文の要旨は, 第54回日本生理学大会 (昭和52年4月6日) .Second World Congress on Pain (1978年8月29日) で報告した.
  • 羅 昌平, 田中 正明, 瀬川 克己, 武重 千冬
    1979 年 39 巻 4 号 p. 409-412
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    1.ラットの中脳中心灰白質に直径0.4mmの電極を挿入すると, 針麻酔式刺激によって現われる鎮痛も, 0.5mg/kgのモルヒネの投与によって現われる鎮痛もともに減弱し前者では殆んど消失し, 後者では極度に減ずる.
    2.針鎮痛よりやや強い程度の中脳中心灰白質の刺激によって現われる鎮痛はモルヒネの拮抗剤であるnaloxone 1mg/kgの投与によって消失する.
    3.針鎮痛の出現には中脳中心灰白質が関与し, かつ, 鎮痛の発現には脳の内因性モルヒネ様物質が関与することが示唆された.
  • 村居 真琴, 羅 昌平, 清水 比登実, 藤下 悌彦, 武重 千冬
    1979 年 39 巻 4 号 p. 413-417
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    1.ラットの尾逃避反応の潜伏期を痛覚の閾値とした針麻酔式刺激によって現われるいわゆる針鎮痛は, 個体によって差異があり, 5%の危険率で有意の差のある鎮痛の出現の有無によって, 針鎮痛有効群と針鎮痛無効群に分けることが出来る.
    2.0.5mg/kgのモルヒネの投与によって現われる鎮痛は, ほぼ針鎮痛と同程度であるが, この濃度によって現われるモルヒネ鎮痛にも個体差があり, しかも針鎮痛有効群はモルヒネ鎮痛も有効で, 針鎮痛無効群はモルヒネ鎮痛も無効であった.針鎮痛の表示である尾逃避反応の潜伏期の増加率と, モルヒネ鎮痛のそれとの間には, 相関係数0.75の相関関係がみられた.
    3.PAGのほぼ定位置に一定電流を与え現われる鎮痛にも個体差がみられ, やはり, 針鎮痛有効群では鎮痛がよく現われるのに反し, 針鎮痛無効群では鎮痛が現われ難かった.
    4.針鎮痛の有効性の個体差には脳内のMLFの含有量のみならず, その他の要因も関与することが示唆された.
  • Reserpine胃潰瘍における胃壁中のMAO活性とserotoninおよびnoradrenaline含量の関係
    深田 潤
    1979 年 39 巻 4 号 p. 419-425
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    Effects of reserpine, iproniazid and 6-hydroxydopamine (6-OH-DA) on monoamine oxidase (MAO) activity and on serotonin-and noradrenaline-contents in rat brain, liver and stomach, both in vitro and in vivo, were investigated and the following results were obtained.
    (1) An intraperitoneal injection of reserpine in rat resulted in a significant increase in MAO activity after 24 hours in brain by 120% of the control with serotonin as substrate, but no change in activity with tyramine as substrate. On the other hand, liver MAO activities both with serotonin and tyramine as substrate were not changed by reserpine pretreatment. (2) Reserpine showed a slight inhibition of MAO activity in rat stomach, in vitro, with benzylamine as substrate. (3) Pretreatment with 6-OH-DA did not cause any change in MAO activity in brain but with combination of 6-OH-DA and iproniazid, MAO activity was inhibited strongly. However, MAO activity in stomach was reduced with the all pretreatment mentioned above. (4) With reserpine pretreatment, serotonin in brain disappeared almost completely, but it resulted in a slight incraese of 112% of serotonin content in stomach. With iproniazid pretreatment, serotonin content resulted in 278% and 168% increase in brain, and in stomach, respectively. With combination of reserpine and iproniazid, serotonin content was reduced by 83% in brain, but was increased by 147% in stomach. Similarly, with 6-OH-DA pretreatment, serotonin content was reduced by 88% in brain, but was increased by 156% in stomach. With the combination of 6-OH-DA and iproniazed, serotonin content was increased by 164% in brain and by 135% in stomach. (5) With reserpine pretreatment, noradrenaline content was reduced almost completely both in brain and stomach. With iproniazid pretreatment, noradrenaline content was incre ased by 245% in brain, and by 171% in stomach, but with combination of reserpine and iproniazid, it was reduced almost completely both in brain and stomach. With 6-OH-DA pretreatment, noradrenaline content was reduced remarkably both brain and stomach. Furthermore, with combination of 6-OH-DA and iproniazid noradrenaline content was reduced by 63% in brain, and was reduced almost completely in stomach. (6) Clearly ulcers in rat stomach 24 hours after pretreatment with reserpine or with combination of reserpine and iproniazid were found.
