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Volume 42, Issue 1
Displaying 1-12 of 12 articles from this issue
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Setsuro KURIYAMA, Kiyotaka NAKAJIMA, Kazuhisa OHMURA, Keiichi HUKUZAWA ...1982 Volume 42 Issue 1 Pages 5-12
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS23, 979 patients have been examined in our clinic from 1975 to 1979; among them, 1, 055 patients (4.4%) or 1, 111 cases were sports-related injuries and disorders. These cases were classified according to : 1) Sex, male 68.9%, female 31.1%. 2) Age, twenties 43.3 %, latter half of teens 20.6 %, thirties 13.1 %, early half of teens 11.3 %. 3) Type of trauma, fracture 28.7 %, sprain 24.0 %, contusion 9.8 %, low back pain 6.9 %. 4) Region affected, knee 13.2%, finger 12.9%, ankle 11.8%, shoulder 10.9% and back 10.2%. 5) The sports events and frequent injuries were that : skiing 17.0% (lower leg fracture 21.2%, knee sprain 16.8%, ankle sprain 12.3 %), baseball 13.4% (fracture, sprain and dislocation of the finger 23.0%, ankle sprain 5.5 %), football 13.4% (fracture and sprain of the ankle 21.3%), ruggby football 4.5%, volley-ball 7.0%, basket-ball 6.2%, judo 4.1% (dislocation of the acromio-clavicular joint 27.9%), golf 3.4% (low back pain 27.8%), tennis 2.8% (knee sprain 30.0%, tennis elbow 20.0%) Each sports event has features and frequency, regions and types of trauma related to itself. And it is very useful to know these tendencies in diagnosis and treatment of sport-related injuries and disorders.View full abstractDownload PDF (752K) -
Fusaji KUMURA, Mikiko KANDA1982 Volume 42 Issue 1 Pages 13-21
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the present study, sodium dipropylacetate (DPA) was administered in order, to prouduce pancreatic disorders and, through this experiment, pathomorphological analyses were performed in order to clarify some of the factors involved in causing acute pancreatitis. Young male guinea pigs were used as masterials, and 50-300 mg of DPA/-100 grams of weight were injected into the abdmital cavity from once to 21 times a day (four different dosages, seven groups) . In Groups 1-3, the resultant changes were in direct proportion to the number of injections and the concentration of the agent both in the number of changes and their respective degrees. These changes included slight changes of the acinar cells, changes of the ultraorganelles within the protoplasm and the appearance of vacuoles (swelling of the mitochondria and inner cavity dilation of the rough endoplasmic reticulum and its formation of large vacuoles) . In Groups 4 and 5, a large number of the aforementioned vacuoles were found to be at verying stages of development and, when advanced, clasmatosis of the cells was present. In Groups 6 and 7, the aforementioned vacuoles at stages ranging from initial to intermediate were found, although the degree of the changes varied. This indicates that the higher the concentration level and the greater the number of injections, the greater the number and degree of the changes. As mentioned above, the effects DPA has on the pancreas involve direct disturbance of the acinar cells, which are the parenchyma of the pancreas, and the discrepancy between these findings and references in the literature to pancreatitis in humans must be clarified in future studies. The kind of pancreatic disorder caused by injection of DPA is believed to be the degenerative type among the acute pancreatic disorders-acute parenchymatous pancreatitis-in the classification of pancreatic disorders suggested by the authors.View full abstractDownload PDF (5982K) -
Toshihide KAZAMA, Yoko TANAKA, Yoshio ISHIBASHI, Toshiyuki SUETSUGU, T ...1982 Volume 42 Issue 1 Pages 23-33
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDirect immunofluorescent test were performed on 409 cases (496 specimens) of various skin diseases, including 137 cases of collagen diseases, 45 of cutaneons vasculitis and purpura, 31 of bullous disease and 196 of the various other skin diseases. Immunopatho-logical findings of the vasculitis group, bullous disease, SLE and DLE and lichen planus, demonstrated similar results to those in our previous reports. In the cases studied in the past five years, we experienced a case with widespread-DLE whose skin specimen obtained from the back (without eruptions) had showed positive LBT progressed to SLE later. Moreover, in the cases which were previously diagnosed as dermatomyositis and showed positive LBT, the disease was later diagnosed as overlapping syndrome or a transitional phase to SLE. Furthermore, IgG and C3 deposits in the skin tissue are detectable in several cases of the other skin diseases, which are not believed to be mediated by immune mechanisms. Thus, these results suggest that immune mechanisms may involve the pathogenesis of the many various skin diseases. It is also stressed that immunopatholgical tests may become convincing tools for dermatological diagnosis.View full abstractDownload PDF (1026K) -
