Purpose: Patients who receive chemotherapy for colorectal cancer with the prophylactic dexamethasone (DEX) for antiemesis may experience an abnormal elevation in their casual blood glucose levels. The purpose of this study was to determine the frequency of such a DEX-induced elevation in patients with metastatic colorectal cancer, and to emphasize the importance of pharmaceutical care in improving the quality of life of patients. Methods: We retrospectively analyzed data from 50 patients who had received chemotherapy with or without DEX. Results: Of the 30 patients who received DEX, 8 exhibited abnormally high blood glucose levels (>200 mg/dl on more than 2 occasions); 3 of these patients also had diabetes mellitus. None of the 20 patients who did not receive DEX exhibited a remarkable elevation in the blood glucose levels. Conclusions: We confirm that patients receiving concomitant administration of DEX with chemotherapy may exhibit elevated blood glucose levels. Because an increase in the blood glucose levels may produce symptoms indicative of diabetes such as fatigue, appropriate pharmaceutical care for early detection of the abnormal elevation in the blood glucose levels may be important in preventing complications in such patients.

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Purpose: The continuous subcutaneous infusion (CSCI) is one of the most popular methods to reduce cancer pain. Inflammatory skin changes such as redness and induration are sometimes observed around the infusion site of the skin. Although dexamethasone is empirically added to a CSCI regimen to reduce such skin changes, little evidence on this practice has been available. We aimed to demonstrate the effectiveness of the CSCI protocol that we have been using for the treatment of skin changes. Methods: We prospectively observed the incidence of skin changes. When redness or induration at the injected site appeared, a winged needle was switched to a plastic intravenous catheter. When the redness or induration did not resolve with this needle change, dexamethasone was added to CSCI. Result: Sixty-six patients with cancer pain who underwent CSCI using a winged needle were enrolled in this study. The CSCI needles were switched from a winged needle to a plastic intravenous catheter in 20 out of 66 patients who revealed redness at a size of greater than 10 mm in diameter during CSCI. After this needle switch, the skin changes resolved in 15 out of 20 patients. Among the five patients who did not respond to the needle change, the skin changes resolved in three patients by dexamethasone (0.5∼1 mg/day) added to CSCI. Conclusion: These findings suggest that both switching from a winged needle to a small plastic intravenous catheter and adding dexamethasone to a CSCI regimen are effective in the treatment of inflammatory skin changes caused by CSCI.

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The primary aim of this study was to collect the views of physicians and nurses in the regions where community-based palliative care intervention trial, the OPTIM-study, was performed. A content analysis of free comments of the questionnaire survey was conducted. Questionnaires were mailed to 1,763 physicians and 3,156 nurses after the intervention, and 706 and 2,236 responses were obtained, respectively. A content analysis identified 327 free comments from physicians and 737 from nurses. As favorable effects, the categories [Multidisciplinary teams and community networks were established] [Home-based care is widespread] [Medical knowledge and skills are acquired just as those involved in palliative care] emerged. The main effects of the community palliative care program included the establishment of multidisciplinary teams and community networks, development of home-based care, and increasing knowledge, skills, and awareness about palliative care.

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Most palliative care units in Japan allow patients to have their own pets visit them and also allow visits by therapy dogs, even though allowing animals into a hospital is not usually permitted. To determine which units allow patients to meet with their pets or have therapy dogs visit, questionnaires were sent 193 palliative care units, and the replies were obtained from the 149 units (77%). From the responses, it was determined that 135 units allowed patients to meet their pets on unit property, 36 units allowed patients to keep their pets with them, 121 units allowed patients to meet their pets in their hospital rooms, and 22 units adopted therapy dogs as animal-assisted therapies. Units established by religious organizations were more likely to allow patients to keep pets than non-religious organizations, and units established earlier more often allowed patients to meet up with their own pets than more recently established units. However, the use of animal therapy was equally likely in all units, regardless of religious affiliation or the age of the establishment. It is clear that being hospitable to patients' needs, and desires can be found in the newer palliative care units.

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Cancer patients in terminal phase often feel self-perceived burden to their family and medical staff. The self-perceived burden should be alleviated, though needed care has not been fully investigated. This study aimed to investigate the self-perceived burden of terminal cancer patients and needed care. Semi-structured interviews were conducted for twenty-eight bereaved family members of cancer patients. The results revealed, 1) cancer patients' self-perceived burdens; including eight categories such as “It is distressful to have other people take care of my excretory needs”, 2) cancer patients' self-perceived behaviors to cope with their emotional burdens; including 11 categories such as “Telling the family to give higher priority to their work and plans”, 3) families' feelings and coping behaviors; including 15 categories such as “I thought of the patient's withholding of requests as a consideration for me“, and 4) care required for the patients' self-perceived burden; including nine categories such as “Speaking naturally instead of emphasizing something in particular”. The usefulness of care should be discussed.

