Nippon Eiyo Shokuryo Gakkaishi
Online ISSN : 1883-2849
Print ISSN : 0287-3516
ISSN-L : 0287-3516
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Volume 68, Issue 2
Displaying 1-4 of 4 articles from this issue
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Rapid Communication
  • Identification of a Novel Protein Binding to the Endocrine Disruptor Nonylphenol
    Taiji Ito, Shunsuke Yamazaki, Kazuki Ota, Masashi Ohmura, Seiichi Oyad ...
    2015 Volume 68 Issue 2 Pages 63-68
    Published: 2015
    Released on J-STAGE: April 20, 2015
    DOIhttps://doi.org/10.4327/jsnfs.68.63
    JOURNAL FREE ACCESS
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    Nonylphenol is an alkyl phenol generated through microbial degradation of non-ionic surfactants in rivers as well as by oxidation and hydrolysis of oxidants in plastic products. Therefore, it is important to assess the endocrine disruption effects of nonylphenol ingested via food and to clarify the molecular mechanism involved. Nonylphenol primarily targets the male reproductive (testes and prostate) system, and may be involved in insufficiency of sperm differentiation and degeneration of the testes and prostate in F1 and F2 mice exposed to nonylphenol at the prenatal stage. In this study, we isolated the human protein NPR1 (Nonylphenol Receptor 1) from a normal human prostate cDNA library as a protein binding to a hormone receptor binding domain of histone acetyltransferase AIB1 in the presence of nonylphenol. Molecular interaction analysis revealed that NPR1 binds nonylphenol with high specificity. Therefore, in addition to the endocrine disruption mechanism occurring through the estrogen receptor, a new mechanism acting via NPR1 was suggested.
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Research Note
  • Effect of the Dietary Rare Sugar, D-Psicose, on Life Span of Rats Fed a High-fat Diet
    Shunsuke Higaki, Tatsuhiro Matsuo
    2015 Volume 68 Issue 2 Pages 69-72
    Published: 2015
    Released on J-STAGE: April 20, 2015
    DOIhttps://doi.org/10.4327/jsnfs.68.69
    JOURNAL FREE ACCESS
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    The safety of the rare sugar, D-psicose, when fed to rats over a long period (6-18 months) has been reported. However, as D-psicose may be ingested daily as a sweetener, it is necessary to examine its long-term safety. In this study, we investigated the effect of life-long intake of dietary D-psicose on the life span of rats fed a high-fat diet. Sixty-one male Wistar rats were divided into three groups; a high-carbohydrate diet (HC) group, a high-fat diet (HF) group, and a high-fat-3% D-psicose diet (HFP) group. These diets were fed to the rats (n = 20-21) from 4 weeks of age until death. Body weight at 30 months was higher in the HF and HFP groups than in the HC group, but there were no significant differences in serum biochemical test results between the groups. Although average survival time was lower in the HC group than in the HF and HFP groups, the difference was not significant. These results suggest that the life span of Wistar rats is not affected by a small amount of D-psicose in their diet.
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Research Data
  • The Efficacy of Food for Specified Health Use Recognized by Female Students Studying Health Sciences via Advertisements and Scientific Articles
    Taro Murakami, Kengo Ishihara, Keitaro Matsumoto, Koji Okamura, Yuri Y ...
    2015 Volume 68 Issue 2 Pages 73-81
    Published: 2015
    Released on J-STAGE: April 20, 2015
    DOIhttps://doi.org/10.4327/jsnfs.68.73
    JOURNAL FREE ACCESS
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    Food for Specified Health Use (FOSHU) includes items approved by the Consumer Affairs Agency of Japan as having health benefits. However, some reports have indicated that FOSHU items do not always show efficacy in daily life, and many users of FOSHU have also made similar claims. It is possible that consumers may not always be aware of the specific conditions of usage required in order for efficacy to be observed. Therefore, we investigated whether female university students majoring in health sciences were able to recognize the conditions of effective usage for some FOSHU items based on advertisements and scientific information in the literature. We found that about 30% of the students were unable to recognize the conditions and usage for FOSHU efficacy. Therefore, it seems that accurate information necessary for obtaining benefits from FOSHU is not being conveyed to students, perhaps accounting for the fact that FOSHU efficacy is not always observed in daily life.
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Erratum
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