SIMULTANEOUS DETERMINATION OF CHLORPROMAZINE AND LEVOMEPROMAZINE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY USING ELECTROCHEMICAL DETECTIONTadataka UENO1982 Volume 42 Issue 1 Pages 35-43
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA rapid, selective and sensitive method for the simultaneous determination of chlorpromazine (CPZ) and levopromazine (LPZ) in human plasma has been developed using high-performance liquid chromatography with electrochemical detectors. The unchanged drugs and internal standard extracted from plasma were separated by reversed-phase, high-performance liquid chromatography and separation was completed within 10 min. The influences of acetonitrile concentration and those of pH of the mobile phase were investigated. The minimun detectable amounts were 100 pg for CPZ and LPZ, respectively. In comparison with other three detection systems, this one was found to be the most sensitive. This method was applied to the simultaneous determination of CPZ and LPZ in human plasma.View full abstractDownload PDF (880K) -
Hirobumi RYU1982 Volume 42 Issue 1 Pages 45-56
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe mechanism of multiple granule extrusion and the fate of granule membrane retrieved from the cell surface after exocytosis were studied using horseradish peroxiase (HRP) as a histochemical trace, and also the localization and distribution of acid phospatase (AcPase) activity was observed in the pituitary thyrotrophs of rats 10, 30 and 60 min after intravenenous injection of 200 μg of thyrotropin releasing hormone (TRH) . In the thyrotrophs 10, 30 and 60 min after injection of TRH, single or multiple granule extrusions by exocytosis and coated pits on the cell membranes, as well as on the surfaces of large invaginations of multiple granule extrusions, were often found. HRP molecules were taken up into the coated pits and smooth-surfaced vesicles in the cytoplasm. Thirty min after TRH injection, uptake of HRP molecules was recognized within the large invaginations of the cell membranes with cores of secretory granules following multiple granule extrusion, and HRP molecules were also found in the large vacuoles with many cores of secretory granules in the cytoplasm of thyrotrophs. Thirty and 60 min after TRH injection, small vesicles with HRP increased around the Golgi apparatus and a small number of HRP molecules were occasionally recognized within the trans-side of Golgi cisternae. AcPase activity was found within the Golgi vesicles and the trans-side cisternae of enlarged Golgi apparatus in the thyrotrophs 30 min after TRH injection. Primary lysosomes were sometimes fused with the phagosomes consisted of retrieved vesicles. From these findings, it may by considered that multiple granule extrusion occurs as a series of successive exocytosis of secretory granules, i. e. first one secretory granule is fused with the cell membrane and then opened into the extracellular space, subsequently another granule fuses to the base of the first extrusion granule and so on in similar fashion until a multiple granule extrusion is finally formed. These results also suggest that most of the granule membranes retrieved by endocytosis are digested by lysosome and some of them move to the Golgi apparatus and fuse with the trans-side cisternae.View full abstractDownload PDF (16657K) -
Takashi IGUCHI, Yukiko NAKAGAWA, Hitoshi ITABASHI, Hiroshi HOTTA, Haji ...1982 Volume 42 Issue 1 Pages 57-72
