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Volume 41 (1981)
- Issue 6 Pages 619-
- Issue 5 Pages 481-
- Issue 4 Pages 353-
- Issue 3 Pages 227-
- Issue 2 Pages 117-
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Volume 41, Issue 4
Displaying 1-16 of 16 articles from this issue
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—WITH SPECIAL REFERENCE TO CLINICAL SYMPTOMS AND INTRAVENOUS GLUCOSE TOLERANCE TEST—Kikuko KOJIMA, Tadao FUJIMAKI, Yasuhiko SHIOHARA, Masaki KOBAYASHI, Hi ...1981 Volume 41 Issue 4 Pages 353-365
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThree hundreds and nine patients (male 234, female 75) with acute myocardial infarction were divided into two groups of diabetes and non-diabetes for comparative studies on their clinical features. Intravenous tolerance tests were performed on 39 patients in the acute stage of myocardial infarction for evaluation of glucose tolerance.
The complication of diabetes mellitus was seen in 32.4 percent of all of the infarcted patients, and this value was almost the same either in male or in female patients. In the female infarcted patients, the olders were more frequently affected by diabetes mellitus than the youngers. Twelve percent of the diabetic group had painless infarction and this was significantly higher compared with that of the non-diabetic group. 43.5 percent of the diabetic female patients showed atypical symptoms such as painless attacks. Among the diabetic group under the age of 60, 25.8 percent had initiated the disease with atypical symptoms including painless infarction. Complications with congestive heart failure were found in many of the female diabetic group, as high as 43.4 percent in Killip III and IV groups. And the younger diabetic patients had the higher incidence of congestive heart failure compared to the non-diabetic group. In the diabetic group, 73.3 percent of the deaths were due to congestive heart failure in the acute stage.
The intravenous glucose tolerance test exhibited that the blood sugar levels both before and after loading were higher in the diabetic group than in the non-diabetic group, while the K-value (glucose disappearance rate) was significantly lower in the diabetic group than in the non-diabetic group. With Fisher's discriminate function, the K-value was better than the blood sugar itself. When the discriminate function due to the K-value was established, the critical value was 0.85. With the K-value, diagnosis of diabetes mellitus will be in more possible than 80 percent of the cases in the acute stage of myocardial infarction.View full abstractDownload PDF (1554K) -
Akira SHINOTSUKA1981 Volume 41 Issue 4 Pages 367-381
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSarcoma 180 cells were implanted in C3H/He mice and blastogenic responses (PHA, Con A, LPS) of spleen cells were observed time serially to determine the relationship with concomitant immunity. Blastogenic responses dropped markedly in the early phase after implantat due to immunosuppression from the tumor, but they later recovered to a certain level. Product of the cpm value for PHA response and the spleen cell population (the number of cells responsive to PHA) showed a close correlation with concomitant immunity (resistance towards tumor) . Concomitant immulity was established when the value became 1.5-fold the normal. The correlation of the two became even more definite by the implantation study following whole body irradiation. When the regression of tumo mass was brougt about by irradiation, cells responding to PHA maintained a high lewel for a long time. The resietance towards tumor was also maintained prolongedly. Contrarily, when the tumor was resected, the PHA responding cells decreased rapidly and the resistance towards tumor also vanished quickly. For the maintenance of resistance against tumor, the inactivated tumor cells should be retained in the body for long and irradiation was favorable to this end. Relationship between blastogenic responses and spleen cell population is also associated with this phenomenon.View full abstractDownload PDF (1680K) -
Shizen ISHIKAWA, Kazuo OKUYAMA, Atsuyoshi TAKAO, Katsuhiko TATSUNO, Ma ...1981 Volume 41 Issue 4 Pages 383-392
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is well known that copal ventricular septal defect may be associated with prolapse of the aortic cusp, and subsequent aortic regurgitation. Several papers have documented the clinical, angiocardiographic, and surgical features of this association. It is obviously of importance to detect the conal ventricular septal defect prior to the occurence of significant aortic regurgitation. In the past few years, we have found that phonocardiography has proven useful in the early detection of aortic cusp prolapse with the natural history of conal ventrucular septal defect as suggested in the small series studied by Farru and associates. It is the purpose of this report to more fully document our experience with phonocardiographic recordings in 30 patients with aortic valve prolapse with conal ventricular septal defect. (CVSD)View full abstractDownload PDF (6680K) -
II: EFFECT OF STATIONARY INSERTION ON THE CONTRACTION RECOVERY PROCESS FOLLOWING TETANUSHaruto KINOSHITA1981 Volume 41 Issue 4 Pages 393-403
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSContraction of gastrocunemius muscle in guinea pig and frog was reduced following tetanic stimulation to the muscle for 15 minutes in situ. A comparison of electrode inserted muscle and non-inserted muscle was made to assess the recovery process from reduced contraction. The recovery process in electrode inserted muscle was more remarkably facilitated than in non-inserted muscle.