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Purpose: The Liverpool Care Pathway is a clinical path for the dying patient. In this study, a pilot study of a Japanese language version of the Liverpool Care Pathway Powered by Editorial Manager® and Preprint Manager® from Aries Systems Corporation (henceforth, “LCP”) was carried out in order to investigate the significance of using LCP and the possibility of its introduction. Method: 1. LCP was used on inpatients in the palliative care wards, and the status of the achieved care goal was evaluated. 2. A questionnaire survey regarding the usefulness of LCP was conducted on the nursing staff of the study facility. Results: The care goal indicated by LCP were achieved in 80% or more of the patients and families. The nursing staff members were asked to evaluate of LCP was evaluated the usefulness of LCP in confirming that the patient is in the dying phase, reviewing end-of-life care, continuous integrated care giving, and education for nurses with limited experience with end-of-life care. Conclusion: The high degree of achievement of the care goal in LCP shows concordance between LCP and end-of-life care at the study facility, and shows that it is possible for LCP to be introduced as an index of clinical pathway for end-of-life care giving. In addition, the nurses' evaluations imply the significance of LCP in reinforcement and education with regard to end-of-life care giving.

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The aim of this study is to collect the suggestions and recommendations of health care professionals involved in the regional palliative care program (OPTIM-study). A total of 101 multidisciplinary health care professionals who participated in the intervention program were interviewed, and 107 meaningful units were obtained from 89 valid interviews. The responses were categorized into “suggestions regardless of profession” (n=59), including “Participate in a multi-disciplinary conference to expand the network of people”, “Try to understand the situation of others”, “Seek support from others when you cannot solve the problem by yourself”, “Pursue all possibilities before giving up”, and “Do not try too hard”. As suggestions to those engaged in each profession, “Suggestions to community pharmacies” and “Suggestions to care managers” are frequently described. An examination of suggestions by the participants in the regional palliative care program could provide some insights to improve community palliative care.

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Purpose: The Palliative Care Education Program based on the Cancer Control Act has been held throughout Japan since 2008. The aim of this study is to identify changes attained through the program from the trainers' perspective. Method: The contents of the brain-storming sessions with the twelve trainers were qualitatively analyzed. Results: Six main categories of improvement were identified. These include: Reinforced cooperation; improved palliative care skills and knowledge; improved awareness of palliative care; improved understanding of the local palliative care resources; behavior modification of the participants; and development of in-hospital palliative care systems. Conclusion: Trainers recognized that holding the Palliative Care Education Program provides not only direct results such as greater knowledge and improved delivery of palliative care by physicians, but also indirect results such as enhanced cooperation and improved awareness of local palliative care resources.

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Objectives: The purpose of this study was to examine common experiences among patients and primary family caregivers as they transition to hospice and palliative care units (PCU), with focus on the perspectives of cancer patients and their primary family caregivers. Methods: We conducted semi-structured interviews using a questionnaire with a purposive sample of 5 terminal cancer patients and 9 primary family members of patients who were admitted to the PCU from November 2005 to December 2006. The questionnaires consisted of questions about the PCU, and semi-structured interviews inquired about perceptions of the PCU. We analyzed interview contents from 14 participants (mean age ±SD; patients, 77.2±4.0 years; family members, 53.7±14.6) by summarizing content analysis. The Aiwa Hospital Institutional Review Board approved the present study. Results: Content analysis identified common perceptions about the PCU. Perceptions prior to the transition were summarized into 2 categories for patients and 5 categories for families, including general impressions of the PCU, PCU environment and equipment, treatment, cost, and other patients. After being admitted to the PCU, perceptions were summarized into 3 categories for patients and 7 categories for families, including general impressions of the PCU, PCU environment and equipment, treatment, staff, cost, other patients, and religion. Conclusion: Identification of these themes from patient and family perspectives suggested that patients transitioned to hospice with no particular impressions about the PCU, while families perceived the PCU as both “a place to relax” and “a place where one only waits to die” before entering the PCU. These results may aid in designing interventions that consider patient and family needs and desires during the transition to the PCU.

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Purpose: Although case reports on the use of octreotide for malignant ascites are occasionally seen, it remains unclear whether or not octreotide is effective in such cases. The aim of this study was to clarify the utility of octreotide for malignant ascites. Methods: This study was a retrospective study based on a survey of medical records. The subjects were taken from among cancer patients at our hospital who were given octreotide between April 1, 2008 and October 31, 2011 with the aim of reducing gastrointestinal symptoms accompanying gastrointestinal obstruction. These subjects were patients who had malignant ascites during the time octreotide was used and whose ascites could be evaluated by computed tomography before and after octreotide was started. Evaluation of ascites was classified into five levels of obviously decreasing, slightly decreasing, no change, slightly increasing, and obviously increasing. Results: Forty-nine patients used octreotide during the same period. Seven of these 49 patients met the eligibility criteria. The level of ascites was not classified as obviously decreasing or slightly decreasing in any of the patients. One patient was classified as no change. The other six were all slightly increasing or obviously increasing. Conclusion: In this study octreotide was not shown to be usuful for malignant ascites.