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis study reviews the cases of 501 in- and out-patients treated at Karasuyama Mental Hospital, affiliated with Showa University since 1979. The patient's current status and emphasis of treatment for schizophrenia and related disorders is reviewed. Also, indices related to psychotic recuperation rates are analyzed. 1) Adaptability to society has been divided into 6 stages on the basis of socialization, along with the general assessment on schizophrenia. Namely, a division was made on comparison of groups of “favorable”, “intermediate” and “unfavorable” recuperation. The favorable recuperation group was 13.6%, the intermediate group was 58.7% and the unfavorable was 27.6%. The intermediate group, with the sub-classification of middle-stable and unstable was determined from the average picture of the chronic psychotic state indicated by the results of psychiatric treatment of schizophrenics. This group was divided almost equally between in- and outpatient, implying that administered treatment on this group becomes an important subject in psychiatric rehabilitation. 3) It is not certain whether change in the therapeutic method influenced the recuperation rate of schizophrenics, but the effect can be seen in the increase in the intermediate group. The effect also brings out the decrease in catatonictypes and increase in hebephrenics. 4) On factors related to prognosis of typical groups of schizophrenics, no significent relationship was recognized either way. Hereditary predisposition was 4`x.9 % of the total, but this and prognosis are largely irrelevant to one another. Among the hereditarilly predisposed group, dominance complexes accounted for 22.8%, inferiority complexes, 70.6% and intermediate dillusions, 6.6%. However, between dominance and inferiority, there was no significant difference in final prognosis.View full abstractDownload PDF (2062K) -
Shigeru TOMOYASU, Hiroshi HASEGAWA1982 Volume 42 Issue 1 Pages 73-80
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe purpose of the present study is the elucidation of the pathophysiological signifigance of ceruloplasmin in various diseased states. The correlation between serum ceruloplasmin levels and some hematological values was investigated. Immunoelectrophoretic study was carried out with rabbit antibodies to human ceruloplasmin for detecting apoceruloplasmin in the sera of aplastic anemia, liver cirrhosis and other diseases. Results were as follows: 1) A positive correlation was found between serum ceruloplasmin levels and serum copper concentrations in all diseases except chronic hepatitis and renal failure cases undergoing hemodialysis treatment. 2) In aplastic anemia, serum ceruloplasmin correlated negatively with hemoglobin concentration, red blood cell counts and hemotocrits. There was a positive correlation between serum ceruloplasmin levels and serum iron concentrations. In iron deficiency anemia and acute leukemia, there was a negative correlation between serum ceruloplasmin levels and hematological values, except for serum iron concentration. 3) Im-munoelectrophoresis of normal human sera did not reveal an apoceruloplasmin precipitin band. 4) Apoceruloplasmin was detected in serious cases of aplastic anemia with severe anemia, high serum iron levels and high serum ceruloplasmin concentrations. Apoceru-loplasmin was found in serious cases of liver cirrhosis with severe anemia, low iron levels, low copper concentrations and slow plasma-disapperance rate of ICG. Apoceruloplasmin was detected in cases of normal pregnancies ranging from 9 to 40 weeks with high serum copper and ceruloplasmin concentrations.View full abstractDownload PDF (2380K) -
Kimihiro KITAMURA, Tatsuaki NOZU1982 Volume 42 Issue 1 Pages 81-87
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn this study, the oxidized form of plasma ceruloplasmin, which has been know to act as ferroxidase in vivo, was oxidized up to 90% ; small amounts of apoceruloplasmin (10-20%) were contained in normal plasma. At present, estimation of apoceruloplasmin alone is difficult, but the immunological method allows the simultaneous measurement of apocer-uloplasmin and the oxidated-type of ceruloplasmin. The plasma content of oxidized ceruloplasmin is determined by the measurement of paraphenylenediamine oxidase activity ; it is therefore possible to measure the apoceruloplasmin concentration indirectly. In the present study, we measured serum ceruloplasmin by the oxidase activity and the immunological method for 38 control cases, 17 cases of liver cirrhosis, 15 cases of acute hepatitis, 7 cases of chronic hepatitis, 33 cases of iron deficient anemia, 12 cases of aplastic anemia, 13 cases of leukemia, 23 cases of cancer, 13 cases of acute nephritis, 6 cases of chronic nephritis, 4 cases of nephrotic syndrome, 11 cases undergoing blood dialysis treatment and 10 pregnancies. The concentrations of apoceruloplasmin and oxidized ceruloplasmin varied with the type and severity of the disease. Comparison of the values measured with oxidase activity and by the immunological method revealed that, in some cases, the biosynthesis of apoceruloplasmin was suppressed and, in other cases, the binding of apoceruloplasmin to copper was impaired.View full abstractDownload PDF (822K) -
