日本口腔インプラント学会誌
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25 巻 , 3 号
選択された号の論文の7件中1~7を表示しています
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原著
  • 早野 圭吾, 小野 擴仁, 山倉 和典, 中島 三晴, 永沢 栄
    原稿種別: 原著
    25 巻 (2012) 3 号 p. 445-452
    公開日: 2013/12/02
    ジャーナル フリー
    Objective: The influences of abutments made from zirconia (Y-TZP) and cement materials on the strength of titanium implants were investigated by using the finite element method.
    Methods: Non-linear analysis was performed using a finite element method program (ANSYS Ver. 11, ANSYS, Canonsburg, U. S. A.) and a personal computer. For the analysis model, the bisection, trisection, and modified trisection types, for which the reliability of analytical accuracy has been established by experiments, were used. Regarding the combination of constituent materials, fixtures made of JIS class-4 pure titanium were used for all samples, and the materials of the abutment and abutment-screw were changed. Temporary cement and resin cement were used for adhesion materials. The materials of the superstructure and abutment were the same, and compact bone was used under all conditions. A force of up to 1,000 N was loaded in the 45° oblique direction to the superstructure. The fixture, abutment, and abutment-screw were placed in contact, the bone bottom was entirely fixed, and the lateral sides were fixed excluding the longitudinal direction.
    Results: When JIS class-4 pure titanium abutment-screws were used in the trisection type implant, the strength reached the maximum. In the case of the bisection and modified trisection types implants, the strength decreased greatly when using abutments made from zirconia, although their fracture strengths were equivalent to the fatigue strength of JIS class-4 pure titanium implants. The influence of the two types of cement on strength of implant depended on the structure and materials of the implant. However, no major difference due to the cement type was noted in the strength of any implant.
    Conclusion: When the abutment and superstructure are prepared with zirconia, the maximum strength can be obtained by using JIS class-4 pure titanium abutment-screws in the trisection type. The design appropriate for all titanium implants is not necessarily appropriate for zirconia abutments; an appropriate design for zirconia abutments needs to be investigated. For the two kinds of cement examined, the strength of implant was hardly affected by the kind of cement.
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  • 髙橋 徹次, バワール ウジャールクマール, 水上 哲也, 渡辺 孝夫, 髙橋 常男, 安孫子 宜光
    原稿種別: 原著
    25 巻 (2012) 3 号 p. 453-460
    公開日: 2013/12/02
    ジャーナル フリー
    β-TCP は骨形成を促進すると報告されているが,その機序については不明な点が多い.ビーグル犬の下顎骨の骨欠損部にβ-TCP を填入することで骨形成を促進され,また,顎骨組織中のIGF 遺伝子の発現増大が報告されている.IGF は,骨芽細胞で豊富に産生され,細胞増殖,分化に重要な役割を発揮する成長因子である.しかし,β-TCP による顎骨のIGF シグナリングの活性化の機序については不明である.本研究では,インプラントドリルでビーグル犬下顎骨に骨欠損を作成してβ-TCP を填入した.そしてIGF 受容体1 (IGF1R)の遺伝子発現への影響についてRT-PCR およびリアルタイムPCR 法を応用して調べ,さらにタンパク質発現を免疫組織学的に検証した.
    その結果,対照群に比べて,IGF1R 遺伝子の発現がβ-TCP によって促進し,さらに,IGF1R タンパクおよびIGF1R リン酸化の促進が確認された.これらのことから,β-TCP によるIGF1R 遺伝子発現およびリン酸化は骨形成促進の機序の一部であることが示唆される.
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  • 古屋 延明, 和田 猛, 小澤 大作, 山西 泰史, 早川 徹
    原稿種別: 原著
    25 巻 (2012) 3 号 p. 461-467
    公開日: 2013/12/02
    ジャーナル フリー
    水晶発振子マイクロバランス(QCM)法は,共振している水晶発振子の振動数の減少からタンパク質の生体材料への吸着量を検出できる方法である.本研究では,27 MHz QCM を使用して,チタン表面へのタンパク質の吸着挙動を観察した.タンパク質としては,細胞接着タンパク質であるフィブロネクチンとコラーゲン,およびアルブミンについて検討した.
    QCM 装置として,500 μL のセルを備えた27-MHz AFFINIX QNμ(イニシアム,東京)を使用した.温度は25±1℃ に設定し,セル中の溶液を攪拌しながら測定した.チタンセンサーは,金電極上にスパッタコーティングを施して作製した.牛アルブミン,ヒト血漿フィブロネクチンおよびアテロコラーゲンをそれぞれ50 μg/mL の濃度でリン酸緩衝液(PBS,pH 7.4)に溶解した.それぞれのタンパク質溶液を,PBS 溶液を満たしたQCM 装置付属のセル中に注入した.振動数の減少を観察し,注入30 分後のタンパク質吸着量をSauerbrey の式から算出した.さらに,見かけの反応速度定数Kobs を得た.
    アルブミンを注入した時は振動数のわずかな減少がみられ,フィブロネクチン吸着時の振動数減少のほうが,アルブミン吸着時よりも大きかった.コラーゲンが統計学的に有意に最も大きな振動数の減少を示した.3 種類のタンパク質の吸着量はそれぞれ統計学的に有意差があり,コラーゲンが統計学的に最も大きな吸着量であり,アルブミンが統計学的に最も少ない吸着量を示した.また,コラーゲンのKobs は,統計学的に最も小さい値であり,アルブミンが統計学的に最も大きな値であった.小さな Kobs の値は,タンパク質のチタンへの吸着速度が早いことを意味している.