  • ―海産カキ細菌汚染機構の解明―
    尾藤 朋子
    1979 年 39 巻 4 号 p. 427-443
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    Since oysters have been a cause of the outbreak of enteric infectious deseases in many countries because they are customarily relished as fresh dishes, the bacteriological sanitary control of oysters in the growing area is one of the most important problems in the food sanitation field.
    This article is designed to investigate the mechanism of bacterial contamination of the living Japanese oysters (Ostrea gigas, THUNBERG, obtained at the Hiroshima Bay) by means of laboratory experiment.
    However, these experiments are complicated and very difficult to carry out by the traditional bacteriological techniques, because, for example, ordinary oysters are heavily contaminated with various bacteria and then it is impossible to detect and measure the bacteria which have been newly added for tracing out the behavior of those accumulated in the oyster. In this study, therefore, introduction of the bacteria labeled with a suitable radioisotope into the experimental system was examined to solve the above difficulty.
    Colon bacteria (E. coli), a useful bacterial indicator of fecal contamination of foods, were examined for labeling with two radioisotopes, i.e. β emitter 90Y and γ emitter 203Hg. The special merits of the both nuclides are as follows ; 90Y is the short living and safe daughter of 90Sr, which can be readily separated from 90Sr whenever necessary, and 203Hg has high affinity to bacterial cells and the activity in materials can be easily measured without special sample preparation.
    As an experimental result, the most suitable labeling conditions were as follows ; mix the washed bacterial cells and the RI solution and stand for 30 minutes at room temperature, and then wash. the cells once or twice in a centrifuge.
    In case 1 mCi/ml of RI solution was reacted by means of this method to the bacterial mass (corresponding to 5 ml of the broth cultivated for about 20 hours), the bacteria labeled with about 10-3 cpm for 90Y or 1 cpm for 203Hg per cell can be prepared respectively. It was confirmed that radioactivity labeled to bacteria was stable in sea water.
    Experimental studies on the contamination mechanism of living oysters using the above radio-labeled colon bacteria were as follows ; the shellfish was reared in the artificial sea water in aqualium vessel to which had been added suspension of the labeled bacteria. The radioactivity of the oyster, i.e. the bacterial number accumulated in the shellfish, was measured with the samples which have been asked by the wet method for 90Y or in a fresh intact form for 203Hg.
    The obtained results are as follows ; the radioactivity of the oyster increased exponentially up to about 20 hours after, and then reached equilibrium. As for the effect of rearing water temperature (ranging 10°C-28°C), the bacterial accumulation of oyster increased according to the increase of the temperature, although within the temperature ranges under 10°C or above 28°C (up to 35°C) the increase was little. However, it was observed that the oyster was contaminated with colon bacteria even at the coldest temperature as low as 3°C.
    As the salinity of the rearing water reduced, the bacterial up take rate of oysters decreased to a considerable degree, especially in fresh water no uptake was observed at all. This result distinctly differs with the traditional theory.
    It was determined that the bacterial burden of oysters depended mainly on the contamination of the gill, however, the contamination of the digestive tract was not negligible.
