Purpose:We evaluated whether a combination of skin barrier and skin sealant can reduce the amount of stratum comeum removed upon peeling off the skin barrier, and whether skin barrier function is maintained.
Methods:Skin was prepared with tape stripping using an adhesive on the lower abdomen of eight volunteers. Two types of sealant were applied to the skin, and a skin barrier was placed over the region. The skin barrier was covered by a film dressing, and 48 hours after application, the skin barrier was peeled off and the amount of skin remaining was measured. The skin barrier and skin sealant were applied to the region again, and the procedure repeated after 4 and 6 days. Peel force, cell quantification with staining, and transepidermal water loss (TEWL) were measured every second day.
Results:The combination of skin barrier and skin sealant significantly reduced peel force, amount of stratum comeum removed, and TEWL (p<0.O1). Sealant B in particular reduced the amount of stratum corneum removed and TEWL.
Conclusion:These results suggest that use of a sealant under the skin barrier can reduce peel irritation and maintain skin barrier function.
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