年次大会
Online ISSN : 2424-2667
ISSN-L : 2424-2667
最新号
選択された号の論文の528件中1~50を表示しています
  • 中山 昇, 髙藤 圭一郎
    セッションID: C201-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    In this citizen forum, we will assemble a model rocket made of paper and plastic. Furthermore, the assembled rocket is launched on the ground. In addition, I will explain how to fly the bamboo dragonfly and the relationship between the bamboo dragonfly and the Mars exploration helicopter. Based on the above experiences, we hope that participating children will become interested in machines, manufacturing, and aerospace.

  • 佐々木 直栄
    セッションID: C204-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    At the last year’s public forum "What is the Alternative ☆ Energy Contest?", Professor Hidetoshi Okubo (Professor Emeritus of Tamagawa University) gave a lecture titled "The very first story of New ☆ Energy Contest". It was a valuable opportunity to get the information I wanted. As someone who inherits the history of the Alternative ☆Energy Contest, it goes without saying that it is important to grasp the entire picture from the birth of this contest to the present in as much detail as possible and to pass it on to future generations. In that sense, my immediate task is to collect and analyze information from the 1st to 3rd contests before I encountered this contest. In this paper, I will focus on the keywords of Professor Okubo's lecture paper, "expansion to regional areas", "energy utilization technology work contest" and "non-electrified refrigerator" and propose measures that will contribute to the sustainable management of this Alternative ☆ Energy Contest in the future.

  • 田中 三郎, 宮岡 大, 佐々木 直栄
    セッションID: C204-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The Alternative ☆ Energy Contest is a new contest on "energy utilization" mainly for university and technical college students, which started in 2008 as an event in which the technology and society departments of the JSME cooperate. The mark "☆" in the title of the contest indicates something that goes beyond the preconceived notions of alternative energy, and the essence of this contest that appeals for novel ideas appears there. From 2012, the year after the Fukushima nuclear accident caused by the Great East Japan Earthquake, a stationary event was held at the Nihon University College of Engineering located in Koriyama City, Fukushima Prefecture, as an event to watch over the reconstruction of Fukushima. The 16th meeting (October 21, 2023) is scheduled to be held on the website with the College of Engineering, Nihon University as the operating base. We are grateful for the opportunity to give an overview of this contest at this civic forum in this paper.

  • 宮岡 大, 田中 三郎, 佐々木 直栄
    セッションID: C204-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 平野 徹
    セッションID: F011-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    First, we will introduce the background of this Forum, and then describe the definition of Extended Digital Twins including the uncertainty and complexity of Humans and Society. The factors of uncertainty and complexity in the CPS process are classified into uncertainty related to things and uncertainty related to events. The Extended Digital Twins including network science will be introduced for modeling complex systems and services related to corporate and social activities such as supply chains and service chains. Knowledge acquisition through AI is also discussed.

  • (不確実性を愉しむ心の数理)
    柳澤 秀吉
    セッションID: F011-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The author proposes Emotion Mechanics to formulate human emotions using a mechanical principle. The core idea is that free energy represents the prediction error with uncertainty processed in the brain as an arousal potential, and that its potential and fluctuations induce emotion valence. Decreasing and increasing free energy induce positive and negative emotions, respectively. Hence, minimizing free energy explains action and perception with positive emotions. At the same time, appropriate level of arousal potential (i.e., free energy) forms positive emotions, suggesting that the brain enjoys uncertainty. The author presents a free energy model to explain the optimum arousal potential from the viewpoint of curiosity and interest. Such emotions encourage exploration that provides a process for achieving well-being.

  • 大島 まり
    セッションID: F011-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    A patient-specific simulation has been exapnding its horizon to clinical applications. Particulary in the field of computational hemodynamics, it is an effective way to grasp blood flow condtions for an indivudal patient. Further advancement of the patient-specific simlauiton can be acheived by predinction of the blood flow after the srugery. The meical data used for the pateinet-specifc simulation contain uncertainties, which affect the simulation results by propagating through mathematical models and the simulation. Thus, quantifying an impact of uncertainties in medical images on simulated quantities is an essential task to obtain reliable results. Since uncertainty quantification requires a large number of case studies to investigate the effects of uncertainties in a probabilistic manner, a surrogate model was developed using a machine-learning techque with data driven by the blood flow simulation. In the session, uncertainty quqntification is presented by the risk predcition of cerebral hyperperfusion syndrome (CHS) with exmples of acutal patient cases.

  • - 何が重要か,どこから手をつけるか-
    藤井 孝藏, 松尾 裕一
    セッションID: F011-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Role of digital twin in manufacturing and how to promote digital twin activities are discussed based on the authors’ three-years’ experience. Some of the suggestions are presented (with the examples in the in-face presentations). We tend to focus on the product digital twin, but production digital twin may be more effective, and easy to apply the concept of digital twin. “Think globally but start small applications without delay” may be the keyword to the digital twin activities.

