Purpose: To investigate the present situation and to explore future problems in bereavement care. Methods: A questionnaire survey was mailed to approximately 1,000 home-visit nursing stations throughout Japan. Results: A total of 296 (29.8%) valid responses were returned. Of the responding stations, 6.1% answered that they “positively perform” bereavement care, 73.1% “perform [it] when necessary,” and 20.7% “seldom perform” bereavement care. A total of 91.4% of the responding stations provided bereavement care by visiting nurses after a patient’s death. A total of 73.6% of the responding stations always performed care in the form of appreciation for their efforts. A total of 32.4% of the responding stations contacted related organizations to request that the organizations watch bereaved family members who suffered from dementia but lived alone. Reasons for not contacting related organizations included not knowing which organization to contact (17.5% of the responding stations). Conclusion: Approximately 90% of the responding stations provided bereavement care by visiting nurses after the patient’s death, with emotional support as the main activity. Visiting nurses were asked to acquire abilities: 1) to provide bereaved families with information about health and welfare services that could be used in addition to long-term care insurance to rebuild their lives, 2) to ascertain which bereaved families would need continuous support, and 3) to assign these bereaved families to relevant organizations.

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Objectives: The purposes of this study are to assess the prevalence and tasks of bereavement services in Japanese hospices/PCUs and to explore these changes through comparison of survey data in 2002 and 2012. Methods: A postal survey of all government-approved hospice and care units in Japan was conducted in 2012. Two hundred twenty-seven questionnaires were dispatched, of which 156 were retuned (response rate, 68.7%). Results: The results of 2012 survey showed that 78% of respondents sent memorial cards, and 73% provided memorial services. The ratios of hospices/PCUs offering diverse bereavement serveces in general decreased over the last decade. “Organizational support” was perceived by 71% of respondents as one of the tasks of bereavement services in 2012 survey. The responses of “caregiver training” and “research on the demands of bereaved individuals” as perceived tasks were declined significantly over the past decade from 2002. Conclusion: These findings in 2012 survey revealed present status of bereavement services in Japanese hospices/PCUs, and suggested that some perceived tasks has been slightly dealt with through comparison with results of 2002 survey.

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The present multicenter, open-label study evaluated the efficacy and safety of tapentadol ER administered at 50 mg/day to 500 mg/day in opioid-naive and opioid-switching subjects with moderate to severe cancer pain. For opioid-naive subjects, the initial dose was tapentadol ER 50 mg/day. For opioid-switching subjects, the initial dose was determined depending on previously used opioid and was dose-adjusted for each subject. The study design consists of two parts of titration period and maintenance period to which a patient who achieves dose adjustment can proceed. The percentage of subjects achieving dose adjustment in the titration period was 93.3% for opioid-naive subjects and 80.6% for opioid-switching subjects. The percentage of subjects who maintained adequate analgesia throughout the maintenance period (primary endpoint) was 89.7% for opioid-naive subjects and 92.9% for opioid-switching subjects. The most frequent adverse events were were nausea, vomiting, somnolence, and constipation, all of which were commonly reported with the use of opioids. These findings showed that tapentadol ER was well tolerated in the dose range of 50 mg/day to 500 mg/day.

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Purpose: This survey aimed to develop a methodology for measuring the quality indicators of end-of-life care for cancer patients using the Japanese National Database, which was comprised of the health insurance claim data of all Japanese people. Methods: Life-sustaining treatment (LST) and chemotherapy near the time of death are accepted as reliable indicators of poor quality end-of-life care. To measure these, the Sampling Data Set (SDS) from the National Database (NDB) was used. Results: 1,233 cancer patients were studied, who had died from 14th to 31st October, 2012. The rates of LST and chemotherapy in the final 14 days of life were 8.2% (95%CI 6.7-10.1), 3.5% (2.6-4.8) for inpatients (n=1,079) respectively. In the SDS, 27-70% of chemotherapy drugs were not named, in order to prevent identification of patients receiving rare treatment. Discussion: The figures for rates of chemotherapy might be underestimated in the sampling data set, because of the anonymization of rare treatment. And in-patient and out-patient data may in some cases have been duplicated when entries applied to the same person. In the future using the NDB, it might be possible overcome some of these limitations.

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Background: We retrospectively compared endscopic gastroduodenal stenting with gastrojejunostomy as a means of palliating malignant gastric and duodenal obstruction. Methods: This retrospective study investigated patients treated for malignant gastric and duodenal obstruction from April 2011 to April 2015 at Shikoku Cancer Center. Results: Of the 40 patients in this study, 25 underwent gastroduodenal stenting and 15 had operative gastrojejunostomy. Comparing the stenting and operative patients, technical success rate was 100% in both group, clinical success rate was 84% in stenting patients and 93% in operative patients. The median time to fluid intake was significantly shorter in stenting patients than operative patients(0 day vs 2 days, p=0.0003), and the median time to intake of solids was also significantly shorter in stenting patients(1day vs 3 days, p<0.0001).The median hospital stay was significantly shorter in stenting patients(9 days vs 23 days, p=0.0116). Median cost of hospitalization is more expensive in operative patients than stenting patients(¥1,106,170 vs ¥752,290, p=0.0052). Conclusion: Our study suggested that gastoroduodenal stent was less length of time to fluid/solid intake, and less costly than gastrojejunostomy.

