Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

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Short Oral Presentations

AHR LIGAND ACTIVITY OF ENVIRONMENTAL CONTAMINANTS AND THE EFFECT OF METABOLIC MODIFICATION

Seiji Shinohara, Shigeyuki Kitamura, Nariaki Fujimoto, Kazumi Sugihara ...

Session ID: 29C09-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.193.1

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CHARACTERIZATION OF THE RAT CARBOXYLESTERASE 2 (CES2) ISOZYME INDUCED BY DRUGS AND THEIR MOLECULAR MECHANISMS

Yuko Nagahara, Tomomi Furihata, Ayako Fujii, Tetsuo Satoh, Kan Chiba, ...

Session ID: 29C10-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_193_2

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A HERBICIDE PYRIBUTICARB IS MORE POTENT INDUCER OF CYP3A4 EXPRESSION INTERACTING WITH PREGNANE X RECEPTOR THAN RIFAMPICIN

Tsutomu Matsubara, Takayoshi Toriyabe, Kouichi Yoshinari, Kiyoshi Naga ...

Session ID: 29C10-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.194.1

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INDUCTION OF CYP3A BY DEXAMETHASONE IN RAT SMALL INTESTINE AND LIVER

Masashi Saitoh, Mayu Ohsawa, Shuhei Takano, Yasuyuki Tsuda, Tomoo Itoh

Session ID: 29C10-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_194_2

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HEPATIC CYP3A EXPRESSION IS ATTENUATED IN OBESE MICE FED A HIGH-FAT DIET

Kouichi Yoshinari, Mika Sugawara, Shunsuke Takagi, Junko Sugatani, Mas ...

Session ID: 29C10-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.195.1

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EFFECTS OF MUTATIONS IN LIGAND BINDING DOMAIN OF HUMAN PXR ON TRANSCRIPTIONAL ACTIVITY AND INTERACTION WITH COREGULATORS

Masaki Mikamoto, Kaoru Kobayashi, Saeko Yamagami, Kosuke Saito, Kan Ch ...

Session ID: 29C10-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_195_2

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IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE PROMOTER REGION OF TWO CARBOXYLESTERASE 1 GENES AND ALTERATION OF IMIDAPRIL RESPONSIVENESS BY TRANSCRIPTION BINDING SITE

Mika Yohimura, Tomomi Kimura, Eichi Geshi, Takashi Katagiri, Masakiyo ...

Session ID: 29C11-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.196.1

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ANTI-TUMOR PROTEIN P53 ACTIVATES THE TRANSCRIPTION OF THE HUMAN CYP1A1 GENE

Norihito Shibahara, Shunsuke Iwano, Tetsuya Kamataki

Session ID: 29C11-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_196_2

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Developmental changes of aldehyde oxidase activity of Japanese children, including three monozygotic twins

Yoshitaka Tayama, Katsushi Miyake, Kazumi Sugihara, Shigeyuki Kitamura ...

Session ID: 29C11-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.197.1

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EXPRESSION OF CYTOCHROME P450 AND NUCLEAR RECEPTORS IN CULTURED RAT SMALL HEPATOCYTES AFTER LONG-TERM CRYOPRESERVATION

Hidekazu Ooe, Junko Kon, Yoshiyasu Ozone, Shin-ichi Ninomiya, Toshihir ...

Session ID: 29C11-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_197_2

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USEFULNESS OF MICRODIALYSIS METHOD TO DETERMINE FREE DRUG CONCENTRATION IN EPITHELIAL LINING FLUID OF RATS

Makoto Aoki, Maki Iguchi, Hiroyuki Hayashi, Shigeki Shibasaki, Masahir ...

Session ID: 29D09-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.198.1

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THE BINDING SITE AT DOMAIN III OF DOG ALBUMIN HAS A BINDING TOPOLOGY THAT IS VERY SIMILAR TO SITE II OF HUMAN ALBUMIN

Ken-ichi Kaneko, Hikaru Fukuda, Chuang Tuan Giam Victor, Keishi Yamasa ...