  • 梅田 靖
    セッションID: F011-5
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 高村 公平, 浅倉 悠斗, 岩下 誠也, 井上 敦貴, 久米村 百子
    セッションID: F021-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Mechanical properties of cells relate to their growth, such as differentiation and cell mortality, and represent the diseases. Investigating the mechanics of cells will contribute to the diagnosis and the study of regenerative medicine. Multiple properties of cells should provide more broad and precise information to us. We evaluated cell mechanics and gene expression analysis using MEMS tweezers, which can characterize and manipulate single suspended cells. To characterize adherent cells, we developed MEMS with a single probe and validated the device. Call trapping and manipulation of the measured adherent cells were also examined using MEMS tweezers.

  • 政池 彩雅, 木戸秋 悟
    セッションID: F021-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Cell adhesion control is a crucial challenge in the design of biomaterials to achieve specific cellular functions and applications. For instance, when implanting artificial organs into the human body, suppressing undesirable cell adhesion becomes essential to avoid adverse biological responses such as blood coagulation and thrombosis. On the other hand, for tissue reconstruction using cell scaffolding materials, ensuring appropriate cell adhesion to the material surface is required. Particularly, cell adhesion morphology is closely associated with cellular processes, including proliferation, differentiation, and orderly structural formation, making versatile control of cell adhesion indispensable in tissue engineering. Cell-substrate adhesion progresses through the binding of cell surface proteins, known as integrins, to adhesion ligands on the material surface. Therefore, the degree of cell adhesion can be manipulated by modulating the presentation of adhesion ligand quantity and its spatial density on the material surface. Traditional material design has focused on modifying adhesion ligand chemistry and physical adsorption characteristics. Additionally, numerous reports have highlighted the significance of material surface mechanics as essential variables in cell adhesion control. As cells exert traction forces on the adhesive substrate, the deformable substrate causes simultaneous movement of integrin-ligand pairs. Consequently, the deformation characteristics of the adhesion interface significantly influence the spatial distribution of adhesion ligands and the binding stability to integrins, representing vital design elements.

  • 亀井 謙一郎
    セッションID: F021-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    My ultimate research goal is to re-create living systems, like human and animals, in vitro. I named this new research field, “Reverse Bioengineering”. To open up this field, we focus on pluripotent stem cells (PSCs) and micro/nanoengineering. PSCs are promising tools, because of their capability for elucidating the fundamentals of the developmental processes of living organisms, but it remains challenging to obtain fully functional tissues/organs from PSCs due to improper cellular environments. In contrast, micro/nanoengineering approach allows to create proper cellular microenvironments for organ development, which conventional macro-scale techniques could not provide. Therefore, the integration of stem cell biology and micro/nanoengineering allows us to recapitulate and understand organ developmental processes within a microchip. Moreover, microfluidic technology provides an artificial blood circulatory system to inter-connect multiple organs, and investigate how they communicate each other, namely “Body on a Chip (BoC).” This BoC is one of the outcomes of Reverse Bioengineering, and I would like to present my works of on-chip development of liver and its diseases as well as early embryogenesis.

  • 宇佐美 初彦, 毛利 拓海
    セッションID: F041-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The present study describes wear behavior of soft thin film coated chromium alloy steel in lubricated rolling/sliding contact condition. Soft thin film consisting of tin (Sn) and zinc (Zn) was coated with dry and wet processes and an additional heat treatment with a halogen lamp was occasionally applied. Wear properties were evaluated with a developed rolling/sliding contact testing apparatus at a constant slip ratio of 20% and at a 3 GPa of maximum contact stress using a ball and a shaft specimen. Results showed that the wear loss of Sn and Zn coating surface fabricated with the dry process was considerably smaller than that of the non-coated and the wet plating specimens. In addition, effectiveness of the heat treatment was found. An x-ray diffraction analysis and a micro hardness measurement are connected to evaluate subsurface mechanical properties and phase transformation. Effects of Sn and Zn coating accompanying with the heat treatment on the wear reduction of alloy steel surface was discussed.

  • 釜道 紀浩
    セッションID: F111-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    A fishing line artificial muscle has attracted attention as soft actuators, which is fabricated by twisting nylon fiber to form coils shape. The actuator is flexible and lightweight, and contracts reversibly with temperature change. By using conductive nylon fiber, it can be driven by Joule heating. In this presentation, brief overview of the fishing line artificial muscle, its control system design and applications are introduced.

  • 難波江 裕之
    セッションID: F111-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 山口 大介
    セッションID: F111-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Pneumatic artificial muscle made of polyimide films will be presented. This artificial muscle is made by welding two 25 μm thick PI films together using a welding technique that is free of pretreatment, additives, and adhesives. The artificial muscle is made entirely of PI, which has high heat resistance, high chemical resistance, and high radiation resistance, and is expected to be used in extreme environments. The artificial muscle generated a force approximately 3,600 times greater than its own weight under natural length displacement constraints.