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Objectives: The purpose of this study was to investigate current fact of cancer outpatients’ opioid pain management and its possible abusive applications and to establish corrective treatments by the palliative care team. Methods: Our palliative care team investigated cancer outpatients’ prescribed opioid clinical records for 4 months in 2014, and the result revealed inappropriate opioid use which could lead to further abuse or dependency. Through this the team recommended attending physicians viable options including decrease of opioid eventually leading to final withdrawal. Results: Among 67 cancer outpatients, the finding of inappropriate opioid use which could lead to further abuse or dependency was in 5 patients (7.4%). The details are as follows: (1) Three patients were treated with opioid analgesia for initial pain relief but the application continued in spite of recovering from a cancer which had been responsible to the pain. (2) Two patients were medicated with opioid for pain but further diagnosis revealed the disease which caused pain was benign. Four out of 5 patients were successfully withdrawn from opioids. Conclusion: In cancer outpatient settings, it can be overlooked or undetected inappropriate use of opioids which may lead to abuse or dependency without a team approach. To prevent opioid abuses, it is imperative to find the cause of pain as accurately as possible.

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Introduction: SEIQoL-DW is a method of measuring the subjective QOL by focusing on five areas considered important by the patient in a semi-structured counseling session. The objective of this study was to evaluate areas considered important by patients undergoing anti-cancer therapy and the subjective QOL. Methods: SEIQoL-DW was carried out consecutively on patients who met the inclusion criteria such as pain STAS-J 1 or lower at palliative care outpatient service. Results: The study was implemented on 68 subjects (35 anti-cancer therapy patients, and 33 palliative care patients). Commonly selected areas by anti-cancer therapy patients were “family” at 94%, “cancer treatment” at 69%, “health” at 43%, “friends” at 43%, “hobbies” at 40%. The mean subjective QOL of anti-cancer therapy patients was significantly lower than that of palliative care patients (61.5 vs 74.4). Conclusion: The area “family” makes great impact on the QOL. On the other hand, putting high importance on “cancer treatment” may have a negative impact on the QOL.

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Objectives: To determine the factors that influence the decision maker regarding end-of-life (EOL) care and to disclose how aggressive care in the last week before death, place of death, and quality-of-life (QOL) affected the decisions made. Methods: The subjects were 409 bereaved family members (cause of death included cancer, stroke, heart disease, and pneumonia) that registered with an internet research agency. Decision-making was controlled either by the patient, family, or physician or shared by the patient, family, and physician. Results: The results of a multinomial logistic regression analysis demonstrated that when a family controlled decision-making, they were less likely to report patient-family EOL discussion [odds ratio (OR)=0.52], and that the patient had good communication with the physician (OR=0.77); they were also likely to report that the patient had dementia (OR=1.94). Families who reported physician-controlled decision-making (vs patient controlled) were less likely to report that the patient had good communication with the physician (OR=0.62). Cardiopulmonary resuscitation in the last week and place of death were not associated with the decision maker. EOL QOL was associated with EOL care of the decision maker. When a physician controlled decision-making, patient EOL QOL was at its lowest. Conclusion: To improve patient-controlled decision-making, it is critical that patients, families, and physicians have more communication regarding EOL care.

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Purpose: To elucidate the problems recognized by visiting nurses when local communities support the bereaved families of users of home-visit nursing stations. Methods: A questionnaire survey was mailed to approximately 1,000 home-visit nursing stations throughout Japan. Results: We then analyzed 211 free descriptions and extracted 8 problems, including “Grief care is difficult to continue because it is a voluntary activity,” “It is insufficient in assessing bereaved families and I don’t know the social resources to introduce to bereaved families,” “I am reluctant to be involved with bereaved families,” “Because of the Act on the Protection of Personal Information, it is difficult to support bereaved families,” and “A formal & informal support for bereaved families has not been established.” Conclusion: No system has been established for grief care in Japan and grief care does not generate a profit; therefore, visiting nurses felt limited in their ability to be continuously involved in grief care, although they were concerned about the situations of bereaved families. This study indicated future tasks that home-visit nursing stations that perform grief care for the bereaved families of their users and home-visit nursing stations that request this care be provided by community general support centers should be evaluated in terms of medical remuneration points.

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Introduction: The opioid-to-methadone conversion ratio is not constant. Thus, exacerbation of pain associated with switching of these drugs is a concern. We report two cases in which methadone was introduced in combination with epidural block. Case 1: The patient was a 55-year-old man who complained of perineal pain due to recurrent colorectal cancer. Diagnostic imaging could not be performed because of severe persistent pain and breakthrough pain even under treatment with oral oxycodone 600 mg/day. Methadone administration (starting dose, 45 mg/day) was started in combination with continuous lumbar epidural block. The persistent pain mostly dissipated after an approximately 2-week treatment period with methadone 75 mg/day, making magnetic resonance imaging measurement possible. Case 2: The patient was a 62-year-old man who complained of pain in both lower limbs due to spinal metastasis of prostate cancer. Pain impairing body movement persisted even during treatment with oral oxycodone 300 mg/day. The pain was reduced by combination treatment with continuous lumbar epidural block and methadone (starting dose, 30 mg/day), making it possible to perform radiotherapy. At the time of discharge from the hospital while being treated with methadone 45 mg/day, the patient complained minimally of pain. Conclusion: Owing to epidural block, switching to methadone was achieved smoothly without exacerbation of pain.

