The cloning is one of the most promising biotechnologies today. The project aims to automate every process required in the cloning, i.e. cutting, removing, filtering, assembling and fusing, on the basis of micro RT. The processes are performed on a micro chip consisting of micro channels and chambers in which egg cells and membranes flow and are manipulated. A whole system would be small and compact enough to be fit on desk top to meet various demands in biotechnology. The objectives, the overview and the current progress will be introduced in this keynote.

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Disposable, built-in micropumps are key devices for biochip technology. In this study, we propose two types of all-polymer built-in micropumps driven by light. First one is a lobed micropump that generates flow by using positive displacement. The lobed microrotors are driven by a synchronized laser-scanning method. Second one is a viscous micropump that generates flow by using drag force surrounding the rotor. This pump generates flow just by rotating a single disk rotor or a double helical rotor in a U-shaped microchannel. These micropumps enable ultralow flow control on the order of pL/min. The ultralow flow rate will be useful for further integration and miniaturization of micro-total-analysis systems.

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[in Japanese]

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