Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
Online ISSN : 1882-2738
Print ISSN : 0914-2649
ISSN-L : 0914-2649
Volume 25, Issue 1
Displaying 1-19 of 19 articles from this issue
  • [in Japanese], [in Japanese]
    2011 Volume 25 Issue 1 Pages 9
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • Kazuo Sugimoto, Naoki Shimojo, Minako Tomiita, Yoichi Kohno
    2011 Volume 25 Issue 1 Pages 10-15
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    Thirty years ago there were few good anti-asthma medication such as inhaled corticosteroids or leukotriene receptor antagonists. From that time we have conducted allergen specific immunotherapy to treat patients with asthma or allergic rhinitis who have been sensitized specific allergens. Because of the quick effects, rush immunotherapy is more favorable than conventional method. We found that house dust-mite specific IgG4 antibody increases and house dust-mite specific IgE antibody decreases after successful immunotherapy. We also revealed that one of the mechanisms of immunotherapy is sift of Th1/Th2 cytokine balance and increase in regulatory cytokine IL-10.
    Rush immunotherapy has several disadvantage such that patients need to be admitted in the hospital during rapid antigen escalation phase. However, recently cluster methods has been developed by Nagata which makes it possible to treat patients on the outpatients basis.
    Now, in Japan, there are two big problems about immunotherapy. First, standardized allergens are not available except mite and Japanese ceder pollen. Second, sublingual immunotherapy is not available in Japan, while it has been approved by governments in Europe and the United States.
    Since immunotherapy is the only way to lead patients to natural remission, we hope many allergen extracts for immunotherapy including sublingual will be available soon in Japan.
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  • [in Japanese]
    2011 Volume 25 Issue 1 Pages 16-23
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    2011 Volume 25 Issue 1 Pages 24-29
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • [in Japanese], [in Japanese]
    2011 Volume 25 Issue 1 Pages 30-31
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • [in Japanese]
    2011 Volume 25 Issue 1 Pages 32-35
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • Naoko Inomata
    2011 Volume 25 Issue 1 Pages 36-49
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    The term "component-resolved diagnostics (CRD)" has been coined to describe the diagnosis of allergic diseases with diagnostic tests based on pure allergen molecules, such as recombinant allergens and purified allergens. CRD introduces new possibilities for diagnosing allergic diseases including food allergy. In food allergy, CRD might be effective in improving diagnosis efficiency and presuming the clinical features of food allergies, such as clinical type, severity and prognosis, and the possibility of cross-reactivity. In research of CRD using plant-derived components, the recombinant allergen molecules with high cross-reactive potential have been used as marker allergens, and more recently, the concept of "marker allergens" has been applied to important and well-characterized components related to factors other than cross-reactivity, such as severity and prognosis, in food allergy. In the terms of assays, while specific IgE assays have been designed predominantly as single allergen tests, protein array technologies allow the simultaneous measurement of IgE antibodies of many specificities using complex arrays comprising large numbers of allergens. The further introduction of CRD in allergological practice provides the potential basis for individualized diagnostics and treatment in the future.
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  • [in Japanese]
    2011 Volume 25 Issue 1 Pages 50-56
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • Reiko Teshima
    2011 Volume 25 Issue 1 Pages 57-62
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    As for food allergens, the Japanese Ministry of Health Labour and Welfare (MHLW) made a decision for mandatory labeling of foods containing allergenic ingredients in 2001. Egg, milk, wheat, buckwheat and peanut, and most recently shrimp and crab require mandatory labeling. The MHLW announced the Japanese official method for the detection of specific allergenic ingredients in a ministry notification. The Japanese official methods consisted of two kinds of ELISA kit screenings, the Western blot method for egg and milk, and PCR method for wheat, buckwheat, peanut, shrimp and crab as confirmation tests are listed in the ministerial notification of November 2002 and revised notification of January 2009. From now on, the notification of mandatory allergenic ingredients and detection method would be also revised timely.
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  • Setsuko Ito
    2011 Volume 25 Issue 1 Pages 63-67
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    The principle of the management of food allergy is minimal elimination diet based on proper diagnosis of offending allergen. Dietary counseling aiming at “eating” is essential to maintain QOL of patients with food allergy. To put this ideal into practice, detailed information about the antigenicity of offending allergen in cooked foods from the patients' standpoint of view is required. Establishment of quantitative evaluation system of antigen in cooked foods and reduction of antigenicity by cooking was confirmed about hen's egg, cow's milk and wheat flour on the allergen component level using this evaluation system.
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  • [in Japanese], [in Japanese]
    2011 Volume 25 Issue 1 Pages 68
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • [in Japanese]
    2011 Volume 25 Issue 1 Pages 69-74
    Published: 2011
    Released on J-STAGE: June 27, 2011
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  • Hirokazu Arakawa
    2011 Volume 25 Issue 1 Pages 75-80
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    By recent birth cohort studies, it has been demonstrated that the most important environmental factors that predispose to the development of asthma are lower respiratory tract viral infections associated with wheezing, especially in early childhood, and repeated inhalation exposure to allergens, which appear to be synergistic. These factors may also influence the exacerbation of asthma. The recent studies that clarify the mechanism of interaction between these factors in the development of asthma have been focused on the role of gene-environmental interaction and epigenetics. Further studies will be needed to clarify the exclusion mechanisms of viruses, especially rhinovirus which lead to damage airway epithelium, from the airway, resulting in preventing the development and exacerbation of asthma.