This facilitatory effect of electrode insertion on recovery from a reduced state after tetanic stimulation began immediately after electrode insertion, reached a peak at 2 hours and continued for more than 5 hours. This effect still appeared after lesions of the cerebral cortex, spinal cord and sciatic nerve, and was induced after ligature of the femoral artery and vein for 3 hours. The effect was abolished following administration of atropine or capsaicine.
It can be assumed that the facilitatory effect of electrode insertion on the recovery process in tetanized muscle might be attributed to the vasodilation caused by the axon reflex within the muscle.View full abstractDownload PDF (2396K) -
III: EFFECT OF ACUPUNCTURE IN RECOVERY FROM REDUCED MUSCLE CONTRACTION OF TETANIZED MUSCLE AND ITS CORRELATION WITH CONDITIONS OF ACUPUNCTURE NEEDLINGHaruto KINOSHITA1981 Volume 41 Issue 4 Pages 405-409
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDenervation of guinea pig gastrocunemius muscle two weeks prior to testing suppressed acupuncture facilitation of recovery from tetanic stimulation. This result agreed with our previous conclusion that acupuncture facilitation of tetanized muscle recovery is due to an axon reflex effect.
Using the above observations as criteria, the effects of various acupuncture procedures were examined. Acupuncture was effective if the needle was inserted 10 mm, but at 3 mm depth. The use of one or three needles made no difference in the acupuncture effect. Recovery was facilitated by post-tetanic insertion of the acupuncture needle ; Whereas, pre-tetanic insertion produced no such effect.View full abstractDownload PDF (619K) -
Makoto AMANO, Yasuhiko KOMATSU, Mitsuru OKAZAKI, Tomoko OKAZAKI, Haruo ...1981 Volume 41 Issue 4 Pages 411-419
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe influences of schizophyllan (SPG) and various kinds of antitumor agents on the delayed cutaneous hypersensitivity test with picryl chloride were examined.
1. Influence of alkylating agents : Among cyclophosphamide, carboquone and thio-TEPA, cyclophosphamide and carboquone inhibited delayed-type hypersensitivity (DTH) . The inhibition could not be recovered by treatment with SPG.
2. Antimetabolites : Among cyclocytidine, cytosine arabinoside, methotrexate, 6-mercaptopurine, azathioprine, 5-fluorouracil and futraful, methotrexate, 6-mercaptopurine, 5-fluorouricil and futraful inhibited DTH. The inhibition showed tendency towards recovery by the administration of SPG.
3. Antibiotics : Among adriamycin, actinomycin D, chromomycin A3, bleomycin and mitomycin C, only mitomycin C inhibited DTH. Inhibition could be recovered to normal levels by treatment with SPG. Bleomycin appears to stimulate DTH.
4. Alkaloids : No inhibition was observed in the cases of vinblastine and vincristine. Vincristine seemed to enhance DTH.