    When the contaminated rearnig water was continuously supplied by flowing, the uptake rate of the oyster was as about double as those in the case of rearing under a closed condition.
  • 砂田 英二, 篠塚 明, 高橋 吉政, 徳永 宏司, 田崎 功, 山ノ口 俊之, 北原 隆, 菱田 豊彦
    1979 年 39 巻 4 号 p. 445-448
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    Three cases of unsuspected liver accumulation of 99mTc-EHDP were found in 72 cases of bone scintigram.
    It is suggested that a mechanism of this liver accumulation depends on colloid formation of 99mTc-Sn-compound by Al _??_ elution from alumina column. We have found by these animal experiments that the more increasing of Al _??_ elution, the more accumulation in the liver.
  • 山城 元敏, 高場 利博, 堀 豪一, 太田 宏, 石井 淳一, 堤 健, 春見 建一
    1979 年 39 巻 4 号 p. 449-453
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    A 52-year-old male, with episodes of dizziness, temporal loss of consciousness and weakness of the left arm was successfully treated by the carotid-subclavian bypass surgery with the use of supraclavicular approach. The surgical treatment of subclavian steal syndrome was discussed.
  • 清水 敬介, 李 中仁, 川内 章裕, 河村 一敏, 東 弘志, 帆刈 睦男, 荒井 潔, 高尾 資朗, 善山 金彦, 安藤 彰彦, 佐藤 ...
    1979 年 39 巻 4 号 p. 455-459
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    A primary advanced breast carcinoma occurred in a 46-year old woman who had been taking oral contraceptives for twelve years. She was treated by radical mastectomy and bilateral oophrectomy. Histologically, the breast lesion showed scirrhous carcinoma. She became aware of an enlarging nodule in the outer upper quadrant of the right breast six years before admission. The low back pain radiating to the right leg began two months before admission. On admission X-ray film showed metastatic osteolytic figure to the right ilium. After the surgical operation, the pain was relieved and the follow up X-ray film showed improvement of the metastatic lesion of the ilium. She is alive well for two years after the operation.
    We suppose that oral cotraceptives made the condition worse in this case. So that, careful observation should be made in the woman taking oral contraceptives.
  • 栗山 節郎, 小谷 貢一, 福沢 啓一, 木村 恒雄, 宮岡 英世, 関 英正, 丸山 俊章
    1979 年 39 巻 4 号 p. 461-464
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    The bone and joint tuberculosis is decreasing recently, because of the development of chemotherapy and preventive medicine. But it is not rare. The recently experienced cases, especially in their early stage, are very difficult to differenciate from primary tumor or metastatic tumor. We report about four cases of recently experienced bone and joint tuberculosis.
    Case 1. A woman aged 38 had right chest pain. The 6 th and 7 th rib and chest tumor excision was performed.
    Case 2. A woman aged 59 had a tumor of the back. Excision of the 11 th rib was performed.
    Case 3. A woman aged 53 had a right chest pain. Excision of tumor of the 6 th rib was performed.
    Case 4. A woman aged 45 had a lumbago and tumor in left thigh. Excision of the tumor was performed.
    We conbined operation and chemotherapy to all cases, and we got good results.
  • 石井 英一, 値賀 正章, 渋谷 正直, 本田 公夫, 松崎 史郎, 稲田 豊
    1979 年 39 巻 4 号 p. 465-468
    発行日: 1979/08/28
    公開日: 2010/09/09
    ジャーナル フリー
    A 39-year-old man was operated for the rupture of gastric and esophageal varices under anesthesia with nitrous oxide, oxygen and halothane, tachycardia and hypotension were occured during the surgical operation.
    However, just after the operation, closed pneumothorax was diagnosed by the chest X-ray examination.
    From this case, we recognized the importance of taking chest X-ray films prior to an emergency operation and the necessity of suspecting pneumothorax in the presense of a reflactory fall in PaO2 during general anesthesia.
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