  • 齋藤 直樹
    セッションID: F111-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • ーその機構学的意味と可能性ー
    森脇 一郎
    セッションID: F113-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 辻本 勝弘, 永田 英理, 中原 好友
    セッションID: F113-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    In recent years, hybrid and electric vehicles have gained attention due to increased environmental consciousness. This trend towards electrification has resulted in a demand for actuators in automotive products that are compact, lightweight, and energy-efficient. To meet these needs, combining a small, high-speed motor with a high gear reduction ratio and efficient power transmission through a reduction mechanism is considered effective. Among them, "face gears" are widely used in the reduction section of actuators that require relatively high gear reduction. Face gears allow for high gear reduction ratio, compactness, and excellent positioning accuracy, making them user-friendly. However, their meshing contact is dominated by sliding friction, resulting in decreased transmission efficiency due to frictional losses. This characteristic hinders the low-power operation of actuators. Therefore, development efforts have been made to replace worm gears with orthogonally meshed gear mechanisms, such as face gears, which have high transmission efficiency when combined with the number of teeth gears. However, addressing design and manufacturing challenges is necessary for practical implementation. This paper reports on the relationship between design parameters and efficiency on the design front, as well as the development status of form rolling techniques for small gears and the manufacturing process of face gears.

  • -釣用リールへの展開と今後の方針-
    井上 徹夫
    セッションID: F113-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Fishing reels are required to have functions such as design, drag performance, and cast feeling, and there is a particularly high demand for gear feeling (fishing reel sensation). It is said that the ultimate angler can read the difference in water quality of the day and the behavior of fish approaching the lure by the feeling of reeling from the handle. To meet this demand, reels are required to have a smooth fishing reel sensation. However, when the reel handle is rotated, vibration occurs due to the meshing of the gear pair, and if the vibration is large, smooth fishing reel sensation is hindered. The precision required by anglers is at the micrometer level, and ordinary processing machines and measuring machines cannot achieve and measure the required precision. This report describes the background and process that were developed with the aim of improving the fishing reel sensation, i.e., "Method of 3D tooth flank modification for the face gear'', "Method of precision measurement for the face gear'' and "Method of precision cold forging for the face gear".

  • -自由な歯車でオンリーワンのモノづくりを-
    前田 憲次
    セッションID: F113-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 泉井 一浩
    セッションID: F121-1
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Design Optimization is one of the research fields that have made significant progress over the past 10 to 20 years. The number of research reports at conferences has increased year by year, and optimization software is being commercialized in various fields. The design optimization methodologies that have been developed in this way are often systematized in terms of optimization algorithms. In practice, however, it is not easy to immediately apply the optimization to practical works even if one has mastered many optimization algorithms. Because of the variety and complexity of problems in the practical design field, model construction and problem formulation processes and post-optimization analysis is quite important in design optimization. This paper discusses what future developments are needed to effectively utilize design optimization methods.

  • 野間口 大
    セッションID: F121-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Model-based development (MBD), or also known as model-based design is the systems design approach where a simulation is a key component. MBD is becoming a promising approach for designing complicated engineering systems, such as automobiles, aircraft, and mechatronic systems with embedded software. However, the definition of MBD is ambiguous since the design and development process is always conducted with any model. Different engineers use this term in different ways. The discussion on MBD is often inconsistent and seems to be an obstacle to its utilization. This paper clarifies the definition of MBD and the situation of its utilization based on the literature survey. Based on the understanding that the purpose of MBD is to share knowledge among engineers involved in system development through system models, this paper discusses the possibility of a knowledge management framework to enhance the effectiveness of MBD.

  • 下村 芳樹
    セッションID: F121-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The real cause of the social problem lies in the misunderstanding and excesses of existentialism and pragmatism. This problematic structure is even more pronounced and serious in Japan, and is the real reason why Japan has rapidly weakened over the past few decades, and is now unable to define itself, only surrendering to other defined platforms. This talk presents the meaning of Platonic Design and an attempt to put it into practice, in which we discover the norms ourselves and, in light of them, create the ideal evolution of correct artefacts and the people for whom they are intended.

  • 田部 洋祐, 井上 哲, 舟根 司, 木村 寿利, 伊藤 真, 渡辺 康一
    セッションID: F181-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    We examined a complex modal analysis of generally viscous and visco-elastic damped vibratory system, which include viscous damping proportional to the velocity of the masses and viscoelastic damping proportional to the force of the linear springs. In this paper, we propose to express the symmetrical state-space equations of the target system in Co-Hamiltonian form to apply the complex modal analysis. We performed numerical simulations for a 3 DOF (Degree of Freedom) system with viscoelastic damping and showed that the state-space equations can be decoupled by the proposed method. We also confirmed that the inverse identification of the forces proposed by the authors for generally viscous damped vibratory system reconstructed the multiple different excitation forces with reasonable accuracy.