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  • Syuji Yonekura, Yoshitaka Okamoto
    2011 Volume 25 Issue 1 Pages 81-84
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    Allergic rhinitis is an independent risk factor for development of bronchial asthma, and the beneficial interventions for reducing development of allergic rhinitis are also effective for the prevention of subsequent onset of bronchial asthma. The results of our prospective study indicate that preventing an increase of house dust mite specific IgE is likely to be beneficial interventions for prevention of allergic rhinitis and bronchial asthma. Upper respiratory infection is thought to be a factor which aggravates the symptoms of allergic rhinitis.
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  • Hide Kaneko, Hidenori Ohnishi, Hideyuki Morita, Minako Kawamoto, Kazun ...
    2011 Volume 25 Issue 1 Pages 85-89
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    The onset of food allergy is modified by the genetic and environmental factors. It is known that breast milk influences the onset of food allergy. We investigated the cytokine level in breast milk. It was shown that the level of IFN-gamma and TGF-beta 1, 2 in breast milk at 1 week after delivery were different from breast milk at 1 month after delivery. The change of cytokine level in breast milk might modify the onset of oral tolerance induction.
    Beta-lactoglobulin (BLG) is one the major allergen in cow's milk. We developed the BLG which has have T cell epitope but does not have B cell epitope using enzyme digestion. This BLG showed the oral tolerance induction in some patients with cow's milk allergy. Furthermore, we try to develop the effective and safe method of oral tolerance induction in food allergy.
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  • Naoyuki Inoue, Asuka Yamamoto, Sayako Matsumoto, Nobuo Ishigaki
    2011 Volume 25 Issue 1 Pages 90-97
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    We experienced a case of food-dependent exercise-induced anaphylaxis (FDEIA) caused by ingestion of canned yellow peach. The result of Immuno CAP® (CAP) for peach was negative, and there was no scratch extract for peach. Therefore, the prick-prick test was performed using canned yellow peach; it gave a positive result. The selection of food items is very important in provocation tests because the positive rate of provocation test for FDEIA is low. We retrospectively analyzed reports of Japanese patients with FDEIA, except wheat-dependent exercise-induced anaphylaxis, published in medical journals from 1983 to 2009. The positive rate of the prick-prick test performed alone was lower than that of the skin prick test and CAP. However, the combination of the prick-prick test and CAP increased the number of cases with positive results and was useful in determining food items for provocation tests.
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  • Shigeharu Oh, Sae Nishisho, Tomohide Taguchi, Mitsuaki Kimura
    2011 Volume 25 Issue 1 Pages 98-103
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    A case of intestinal cow's milk allergy (ICMA) in early infancy complicated by methemoglobinemia was reported. An one-month-old bottle-fed male infant was referred to our institute because of high fever, diarrhea, vomiting and growth failure. He showed cyanosis refractory to the administration of oxygen. Laboratory examinations revealed not only a rise in the CRP level, but also a marked increase in the methemoglobin level (up to 32.4%). All these symptoms and abnormal laboratory findings including methemoglobinemia were solved by discontinuation of feeding without any other specific therapy.
    Although soy milk caused the same symptoms, he was fed uneventfully with amino acid formula. Allergen-specific lymphocyte stimulation test for cow's milk protein (kappa-casein) was shown to be positive. A challenge of cow's milk formula performed at 2 months of age caused high fever, diarrhea, vomiting and cyanosis. Methemoglobinemia and an increase in the CRP level were also confirmed by laboratory examinations. These findings suggest that the cell-mediated immunity against cow's milk proteins plays a significant role in the development of methemoglobinemia as well as other symptoms. Although methemoglobinemia is an uncommon complication of ICMA, physician should pay enough attention because it is a possible life threatening disorder.
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  • Tetsuo Shoda, Atsushi Isozaki, Sho Mimura, Norifumi Ogawa, Takeshi Nom ...
    2011 Volume 25 Issue 1 Pages 104-107
    Published: 2011
    Released on J-STAGE: June 27, 2011
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    It is not clear how pandemic influenza A (H1N1) 2009 infection affects children with bronchial asthma. A total of 188 children with bronchial asthma who were well-controlled by treatment during peak season was studied; 57 (30.3%) were positive for pandemic influenza A (H1N1) 2009. There was a significant difference in age (p=0.02) between children who were positive and those who were negative for pandemic influenza A (H1N1) 2009. Of the influenza-positive children, 11 (19.2%) had an asthma attack. There was no difference in asthma severity among the children who had an asthma attack with pandemic influenza A (H1N1) 2009 infection. Only two patients (3.5%) were hospitalized, but they were not seriously ill. About one year has passed, and it is expected that adequate management will be provided for the second outbreak, regardless of disease severity.
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