5. Steroid hormones : No influence was observed when cortisone, prednisolone and dexamethasone were administered.
6. Enzyme : L-Asparaginase showed no effect on DTH.
7. Immunopotentiating agent : Krestin enhanced DTH by intraperitoneal injection at a much higher dose (200 mg/kg) than that of SPG (2 mg/kg) .View full abstractDownload PDF (697K) -
Satoshi ONDA, Keiji IHARA1981 Volume 41 Issue 4 Pages 421-426
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSMasseter muscle fibers from the bellies of ten adult crab-eating monkeys (six females and four males) were studied to elucidate the characteristics of myofibrous organization in the masseteric muscle of monkeys. The muscle fibers were differentiated by Sudan Black B staining method into three types, termed white, intermediate and red fibers, with respect to fiber staining density. The following results were obtained : 1) The development of muscle weight, total number of muscle fiber and size of muscle fiber were positively correlated to development of body weight. This tendency was more marked among males than females. 2) Among the three types of fibers, the intermediate fiber was the largest in the percentage of muscle fibers in the whole section. The size of muscle fiber was greatest in the white, next the intermediate and the smallest in the red. Also, the size difference between the three types of muscle fiber was greater in males. 3) Compared with the myofibrous organization of tibialis anterior muscle and spinohumeral muscles in the same subjects, the masseter muscle was the smallest in size compared to other muscle fibers and in percentage of white muscle fiber.View full abstractDownload PDF (782K) -
Miki SHIBUSAWA, Shiro TACHIKAWA, Yohichi ITO, Kentaro KAMIYA, Genshich ...1981 Volume 41 Issue 4 Pages 427-433
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSExperimental conditions for a micromethod to test in vitro mouse spleen cell blastogenic response to Phytohemagglutinin (PHA) and Concanavalin A (Con A) was investigated. Mouse spleen cells revealed the maximum response to 20μg/ml PHA and 10μg/ml Con A on day 3 in culture in RPMI 1640 containing 10 % fetal-calf serum. Mouse spleen cell blastogenic activity, thus determined, increased in accordance with aging, until 25 weeks of age tested. In tumor-bearing mice, spleen cells exhibited the maximum response to PHA and Con A, 6 days and 8 days after tumor inoculation, respectively, and then decreased in accordance with the progress of tumor growth.
Mixed lymphocyte-tumor cell culture reaction (MLTR) was studied using the micromethod condition. The maximum response of spleen cells to Mitomycin C-treated syngeneic tumor cells was observed on the 5th day of culture, when the spleen cells were mixed-cultured with tumor cells in a ratio of 1 : 1. The micromethod described in this paper was show to be one characterized by highsensitivity and reproducibility.View full abstractDownload PDF (763K) -
Minoru HONDA1981 Volume 41 Issue 4 Pages 435-438
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is known that urninary β-aminoisobutyric acid (BAIBA) excretion levels increase after irradiation. Due to the fact that BAIBA is a catabolite of thymine derived from DNA, it is possible to indirectly determine thymine catabolism by measuring urinary BAIBA levels ; however, BAIBA is metabolized further in low BAIBA excretors, so it is not possible to conclude that BAIAB excretion levels reflect thymine catabolism. In addition, it is thought that low excretors can be managed, as well as high excretors, with antituberculotic cycloserine administration, inhibiting aminotransferase which metabolizes BAIBA. In a study of nuclear acid metabolism, particularly thymine catabolism, tumor bearing rats that were administered cycloserine, were irradiated. Their BAIBA excretion levels increased and excretion peak level was more remarkable than without cycloserine administration.View full abstractDownload PDF (437K) -
I. PERTUSSAL LYMPHOCYTOSIS INDUCED BY INTRATRACHEAL INFECTION IN MICESadatoshi TABAYASHI1981 Volume 41 Issue 4 Pages 439-444