  • 西留 千晶, 角田 鎮男
    セッションID: F181-3
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり
  • 高田 博
    セッションID: F181-4
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The Model Based Development (MBD) is the adoption of digital technology to transform real machinery to virtual machinery. MBD of Autonomous Transportation and Logistics machinery is investigated.

  • 中村 英夫
    セッションID: F182-2
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Among the transportation systems, railways are said to be highly safe systems. However, level crossing accidents, which account for one-third of the total, cannot be overlooked due to their social impact. In addition, level crossing has many problems in the transportation economy, such as the problem of level crossings that do not open in urban areas. In this paper, I will examine solutions to these issues from the perspective of "integration of machines and communications". The proposed solution is to control the ground equipment and the train by exchanging information using communication, and will shift from the conventional method of notifying the crew in case of danger to the system in which the train passes through a level crossing when safety is confirmed. Part of this method has already been put into practical use as a function of the wireless train control system (CBTC), and it has been recognized that it is also effective in controlling the fixed time of level crossing warnings. Optimizing the level crossing warning time is also effective in reducing the number of level crossings that do not open, which is a problem at level crossing in urban areas, and can be expected to contribute to the SDGs by reducing ovule gas emissions by realizing smooth traffic flow.

  • 寺田 敦彦, トエ トエ アウン, 永石 隆二
    セッションID: J011-01
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Under the long-term storge of wet radioactive waste materials, hydrogen(H2) is generated by radiolysis of water, and the reduction of the risk of explosion and combustion plays an important role. Since water vapor condenses on the walls of storage vessel, the behavior of H2 is mainly in H2-air-steam (water vapor) atmosphere inside of storage vessel. Therefore, it is important to understand the condensation process of water vapor accurately and grasp the change of H2 concentration. In this study, CFD simulation method for estimating the amount of condensation of water vapor based on the heat-mass transfer analogy was used when the introduced gas was set to helium (He). An evaluation based on the comparison between the analytical results and the experimental values was carried out. As a result, it was found that the reproducibility of the experimental results was improved by using the condensation model considering the simple liquid film behavior.

  • 月川 久義
    セッションID: J011-02
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    This paper describes about CFD results of the Hallway model, changed leak size 35mm×35mm instead of 150mm ×300mm.Hydrogen concentration at sensor 1 and sensor 4 decreased to 0.25%, and disappeared hydrogen concentration fluctuation. These results show too large hydrogen leak size generate ambient air reveers flow into hydrogen leak and makes hydrogen flow fluctuation.

  • 錦 慎之助
    セッションID: J011-03
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Japan has declared its goal to become carbon neutral by 2050, and various efforts are underway. Utilization of hydrogen is one of the leading candidates for decarbonization. In order to use hydrogen safely, it is necessary to quickly detect leaked hydrogen, and it is considered essential to build technology and accumulate know-how to predict hydrogen concentration with high accuracy. Inoue et al. carried out hydrogen leakage and dispersion experiments using the Hallway Model, and author et al. showed that numerical simulations can accurately reproduce them. In this paper, in order to investigate the effects of obstacles placed in the Hallway Model on the hydrogen concentration distribution, numerical simulations are performed using a Fire Dynamic Simulator (FDS) under various conditions. In cases of hanging walls, the hydrogen concentration increases locally, but there is no significant change in the entire Hallway model. In cases obstacles which is placed near the floor, the turbulent flow in the Hallway model was suppressed depending on the placement location, and then hydrogen concentration increases in the upper part of the Hallway model.

  • 松浦 一雄, 松本 スラビンク ありさ, 菅 貴文
    セッションID: J011-04
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Hydrogen is expected to leak in a variety of situations, from production to consumption. In order to realize a hydrogen sensing system that is more flexible and quicker than conventional systems, we have proposed a new drone-based system for hydrogen sensing with a small thermal conductivity type hydrogen sensor. Initially, quad-rotor drones were thought to be unsuitable for hydrogen leak detection because hydrogen is pushed away from the drone by propeller downwash. However, recent CFD (Computational Fluid Dynamics) analysis and smoke experiments have shown that hydrogen leak detection is possible even under the propeller downwash. It became clear that the actual hydrogen was also pushed down by the descending airflow once, and then passed outside on the circulating airflow to reach the drone. In order to study the path of hydrogen transport around the drone, we propose a simple model of a stochastic partial differential equation on the basis of potential flows and random disturbance.