    タンパク質のチタンへの吸着は静電的な相互作用が主要因であると推察される.アルブミンおよびフィブロネクチンはその等電点からチタンとの間に静電的な反発力が働いている.一方,コラーゲンとチタンの間には,コラーゲンが正に荷電しているために吸引力が増加した.以上,QCM はタンパク質の吸着量だけではなく,吸着速度も含めた吸着挙動の観察に非常に重要なツールであることが判明した.
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症例報告
  • 上田 秀朗, 野村 隆祥, 城戸 寛史, 矢野 尚一, 山本 勝己, 松浦 正朗
    原稿種別: 症例報告
    25 巻 (2012) 3 号 p. 468-475
    公開日: 2013/12/02
    ジャーナル フリー
    Although dental implant placement is considered to be a safe surgical procedure, this report focuses on two cases with severe hemorrhage during implant placement in the mandible. Excessive hematoma formation in the mouth floor resulted from arterial or venous trauma that occurred during implant socket preparation. The first case was a 60-year-old man who suffered hemorrhage and the formation of a large hematoma in the mouth floor that occurred during insertion socket preparation in the lateral incisor position on the right side of the mandible. The second case was a 57-year-old woman in whom a large hematoma formed in the mouth floor 4 hours after implant placement in the first molar site on the right side of the mandible.
    In the first case, the dentist did not consider that the lingual cortex had been perforated. Therefore, we suspected that a small branch of the sublingual artery had been injured in the mandible with a twist drill, and that the vessel had withdrawn into the mouth floor. In the second case, the dentist involved identified a perforation of the lingual cortex, although bleeding had been noticed during the surgery and hemostasis had been achieved at that time. Swelling occurred 4 hours after surgery, although it progressed relatively slowly. Therefore, we suspected that a small vein in the mouth floor had been injured. Severe airway obstruction did not occur in either case.
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  • 藤田 温志, 新谷 悟, 菊池 雄一
    原稿種別: 症例報告
    25 巻 (2012) 3 号 p. 476-480
    公開日: 2013/12/02
    ジャーナル フリー
    Though dental implant treatment is mainly intended for functional improvement of disorders in the stomatognathic system resulting from missing teeth, it sometimes leads to unpredictable neurological symptoms in patients. We report two cases of atypical orofacial pain following dental implant placement. The patients were two women aged 50 and 65 years old. Neither patient had established a rapport with the dentist who performed the dental implantation for them. The patients were treated by administration of paroxetine hydrochloride hydrate and milnacipran hydrochloride, in consultation with the physician. We must be conscious of the onset of orofacial pain in dental implant treatment.
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調査・統計
  • 松島 弘季, 阿部 洋太郎, 渡辺 浩, 服部 重信
    原稿種別: 調査・統計
    25 巻 (2012) 3 号 p. 481-487
    公開日: 2013/12/02
    ジャーナル フリー
    The objective of this study was to identify clinical indices for the safe and appropriate determination of insertion sites in mandibular molar implant treatment. The subjects were 286 patients (153 men, 133 women; age 26-78 years) who underwent cone-beam CT scanning prior to implant surgery. The patients were immobilized at the forehead and external auditory meatus in the upright position, and the cone-beam CT image was screened in the occlusal plane horizontally in the state of centric occlusion.
    The angle of inclination of the mandible and vertical bone diameter on the lingual side, which are anatomical factors that affect implant insertion planning, were measured on the cone-beam CT images.
    As a result, the angle of inclination of the mandible increased from the mesial to the distal side which was consistent with previous reports.
    The angle of inclination of the mandible was ≧30º in the second molar in 26.0% of patients. Vertical bone diameter on the lingual side was ≦12 mm in the first molar in 43.78% of patients and ≦12 mm in the second molar in 62.66% of patients, and a high proportion of mandibles posed problems for implant planning.
    The morphology of the lingual side of the mandible is difficult to diagnose from panoramic X-ray images. We must perform accurate preoperative diagnosis, including CT scanning, and carry out implant treatment with a high degree of predictability, with safety as the basic premise.
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資料
  • 森田  康之
    原稿種別: 資料
    25 巻 (2012) 3 号 p. 488-495
    公開日: 2013/12/02
    ジャーナル フリー
    Background: Although it is important to elucidate the deformation distribution of alveolar bone around a dental implant, there are some disadvantages in the existing experimental methods such as strain gauge method, photoelasticity method, etc. Therefore, an advanced experimental technique is required not only for problems but also for showing the validity of numerical analysis such as finite element analysis.
    Objective: A new advanced experimental technique combining a bone model and digital image correlation (DIC) method is proposed to enable systematic, quantitative evaluations.
    Method: A laminated test block (SAWBONES, WA, USA) having the same bilayer structure as actual bone was employed as the bone model specimen. The DIC method was used to visualize the displacement and strain distributions of alveolar bone around a dental implant.
    Results: The new proposed experimental technique made it possible to analyze the deformation distribution around a dental implant systematically and quantitatively.
    Conclusions: The proposed experimental technique can be used to assess the deformation distribution behavior of alveolar bone around a dental implant systematically and quantitatively.
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