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSMultiplication of bacteria in lungs and change in blood picture were investigated in the course of intratracheal infection with sublethal doses of B. pertussis in specified-pathogen-free mice. 1) After intratracheal inoculation of 107 bacteria, the viable counts increased rapidly and reached a peak 10 days after infection. Viable organisms could be isolated from lungs even after 28 days of infection, although the number of bacteria decreased gradually thereafter. 2) Leucocytosis began to appear after 5 days and reached a maximum on day 21. The total leucocyte number increased from 5, 125/cmm (normal value) to 31, 480/cmm, and decreased very slowly. 3) At the time of maximum response, the leucocyte population was composed of 62 % small lymphocytes and 29 % polymorphonuclear leucocytes, while the blood of normal mice contained 50 % small lymphocytes and 45 % polymorphonuclear leucocytes. The number of polymorphonuclear leucocytes increased up to day 5, and the elevated level was maintained thereafter, without remarkable change. On the contrary, the number of small lymphocytes reached a peak on day 21. No significant change was observed in other kinds of leucocytes. 4) Although intravenous injection of pertussal vaccine could induce leucocytosis, the recovery was much faster than that of intratracheally infected mice. 5) Increase in spleen weight of mice was observed during the early stage of in f ection, while thymus weight remained unchanged.View full abstractDownload PDF (657K) -
II. IMMUNE RESPONSE INDUCED BY INTRATRACHEAL INFECTION IN MICESadatoshi TABAYASHI1981 Volume 41 Issue 4 Pages 445-449
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSBoth local and systemic immune responses were demonstrated in mice intratracheally infected with B. pertussis. Passive protection was assayed by the ability of bronchial washings and sera to protect mice from lethal intracerebral infection. Active immunity in intratracheally inoculated mice was directly assayed by the intracerebral challenge.
1) Passive protection was observed in bronchial washings collected 2 or 3 weeks after the intratracheal infection, suggesting the temporal appearence of local immunity. On the other hand, the protective activity of sera was maintained for a longer period of time.
2) Active immunity against intracerebral challenge became detectable 2 or 3 weeks after the intratracheal infection, and very strong protection was demonstrated at 4 and 5 weeks.
3) By the passive cutaneous anaphylaxis reaction, the formation of an IgE-like antibody, specific for B. pertussis, was detected in sera of mice, past the range of 5-10 weeks after infection.View full abstractDownload PDF (621K) -
Fumio MATSUMOTO1981 Volume 41 Issue 4 Pages 451-458
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn this study, the mechanism of [3H] Leu-enkephalin uptake into synaptic vesicle fraction from bovine caudate nucleus was investigated. The simultaneous addition of 2 mM MgCl2, 2 mM CaCl2 and 2 mM ATP stimulated the uptake 22 times over the control value; whereas, the separate addition of these agents augmented the uptake 2.4 times, at most. The addition of 2 mM MgCl2 plus 2 mM ATP and of 2 mM CaCl2 plus 2 mM ATP increased the uptake 6.6 times and 4.5 times, respectively. The cation, ATP-dependent uptake reached its half-maximal level within 10 min, after the initiation of incubation at 25°C, and a small degree of Leu-enkephalin was taken up at 0°C. The apparent Km value for the uptake of [3H] Leu-enkephalin was 1.8×10-7M. Guanosine triphosphate stimulated uptake as well as ATP ; whereas, CTPand ITP were only one quarter as effective as ATP. The cation, ATP-dependent uptake was inhibited by 35%, 25% and 20% in the presence of 0.1 mM ouabain, 0.1 mM Cholchicine and 1 mM reserpine, respectively.View full abstractDownload PDF (2320K) -
Toshihiro TAKABA, Norio INOU, Makoto FUNAMI, Hiroshi MAEDA, Mototoshi ...1981 Volume 41 Issue 4 Pages 459-463
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSurgical treatment of lung cancer at Showa University Hospital is reported in this study.
From 1975 to 1980, 56 cases of lung carcinoma were treated surgically at Showa University Hospital. Among these patients, there were 31 epidermoid carcinomas, 23 adenocarcinomas, one small cell carcinoma and one large cell carcinoma.
According to the clinical staging of the Japan Lung Cancer Society, there were 4 cases in stage I, 10 cases in stage II, 30 cases in satge III and 12 cases in stage IV, and 31 cases had complete, potentially curative resection of their primary tumor.