  • 森岡 誠, 嶌田 圭祐, 桃井 優一, 加藤 喜峰
    セッションID: J011-05
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    It is important to study hydrogen flow in a pipe for safety in the hydrogen society. In this study, the ultrasonic method was used to observe the helium replacement of the nitrogen-filled bent pipe, and the reliable replacement method was investigated. It is found that nitrogen in the pipe near the exit is never replaced with helium 100 % due to the difference in specific weights of nitrogen (or air) and helium. If the exit shape is changed so that the air does not flow backward into a pipe, it is found that it is possible to replace the air with helium 100 %. The ultrasonic gas concentration measurement method does not require drilling holes in the pipe for measurement and is a safe method that can measure concentrations without direct contact with the gas. Helium was used instead of hydrogen for safety reasons. Previous studies confirmed that there is almost no difference in gas replacement behavior even when helium is used as a substitute gas for hydrogen.

  • 阿久津 元秀, 下田 泰聖, 島田 航太朗, 佐藤 哲也
    セッションID: J011p-02
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Cryogenic fluids, such as liquid hydrogen and liquid oxygen are used as propellants. However, these liquids have quite low boiling temperatures and easily become a gas-liquid two-phase flow in pipes leading to difficulties in controlling the flow rate and causing problems. Therefore, we have tried to develop a two-phase flow meter using a capacitive void fraction sensor and deep learning techniques (BLSTM). To realize an accurate regression model, we have selected 9 features (from 19 features) including 3-scale wavelet package transform (8 features) and moving range of capacitance with the sliding window method In line with previous research, and we have achieved a more accurate model than raw signal input model by 0.15 (RMSE). In addition, to realize a reliable regression model, we have applied XAI techniques (PFI, PD, ICE). We have found that one approximation signal from wavelet transform and moving range are important for the regression model, and the liquid flow rate increase exponentially to the signal and linearly to the moving range.

  • Zi Wang, Naofumi Ohtsu, Hanif Saifurrahman, Makoto Ohta
    セッションID: J021-01
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Stent is currently widely used to treat cardiovascular diseases, such as stenosis and aneurysm. Endothelial cells (EC), the components of vascular endothelium, denudation during stent implementation leave the risk of severe complication known as restenosis. Restenosis could re-block the vessel lumen lead to the failure of stenting treatment. To prevent restenosis, surface treatment to enhance the stent surface biocompatibility has been made to accelerate the process of EC migration onto to the stent, known as stent endothelialization. Anodization on nitinol is a simple and efficient approach to improve biocompatibility of nitinol stent surface by enhancing the surface hydrophilicity, thus increasing the EC activities. Researchers found that EC activities could be affected by the blood flow. The implanted stent structure could disturb the flow environment near the EC layer cause the EC dysfunctions, then leading to restenosis. Therefore, it is important to study the EC activities on the nitinol stent surface with anodization treatment under the flow conditions. To realize that this research performed the flow exposure experiment for 24 hours. A parallel plate flow chamber was designed to generate constant wall shear stress (WSS) to the EC monolayer. Nitinol stent strut with anodization was placed within the flow chamber. EC attachment and morphology on the surface of stent strut were then observed. The static experimental conditions were chosen as the control. The result found that EC density on the surface of anodized stent strut was higher than the non-treated stent under both with and without flow conditions. EC density under the static conditions was higher than the flow conditions. Comparing with the static conditions, EC morphology was found as long and thin in the response to the flow stimuli. Anodization could enhance the EC migration onto the nitinol stent strut surface by improving the surface hydrophilicity. Therefore, the anodization surface treatment method might accelerate the stent endothelialization process. The improvement of surface hydrophilicity may could be reduced under the flow conditions.

  • 細井 健司, 清水 正樹, 網塚 貴介
    セッションID: J021-03
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    High frequency oscillatory (HFO) is an artificial ventilation method that allows adequate gas exchange by supplying an oscillating flow with a high ventilation rate of 5 to 30Hz through the tracheal tube into the airway at a single tidal volume (TVHFO:2~3ml/Kg) smaller than the dead space capacity. The authors have developed a small-sized generator for Nasal-CPAP (HNCPAP) using an air-curtain and entrainment that can control MAP (Mean Airway Pressure) and HFO separately. This paper describes Nasal-HFO characteristics of HNCPAP. Experiments were conducted using the simulating healthy lungs breathing mode of a spontaneous breathing simulator for neonates, with constant MAP, and with and without HFO at three tidal volumes (TV), respectively. In the experiment, the following parameters are measured: alveolar pressure (Palv) just before the test lung, airway pressure (Paw) after passing HNCPAP, CPAP pressure (Cpap), and sub pressure (Sub) and inhalation and exhalation flow (Flow). The experimental conditions are MAP500Pa, respiratory rate 50breaths/min, HFO frequency 15Hz, stroke volume 15ml, tidal volume 2ml, 5ml, and 7ml. The following results were obtained. (1)ΔPawHFO on inhalation increased in dependence on TV and reached the alveoli without halving in the airway. (2) The entrainment effect was significantly halved when HFO was added in the first half of exhalation, and (3) TVHFO on inhalation increased in a TV-dependently and was about half that of HFO in the case of tracheal tube. Finally, we were able to clarify the Nasal-HFO characteristics and fluid device properties when HFO was added to HNCPAP.