Masashi YATSUZUKA, Takao OKAMATSU, Jun-ichi MIURA, Yoshitaka KIN, Sohe ...1982 Volume 42 Issue 1 Pages 89-94
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA statistical analysis of 139 neonatal patients infants at the Showa University Pediatric Surgical Service is reviewed during the period between January, 1970 and December, 1980. The following cases are included: Midgut Malrotation, 18 cases; Intestinal Atresia, 17 cases; Duodenal Obstruction, 14 cases; Anorectal Anomalies, 14 cases; Perforation of the Gastrointestinal Tract, 14 cases; Hypertrophic Pyloric Stenosis, 11 cases; Esophageal Atresia, 10 cases; Omphalocele, 10 cases; and others. There were 84 male infants and 53 females among whom 37 were low birth weight (below 2500 grams) . 139 neonatal infants recieved surgical intervention and medical treatment during the neonatal period, with a postoperative mortality rate of 18.7 % (26 cases) .View full abstractDownload PDF (497K) -
Naofumi NAKAMURA, Hirotake MASUDA, Kazuhiko SOEJIMA, Husaji KUMURA, Ju ...1982 Volume 42 Issue 1 Pages 95-103
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTwo autopsy cases of rheumatoid arthritis with systemic amyloidosis are reported here. In these two cases, diarrhea and abdominal pain were prominent symptoms, and some gastrointestinal disorders had been clinically suggested. Pathologic anatomical and systemic amyloidosis were observed and there were marked amyloid deposits in the wall of the lamina propria of the small intestine, thyroidea and kidney. Some relevant literature was reviewed and gastrointestinal amyloidosis in rheumatoid arthritis was discussed.View full abstractDownload PDF (5828K) -
Akemi OZAWA, Shigeki TANAKA, Nobuo TANAKA, Kazuaki YOSHIDA, Makoto ONU ...1982 Volume 42 Issue 1 Pages 105-108
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAs the antibiotic therapy progresses, the prevention and treatment of infectious diseases develop further. On the other hand, various side effects have been reported, especially the antibiotic-associated colitis is one of the most important cases for its rapid onset and clinical course. A case of Ampicillin-associated hemorrhagic colitis is reported. The patient was a 65 year-old man who was admitted to our hospital with lower bdaominal cramps and bloody diarrhea. Ampicillin administration, characteristic clinical course and colonofiberscopic findings made us possible to diagnose the case as Ampicillin-associated hemorrhagic colitis. The improvement of the symptoms and the disappearance of the mucosal lesion were observed immediately after the discontinuation of the drug. The patient was discharged on the 14th hospital day. Klebsiella oxytoca was detected from the stool culture in this case. Several cases with Klebsiella oxytoca were reported in Japan but not in other countries.
The hemorrhagic mucosal lesion is localized in the right side of the colon in most cases of antibiotic-associated colitis particularly in that of Ampicillin. However, in this case, the lesion was observed in the whole length of the colon. At present, the cause of pancolitis is not clear. It is assumed that the various host factors should be considered as a cause of the colitis other than factors, such as the direct drug effects on the bowel wall or effects of the altered bowel flora.View full abstractDownload PDF (3748K) -
A Case of Erythema Nodosum Caused by Streptococcal InfectionYoshio ISHIBASHI, Toshihide KAZAMA, Yoko TANAKA, Toshiyuki SUETSUGU, T ...1982 Volume 42 Issue 1 Pages 109-112
Published: February 28, 1982
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA male child, aged 4, developed erythema nodosum following streptococcal infection. Direct immunofluorescent study revealed the deposit of IgG, A and complement within and around the blood vessel wall in the dermal subcutaneous portion. Histopatho-logically, the same blood vessel showed slightly neutrophilic vasculitis. These observations suggest that this case relates to an allergic reaction of arthus type.View full abstractDownload PDF (3716K)
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