Pancreatic exocrine function was investigated using PFD (Pancreatic Function Diagnostant) test in 162 patients with massive alcohol intake. The results obtained were as follows: (1) Significantly lower PFD values were observed in those patients with massive alcohol intake than in normal controls. Abnormally low PFD values below 70.0% were noticed in 81 (50.0%) out of an overall 162 patients. (2) No significant differences in PFD values were obtained among the patients who were classified into 3 categories according to age or duration of alcohol intake. (3) Only 25 (15.4%) patients indicated low bady weight below 89.9% of ideal body weight. PFD values in those patients tended to be lower than in other 2 groups. In conclusion, it was assumed that massive alcohol intake inhibited pancreatic exocrine function using PFD test.
Two experiments were conducted to study the effect of emulsifiers on the incorporation of tocopherols to the rat tissues. As Experiment I, two groups of vitamin E deficient rats were forcedly administered roughly equal mixture of α-, β-, γ- and δ-tocopherol with or without monoglyceride (MG) p. o., and after the treatment, tocopherols in small intestine and liver of these rats were temporally analyzed by high performance liquid chromatography. Experiment II was made by analyzing tocopherols in small intestine at 7 hours and in liver at 10 hours after the same treatment, except using soya lecithin (LE), sorbitan tristearate (SO) or a lipophilic sucrose fatty acid ester (SU) instead of MG. 1) Results of Experimeent I suggested that the addition of MG increased the uptake of each tocopherol to liver, but did not show increase of it in small intestine. The peak level of each tocopherol was generally attained at 7 hours for small intestine and at 10 hours for liver after the treatment. 2) In Experiment II, the uptake of each tocopherol to small intestine was significantly decreased by the addition of LE, but its decrease was not observed by addition of SO or SU. The addition of those emulsifiers seemed to increase the uptake of tocopherols to liver. 3) Examined distribution of each tocopherol in the liver at 10 hours after the treatment showed that the above effect of each emulsifier seemed to be higher by the order of MG>SU>SO≅ LE.