  • 佐藤 秀平, 池谷 直紀, 田中 学, 太田 信, 山口 隆平, 中田 敏是
    セッションID: J021p-01
    発行日: 2023年
    公開日: 2024/03/25
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    The purpose of this study is to experimentally investigate the effect of wall deformation on flow behavior using a cerebral aneurysm model that considers patient-specific elastic deformation. Therefore, we measured by two-dimensional PIV and compared the time-series change of flow velocity and wall shear stress (WSS) under the condition of deformation of the model and the condition of less-deformation. The model used in this study was fabricated by the dipping method and is made of silicon. Imaging was performed using a high-speed camera and a UV laser. WSS was calculated from the wall-parallel velocity component at a distance of 0.25 mm from the aneurysm wall. As a result, turbulence of the flow velocity between cycles was observed under both less-deformation and deformed conditions, confirming the instability of the flow. In addition, the wall shear stress was smaller under deformation conditions than under less-deformation conditions, suggesting that the elastic deformation of the aneurysm wall reduces the wall shear stress.

  • 飯島 悠太, 前田 修作, 大谷 智仁, 山田 茂樹, 間瀬 光人, 和田 成生
    セッションID: J021p-06
    発行日: 2023年
    公開日: 2024/03/25
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    The brain is a fluid-saturated poroelastic material and keeps its mechanical balance between solid and fluid phases in an intracranial space. Changes in the intracranial water contents due to the loss of neurons with aging lead to brain deformation as cerebral atrophy, while this mechanical implication remains poorly understood. This study aims to develop a computational mechanical model of cerebral atrophy with considering anatomical brain shape and the volume change of brain tissues. The brain was modeled as compressible hyperelastic materials and its volume decrease with aging was modeled as plastic deformation by changing its reference state. The mechanical balance state of the brain with its volume decrease was computed using Galerkin finite element method. Obtained results showed characteristic brain deformations consistent with clinical knowledge. This finding suggests that mechanical balances would be one of the essential factors to understand the mechanism of brain deformation with aging.

  • 牛奥 隆博, 柏原 弘稜, ユ モショ, 吉村 浩明
    セッションID: J022-01
    発行日: 2023年
    公開日: 2024/03/25
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    A cloud of bubbles induced by a high-speed submerged water jet shows a collective unsteady motion repeating a process of growth and collapse. It is considered that a high-pressure shock wave is emitted associated with the collapse of the cloud, and such shock wave phenomena have been used in the applications to medical and environmental fields. However, the elementary process of such unsteady behaviors of the cloud and the shock wave phenomena has not been well understood through experimental observations. In this study, we make experimental observations and measurements of two-dimensional velocity fields around the cloud cavitation that is induced by Ho:YAG laser via the fluorescent Particle Image Velocimetry (PIV) method. In particular, based on our previous numerical tests (2), we illustrate the flows of twin vortices that appear around the cloud and move along its interface. Finally, we experimentally clarify the existence and the motion of the twin vortices in the growth and shrink processes of the cloud, from which it follows that the unsteady behavior of the cloud is synchronized with the motion of the twin vortices.

  • 藤波 虎太朗, 岡庭 純, 貝塚 太一, 白井 克明
    セッションID: J022p-01
    発行日: 2023年
    公開日: 2024/03/25
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    Photoacoustic 3D imaging using pulsed light irradiation has been realized for high-resolution three-dimensional visualization of vascular structures from the biological surface to several centimeters in depth. It is currently restricted to morphological imaging with some exceptions. We focused on velocity measurement based on cross-correlation analysis of photoacoustic signals toward realizing blood flow velocity measurement. We used sinusoidal linear motions of a solid object for evaluating the performance of photoacoustic velocity measurement. The object was irradiated with a pair of laser pulses with a time difference, and the generated photoacoustic signals were acquired. Cross-correlation of a successive pair of photoacoustic signals from an object provides a time shift due to the motion of the object. From the time shift, the object moving velocity can be obtained with known sound speed and the time difference between the successive irradiations of the laser pulses. The object motion was independently measured with a laser displacement sensor simultaneously during the measurement. The result of the photoacoustic velocity measurement performance with a standard deviation of about 5 to 10% was obtained for a pre-setting velocity in range of several 100 mm/s.