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The purpose of the present study was to obtain the insights about the roles of specialized home care clinics and the “Doctor net” in community palliative care by investigating changes in the home death rates of cancer patients in a city where both specialized home care clinics and the Doctor net are available. A region palliative care intervention study was conducted, and data on the rate of cancer patients who died at home between 2007 and 2010 in the region were collected. The rate of cancer patients who died at home increased from 7.0% in 2007 to 13.0% in 2010. In 2007, 49% of the total number of people who died at home were patients of specialized home care clinics, and the rate increased to 13.0% in 2010. However, the number of cancer patients of other clinics who died at home did not decrease, from 63 in 2007 to 98 in 2009 and 77 in 2010. The functions of specialized home care clinics and the Doctor net adopted in general clinics were not exclusive to each other, and specialized home care clinics may improve palliative care implemented for cancer patients at home by participating in the Doctor net to provide general clinics with support.

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To explore the concept of “kao-no-mieru kankei (face-to-face relationships)” and effects on community care networks, questionnaire and interview surveys were conducted involving 207 and 5 health care professionals, respectively. The item “face-to-face relationships” were significantly correlated with “I know his/her name, face, and way of thinking” “I understand the principles and current status of the facility” “I know his/her characteristics and how to deal with them”, and “I know what each person does” (p>0.7). An interview survey showed that “face-to-face relationships” consisted of “know the name and face” “know what s/he is like” and “trust in each other”. As effects of “face-to-face relationships” on community care networks, the following items were extracted: “It facilitates easy communication” “It provides me with information on who is responsible for which problem” “It facilitates smooth communication by changing my approach” “It makes me effective at work” “It gives me a sense of intimacy”, and “it gives me the responsibility”. Thus, preliminary findings of the concept and effects of “face-to-face relationships” were obtained.

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Liverpool Care Pathway (LCP) Japanese version was implemented to electronic medical chart (FUJITSU HOPE/EGMAIN-FX®). The processes were needed as follows; preparation of each templates (criteria for use of the LCP/initial assessment, ongoing assessment, and care after death), preparation of pathway/regimen, incorporation of the templates to the pathway and approval in our hospital clinical pathway committee. One problem we encountered was whether to choose an Excel or a template format for each assessment sheet, and the template format was selected as it presented us with a higher degree of convenience, since each field can be expanded into a table on the screen without scrolling and there is little limitation in the letters of the valiance records that can be used in the template format. The complexity of the three records, “the pathway”, “SOAP & focus” for recording opioid use, and “the progress sheet” for recording vital signs, in addition to the inability to expand enough to capture the same field and show changes in the daily pathway over time through night and day work shifts remain a challenge and need to be improved in the future.

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This study was conducted to identify the needs of patients and their families based on surveys involving patients and bereaved families, and describe the process of producing a survey-based leaflet for health care professionals. Questionnaire surveys were conducted on 550 advanced cancer patients and 632 bereaved families in Hamamatsu, and 337 and 432 responses were collected. Opinions and requests regarding cancer treatment and palliative care were analyzed, and 378 meaning units were collapsed into six categories of requests to health professionals: “Share patient and family feelings and support decisions”; “Allow the patient to stay where he/she wants”; “Relieve physical discomfort as much as possible”; “Support to complete what family members want for the patient not to regret”; “Help patient and family have hope”, and; “Reduce concerns about opioids”. A leaflet for health care professionals about what they should take into the considerations was created based on patient and family surveys.

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A man in his 60s, who was diagnosed as having postoperative recurrent gastric cancer with lymph node and spinal metastases, was admitted to our palliative care unit (PCU). He was unable to receive further aggressive chemotherapy for cancer because of bilateral hydronephrosis and chronic renal failure. He had chronic urethral infection and hence required continuous antibiotic administration. Although his infection was well controlled with antibiotics, his oral intake gradually declined. Seventeen days after admission, he developed systemic hemorrhage, including hematuria and oral bleeding. Coagulation tests revealed that the patient had markedly prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) but no thrombocytopenia, fibrinogen consumption, or increased fibrin/fibrinogen degradation products (FDP) level. Serum level of protein induced by vitamin K absence or antagonist II (PIVKA-II) was markedly high, and vitamin K level was below the lower limit of the reference range. After he was administered intravenous vitamin K, his symptoms markedly improved. Many patients with advanced cancers tend to have malnutrition, anorexia, and chronic infection that require antibiotic administration. Prophylactic administration of vitamin K might be sometimes necessary for preventing catastrophic hemorrhage.