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Purpose: The goal of rehabilitation for advanced cancer patients is to improve their quality of life (QOL). The meaning of QOL can only be determined by an individual patient. Rehabilitation begins with exploring the patient's hope. Here, we report a case suffering to express hope with difficulties by terminal stage lung cancer with brain metastases. Case: An 83-year-old male who was diagnosed with lung cancer (adenocarcinoma) and brain metastases admitted to palliative care unit because of progressive disease against chemo-radiotherapy. On admission, he could eat independently and walk to bathroom with slight assistance. A few weeks later, he had an epileptic seizure, right-hemiplegia and disturbance of consciousness. This episode made it drastically difficult for us to communicate orally with him. And, we tried hard to know the patient's hope by assessment using activities of daily living (ADL) observation and non-verbal communications. He revealed to be eager to eat even in a PS grade 4. He sometimes could talk a few words and, by rehabilitation techniques, he started to enjoy eating independently. For about three weeks, he could eat until the day before he died. Discussion: Eating behavior could be influenced by proper way of rehabilitation. Conclusion: ADL observation and non-verbal communication could be an effective rehabilitation approach to stimulate feeding behavior resulting in the improvement of patient's QOL.

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Introduction: We report a case of acute-phase reaction of denosumab which was difficult to exclude aggravation of original cancer pain. Case: A 65 year-old man with severe pain from right back to upper abdomen due to mid thoracic vertebral metastases of small cell lung cancer was consulted to palliative care team. Denosumab 120 mg was administered subcutaneously three times every four weeks. On the next day of first administration, pyrexia occurred. At all three administrations, pain worsened for four days after the next day of administration. The pain was worsened from numerical rating scale 2 to 6. Same phenomenon was observed each time denosumab was administered for three consecutive times. Although the area of pain overlapped with that of original vertebral metastases, the repetition of the pain exacerbation soon after the denosumab administration suggested acute-phase reaction. Conclusion: Pain aggravation caused by acute phase reaction of denosumab might be overlooked in patients with cancer pain. More investigation is needed for details of acute-phase reaction caused by denosumab.

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Introduction: This report describes a case of hyperactive delirium induced by tapenatadol whose symptoms were successfully managed with opioid-switching to oxycodon. Case: A 67-year-old female, who had been treated with chemotherapy for malignant thymoma, had to stop chemotherapy because of her carcinomatous pericarditis. Tapentadol 200 mg per day was administrated for her unbearable chest wall tumor invasion-related somatic pain. After a while, insomnia, visual hallucination, thought disturbance, and attention disturbance were appeared. We diagnosed as hyperactive delirium. Because her somatic pain was favorably controlled by tapentadol, we additionally administered quetiapine 50 mg per day instead of replacing tapentadol. Unfortunately, quetiapine was not effective for the delirium. We therefore switched opioids from tapentadol to oxycodon. The delirium was remitted soon after the switching without relapsing of the pain. Conclusion: Tapentadaol reportedly induce hyperactive delirium via its noradrenaline reuptake inhibitory action. This case suggests that switching tapenatadol to other opioid could be an effective option for opioid induced delirium.

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Introduction: Patients of end-stage heart failure often develop dyspnea. Although morphine is used for dyspnea, these patients are often inappropriate group for using morphine due to renal failure. Case: A seventy-year-old male with end-stage heart failure due to dilated cardiomyopathy developed dyspnea. We used continuous oxycodone infusion for dyspnea with small dose as an alternative to morphine due to renal failure. His dyspnea was relieved in dose-dependent without heart failure recovery. Conclusion: Oxycodone may be an alternative therapy for dyspnea with end-stage heart failure with renal failure.

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Purpose: Approximately 30% of the patients who received intervention from a palliative care team for problematic symptoms (e.g., pain, nausea, depression) also underwent rehabilitation at our acute hospital. We investigated their changes in activities of daily living (ADLs) and outcomes (i.e., death, changing hospitals, or being discharged to their homes). Method: We retrospectively analyzed the patients’ medical records data to examine patient training content, Barthel Index (B.I.) scores, and outcomes. Results: For one year, 86 patients received rehabilitation and 42 (48%) underwent anticancer therapy. B.I. scores increased for 35% of the patients, were stable for 20%, and decreased for 45%; 95% of the patients with decreased B.I. scores could not be discharged home. Conclusion: Advanced cancer patients are likely to experience a decline in ADLs and require longer rehabilitation periods to improve. A team approach is important for preventing disuse syndromes within a palliative care setting.

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