  • 岡村 謙, 佐藤 瑶介, 髙田 智史
    セッションID: J022p-02
    発行日: 2023年
    公開日: 2024/03/25
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    The study of stress characteristics in elastic bodies can help explain the deformation and fracture processes of objects. It is used to assess, design, and improve the safety and durability of structures such as bridges and skyscrapers. Often objects have voids in their interior. The actual internal stress distribution differs from the theoretical solutions of solid objects. Therefore, we study the elastic body with a cavity. In this talk, in order to study the behavior and characteristics of the internal stress propagation in an elastic hollow disk, we investigate the stress propagation in a disk with a hole in its interior when a counter concentrated load is applied. In particular, we observe the long time limits of the solutions using the final value theorem of the Laplace transformation, as it plays a crucial role in the description of the material and makes it easy to understand.

  • 小野 泰斗, 中楯 浩康, 張 月琳
    セッションID: J023p-03
    発行日: 2023年
    公開日: 2024/03/25
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    In baseball, frequent ball head collisions are high-speed collisions with low-mass objects, a characteristic concussion injury situation compared to other sports, suggesting that the mechanism and threshold for concussion onset may be different. In this study, we investigated the mechanical response of the brain during ball impact using finite element analysis. The peak values of all mechanical parameters of the brain increased in dependence on the translational velocity of the ball. As the rotational velocity of the ball was increased, the rotational acceleration and the maximum principal strain increased, but the translational acceleration did not change. The increase in peak values when the translational velocity of the ball was changed was greater than the increase in peak values when the rotational velocity of the ball was changed for all the brain mechanical parameters. This is thought to be due to the increase in impact force, suggesting that translational velocity of the ball has a greater effect on the brain dynamic response than rotational velocity of the ball.

  • 磯部 友誠, 本宮 潤一, 田村 篤敬
    セッションID: J023p-04
    発行日: 2023年
    公開日: 2024/03/25
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    Mechanical properties of white and gray matter are essential to accurately predict spinal cord injury (SCI) due to blunt impact. In the present study, we conducted mechanical characterization of the spinal cord using a custom-built microindentation tester and closely investigated the difference between white and gray matter with a distinction of specific anatomical sites, i.e., cervical and lumbar regions as well as dorsal and ventral sides of the spine. Consequently, no significant difference was found between the Young’s moduli of white and gray matter. However, it was found that the Young’s modulus of the cervical region is more compliant than that of the lumbar region (P < 0.01), while the Young’s modulus of the dorsal side is significantly higher than that of the ventral side (P < 0.05). We need more studies to support the findings obtained here, but these results may indicate that the cervical and ventral regions are more susceptible to SCI when a traumatic load is applied to the spine.

  • 佐藤 廉, 八木 一平, 砂川 弘憲, 柿花 隆昭, 加藤 英子, 内田 諭
    セッションID: J023p-06
    発行日: 2023年
    公開日: 2024/03/25
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    Benign esophageal stricture is a condition that narrows the esophageal lumen and causes dysphagia, often following esophageal cancer treatment. The lesion accumulates collagen due to excessive healing of tissue damage called fibrosis. Collagen serves to harden the strength of the tissue, thus making the lesion mechanically stiff. The standard treatment for benign esophageal stricture is balloon dilatation, which mechanically widens the esophagus, leading to repeated lacerations and restenosis during recovery. We proposed a treatment concept in which balloon dilatation is followed by local heating of the lesion to reduce lacerations and subsequent restenosis. We believe that heating decreases lacerations by thermally denaturing collagen to gelatin and decreasing tissue strength. We developed a balloon that can be simultaneously heated and dilated by hot water flowing through its interior. We performed porcine animal experiments with a locally heated balloon in which the heated area was restricted by an insulating membrane. We successfully heated and dilated a locally heated balloon and evaluated the effect of heating on the tissue by staining the lesion with HE and MT. The results provide insight into tissue damage caused by esophageal cancer treatment and tissue damage caused by heating.

  • 上杉 薫, 柏木 悠里, 豊田 太郎, 長山 和亮
    セッションID: J024-01
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    The liposomes have been focused on as the packages of the molecular robots that change their shape by using the actuator molecules such as molecular motors, DNA, RNA, or any other added substance. To achieve the desired change in shape using the small force generated by these actuator molecules, it is crucial to understand the mechanical properties of the liposomes. For evaluating the mechanical properties of the liposomes, we applied a microfluidic device because microfluidic devices can trap and hold multiple liposomes quickly and simultaneously without skilled techniques. The microfluidic device consisted of multiple evaluation areas that connect in series. The evaluation areas were rectangular-shaped funnel channels designed to mimic the shape of the micropipette used in the micropipette aspiration method. The funnel width was approximately 5 μm. When the liposome suspension was introduced into the microchannel, each funnel trapped a single liposome. The membrane tensions of the liposomes were calculated from the deformation of the liposomes. The liposomes were prepared by the water-in-oil (W/O) emulsion method with a composition of POPC : DOPG : Cholesterol = 9 : 1 : 1. We confirmed that 20 funnels could trap liposomes, with a success rate was 45% (in one device). The average membrane tension of three liposomes was 0.40 ± 0.08 mN/m. By estimating the force of molecular actuators required for the formation of the tube structure using derived membrane tension, we demonstrated the effectiveness of the microchannel as a tool for developing molecular robots.