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This is a report on a case of delirium due to a small amount of ketamine with voriconazole. A 58 year old male was treated for multiple myeloma and hip pain due to an extramedullary tumor following the administration of oxycodone, and voriconazole was administrated for his suspected mycotic pneumonia. His pain was refractory, so we started the administration of a small dose of ketamine (4 mg/hr) for analgesia, added to oxycodone. About 30 hours later, the delirium appeared but he complained of worsening hip pain, so we added 2 mg of ketamine rapidly. Immediately after the additional administration of ketamine, his delirium became more serious. We think the reason why a small amount of ketamine induced delirium is an interaction of ketamine and voriconazole. Ketamine is metabolized to norketamine, which is thought to be more harmless than ketamine, by cytochrome P 450 (CYP) (a part of by CYP3A4) and voriconazole is an inhibitor of CYP3A4. In cases of patients treated with voriconazole, ketamine should be more carefully administrated.

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Purpose: To report a case of successful treatment of pruritus with mirtazapine in a patient with advanced cancer. Case summary: A male patient in his seventies with advanced malignant lymphoma had pruritus. The patient began to have pruritus within a few days after starting anti-epilepsy treatment. Oral mirtazapine was administered at a dose of 15 mg/day. Within 2 days, the patient showed partial improvement of his symptoms. After 7 days of mirtazapine therapy, the pruritus significantly improved. While the patient was taking a dose of 15 mg/day, he remained asymptomatic. Conclusion: There are only a few reports (none in Japan) showing the effectiveness of mirtazapine against pruritus in patients with advanced cancer. Although the mechanism of the pruritus-relieving effect of mirtazapine is not fully understood, this case report indicates that mirtazapine may help in the treatment of patients suffering from intractable pruritus.

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Introduction: Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) and the previous reports show that may reduce nausea by inhibition of the serotonin 5-HT3receptor. Case report: A 38-year-old woman with advanced renal cancer with distant metastases was administered by sunitinib and oxycodone. Refractory nausea and vomiting developed during the course and mirtazapine at a daily dose of 1.875 mg was begun. The patient's nausea improved during the next day, and furthermore, by increasing the daily dose to 3.75 mg, vomiting was also improved on the third day. The therapy could be continued without withdrawal of sunitinib and oxycodone due to digestive symptoms. Although somnolence might be induced at a daily dose of 15 mg, the present low-dose mirtazapine could improve digestive symptoms without somnolence. Conclusion: We conclude that low-dose mirtazapine is one effective option for refractory nausea and vomiting during administration of sunitinib and oxycodone.

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We report a patient with gingival metastasis of lung cancer in whom the use of sedatives was successfully avoided by employing holistic care approaches. A 64-year-old man had been receiving chemotherapy with the diagnosis of advanced lung cancer. Eighteen months later, a rapidly growing gingival metastasis was observed. Arterial embolization was performed, but it failed to control the bleeding. No active treatment was performed, and he was subsequently transferred to our hospital. He desired death, with markedly pessimistic views, and wished to undergo deep and continuous palliative sedation (DCPS) due to severe total pain (particularly psychological and spiritual) from the beginning. However, he died peacefully before receiving DCPS. We present a literature review of gingival metastasis from lung cancer, as well as our assessment and palliative care for the total pain of this patient.

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We report a case in which feelings of abdominal distension and discomfort of the abdominal wall caused by malignant ascites were relieved by ultrasound-guided rectus sheath block. Case report: A 59-year-old man developed gastric cancer with malignant ascites and experienced feelings of abdominal distension, but no nausea, dyspnea, poor mobility, or limb edema. Symptom control was inadequate with diuretic therapy and abdominal paracentesis. Feelings of distension improved temporarily with ultrasound-guided rectus sheath block. A percutaneous catheter was then used to administer an infusion of 0.25% ropivacaine triweekly until his death 20 days later. Conclusion: Feelings of abdominal distension is one of various symptoms of severe ascites and is difficult to manage. Ultrasound-guided rectus sheath block can be used to relieve this symptom on a case-by-case basis.

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To enhance the quality of life for cancer patients, it is required that choice and useage of appropriate medications for their symptoms, as well as providing education for patients and their family members be provided. The purpose of this article was to examine the effectiveness of cancer pain management education through a literature review. From a search of key medical databases, potential articles regarding cancer pain management were retrieved. From a thorough literatures review, we found six important trends: (1) discordance of cancer patients and their families pain reports; (2) family perception regarding cancer pain; (3) family's concerns about cancer pain management; (4) family member's role in cancer pain management; (5) helpful resources about cancer pain management and (6) educational programs for cancer patient's family. Further research regarding educational programs for family members is required for improving cancer pain management.

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