Of 32 patients with an estimated 3 year survival rate, a 3 year 75 % survival rate of the patients undergoing curative resection was predicted. However, 17 patients died during one postoperative year, 6 cases died in immediate postoperative period, due to cardio-pulmonary complications.View full abstractDownload PDF (596K) -
Seiichiro TAKAHASHI, Makoto ARAI, Keiichiro YONEYAMA, Kazuaki YOSHIDA, ...1981 Volume 41 Issue 4 Pages 465-468
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS10 cases of chronic pancreatitis were diagnosed by ultrasonography. No pancreatic abnormality was found in 6 cases, which had been diagnosed as chronic pancreatitis by ERP, by ultrasonography. It was possible to diagnose 3 cases of pancreatic carcinoma using ultrasonography, showing low echo level tumors.
Liver tumors were classified into two types, according to echo level; high echo level and low echo level types. It might be difficult to differentiate hepatoma and metastatic tumors only by echo pattern. It was concluded that ultrasonography was useful as a screening test of chronic pancreatitis, pancreatic cancer and liver tumors, due to its simplicity and noninvasiveness.View full abstractDownload PDF (3862K) -
—A COMPARATIVE EVALUATION OF CT AND SCINTIGRAPHY—Kenji TAKIZAWA, Yoshisada HIRONO, Takehiko GOKAN, Shinich ITO, Takashi ...1981 Volume 41 Issue 4 Pages 469-474
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn 77 cases with liver disease which were diagnosed after several examinations, computed tomography (CT) and radionuclide scintigraphy (RNS) were evaluated.
Tumorous lesions were found in about 70 % of all cases by RNS : 12 primary liver cancers, 21 metastic liver cancers and 15 liver cysts. Their detectability by CT (95 %) was supeior to that by RNS (70 %) .
In scintigraphy, some cases with small sized lesions tended to be misinterpreted as diffuse inhomogeneous images, and circumferential lesions were often misinterpreted as liver deformities.
In CT, the difference between primary liver cancer and metastic liver cancer could not be detected in some cases, and some diffusely invaded cancerous lesions were overlooked.
Liver cystic lesions could be seen as well circumscribed low density areas. CT was a very useful tool for detection of liver cysts.
In the cases of diffuse liver diseases, 20 liver cirrhosis and 9 hepatitis, CT did not reveal superior information to that by scintigraphy.
The combination of these two methods brought about higher detectability of liver lesions, and therefore, is very effective as a means of diagnosis.View full abstractDownload PDF (6536K) -
Hiroyuki TAZAKI, Tadashi WATANABE, Mitsuo KINEBUCHI, Tetsuji SHIMADA, ...1981 Volume 41 Issue 4 Pages 475-480
Published: August 28, 1981
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe rate of early gastric carcinoma in young adults under 30 years of age was apparently limited. In this paper, 2 cases of early gastric carcinoma in young adults, one is 23 year old unmarried female and another 22 year old unmarried female, are reported with a review of the literature. The incidence of early gastric carcinoma in the young was 2 cases (2.9 %) among 68 in which cancerous invasion was limited to submucosal layer, detected by gastric resection in our hospital from Oct., 1975 through April, 1981.
Epigastric pain was present as an early symptom in these cases. The duration of these symptoms was longer than approximately 3 to 5 years before surgical procedure. Macroscopic classification of these cancer lesions showed depressed types (IIc) . Protruded type (I, II a) of early gastric carcinoma, was very rarely reported in published studies on cancer in the young. Microscopic appearance of cancers showed signet-ring cell carcinoma (sig.) in one, and poorly differentiated adenocarcinoma (por.) in another, having ul-II ulcer in the center of depressed cancerous invasion. The degree of cancerous invasion was, one in the submucosal layer and another case in the mucosal layer, and an absence of metastases was found.
These two cases were convalescing satisfactorily. Consequently, we found that early detection of cancerous lesions and early surgical procedure provides satisfactory results in the treatment of the young, as well as in treatment of older sbujects.View full abstractDownload PDF (6513K)
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