  • 中島 桜太, 齋藤 匠, 松永 大樹, 出口 真次
    セッションID: J024p-01
    発行日: 2023年
    公開日: 2024/03/25
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    Intercellular proteins are continuously exchanged by chemical reactions called turnover. Fluorescence recovery after photobleaching (FRAP) is a technique to evaluate the intercellular molecular dynamics, for exsample, turnover rate and mobile fraction in living cells. The knowledge on the molecular dynamics in entire intracellular regions can help us understand the complicated phenomenon in living cells. However, it is difficult to evaluate it because of the intrinsic limitation of FRAP experiment. Here, we applied spatial statistics to FRAP experiments to estimate the dynamics in entire intracellular regions even with limited numbers of data. Kriging is a method of interpolation of spatial statistics, and it provides a liner unbiased prediction at unsampled locations. Before interpolation using kriging, we check whether there is spatial autocorrelation in the region of interest with Molan’s I. If there is a certain level of spatial aotocorrelation, we can interpalate using kryging. We thus conducted FRAP experiments, checked the spatial autocorrelation, and interpolated with three A7r5 cells transfected with EGFP-Tublin. We found a spatial autocorrelation in the turnover rate and mobilefraction in the entire regions of some cells. Thus, our results suggest that spatial statistics is useful to know molecular dynamics in the entire intracellular region.

  • 礒部 修友, 千葉 大智, 市川 賀康, 伊藤 翔, 西野 達哉, 元祐 昌廣
    セッションID: J024p-02
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Techniques for the analysis and manipulation of biological nanomolecules are highly required. This study investigated the manipulation behavior of the biological nanomolecules using plasmonic phenomena around gold nanostructures on substrate. When a laser light is irradiated on the gold nanostructures, localized surface plasmon resonance is excited, enabling the thermophoretic manipulation of nanoscale materials induced by the optothermal effect. In this study, substrates with gold nanostructures were fabricated by electron beam lithography, and the manipulation behavior of a protein, Dps, labeled with the fluorescent protein TGP, was observed. In the experiment, it was confirmed that the Dps was accumulated in a ring-like shape. Also, as the laser power increased, the diameter of the ring-like shape became larger. Then, the relative intensity at the center of the irradiation was decreased.

  • 竹之内 隆伸, 吉野 大輔
    セッションID: J024p-03
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    One way to ensure the reproducibility of cell experiments is to automate the workflow, which can be achieved using microfluidic device technology. However, microfluidic device technology is only used in a few studies because it requires a lot of time and money, in addition to the know-how needed to develop the technology. In this study, modular microfluidic devices that are inexpensive and freely combinable were developed by integrating micromilling and soft lithography technologies, and the performance of a prototype cell counting device was evaluated. The combination of such single-function devices (modules) and the use of machine learning is expected to improve the efficiency of microfluidic device development.

  • 田中 遼, 藤田 凌嘉, 松永 大樹, 出口 真次
    セッションID: J024p-05
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    It is important to understand how bio-molecules diffuse and are transported inside the cells in order to reveal the role of these molecules. Fluorescence correlation spectroscopy (FCS) is one of the methods to analyze such diffusion phenomena. In FCS, the diffusion coefficient of the target molecule can be estimated from the time-series data of fluorescence intensity by fitting the auto-correlation function with a model equation. Since FCS requires long time-series data to estimate the diffusion coefficient, we suggest a new FCS method, machine learning-aided FCS. In this new method, we train the neural network to understand the relationship between the time-series data of the intensity and the diffusion coefficient. Our approach can estimate the diffusion coefficient with time-series data that is 1/5 of the conventional FCS.

  • 趙 凱, 川田 到, 市川 賀康, 元祐 昌廣
    セッションID: J024p-06
    発行日: 2023年
    公開日: 2024/03/25
    会議録・要旨集 認証あり

    Within a MPS (microphysiological system), which mimics the in-vivo environment in vitro, the morphology of cells changes depending on the shear stress and its variations induced by the fluid flow. In this study, we aim to understand these morphological changes of cells seeded in a microchannel by flow control via an ACET (AC electrothermal) pump installed in the microchannel, and we evaluated the osteoblast differentiation of hMSCs (human mesenchymal stem cells) under the pulsatile flow condition using the ACET pump by comparing with that under the static condition. In the experiment, it was found that osteoblasts differentiated under the pulsatile flow condition show a higher rate of differentiation than those under the static condition, demonstrating that pulsatile flow promotes the differentiation of hMSCs into osteoblasts.

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