Session ID: 29D09-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_198_2

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STRUCTURAL CHANGES AFFECT PHARMACOKINETICS OF HUMAN SERUM ALBUMIN

Mikako Hiraike, Yasunori Iwao, Ulrich Kragh-Hansen, Keiichi Kawai, Tor ...

Session ID: 29D09-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.199.1

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IN VITRO ALTERATION ON THE CHIRAL INVERSION OF IBUPROFEN IN ADJUVANT-INDUCED ARTHRITIS RAT HEPATOCYTES

Satoshi Uno, Misato Uraki, Atsushi Kawase, Masahiro Iwaki

Session ID: 29D10-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_199_2

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FUNCTIONAL ANALYSIS OF NOVEL FLAVIN CONTAINING MONOOXYGENASE 3 VARIANTS, THR201LYS AND MET260VAL, FOUND IN A JAPANESE POPULATION

Makiko Shimizu, Norie Murayama, Hiroshi Yamazaki

Session ID: 29D10-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.200.1

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IN VITRO GLUCURONIDATION OF ANTIALLERGIC DRUG, TRANILAST, IN HUMAN

Miki Katoh, Tomohito Matsui, Miki Nakajima, Tsuyoshi Yokoi

Session ID: 29D10-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_200_2

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THE ACTIVE METABOLITE (DPr-P-4(N→O)) MAY CONTRIBUTE TO THE BLADDER SELECTIVITY OF PROPIVERINE HYDROCHLORIDE USED TO TREAT PATIENTS WITH OVERACTIVE BLADDER

Luvsandorj Oyunzul, Tomomi Oki, Shinya Uchida, Yukiko Takagi, Ken-ichi ...

Session ID: 29D10-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.201.1

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INTERACTION OF PRAZOSIN AND METOPROLOL IN SPONTANEOUSLY HYPERTENSIVE RATS

-PK-PD ASSESSMENT BASED ON BLOOD PRESSURE REGULATORY SYSTEM -

Shin-ya Naruhashi, Makoto Miyazaki, Shinji Sato, Ken-ichi Watanabe, Ka ...

Session ID: 29D10-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_201_2

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COMPARISON OF PHARMACODYNAMICS BETWEEN CARVEDILOL AND METOPROLOL IN RATS WITH ISOPROTERENOL-INDUCED HEART FAILURE

Kazuhiko Asari, Masahiro Kaneko, Shingo Shoji, Shinji Murakami, Kazuhi ...

Session ID: 29D11-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.202.1

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RELATIONSHIP BETWEEN THE ANTINOCICEPTIVE EFFECT OF ST JOHN'S WORT AND PLASMA AND BRAIN CONCENTRATION OF HYPERFORIN

Keita Hirai, Shinya Uchida, Yuko Taki, Yukiko Shinme, Junko Hanato, Hi ...

Session ID: 29D11-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_202_2

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MOLECULAR CLONING AND FUNCTIONAL ANALYSES OF OATP-A AND OATP-C FROM BEAGLE DOG LIVER

Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama

Session ID: 29C13-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.203.1

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FUNCTIONAL CHARACTERIZATION OF THE ORGANIC SOLUTE TRANSPORTER ALPHA/BETA (OSTα/β)

Etsuro Watanabe, Hiroyuki Kusuhara, Yuichi Sugiyama

Session ID: 29C13-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_203_2

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FUNCTIONAL CHARACTERIZATON, TISSUE DISTRIBUTION AND IMMUNOLOCALIZATION OF RAT H⁺/ORGANIC CATION ANTIPORTER MATE1

Masahiro Tsuda, Tomohiro Terada, Jun-ichi Asaka, Satohiro Masuda, Tosh ...

Session ID: 29C13-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.204.1

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ROLE OF BILE ACID ABSORPTION IN THE REGULATION OF HEPATIC BILE ACID LEVELS

Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Frank J. Gonzalez, Y ...

Session ID: 29C14-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_204_2

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PHENOTYPE ANALYSIS OF ORGANIC CATION/CARNITINE TRANSPORTER OCTN1 (SLC22A4) GENE KNOCKOUT MICE

Yoshiyuki Kubo, Daisuke Iwata, Yukio Kato, Kazushi Sugihara, Masahide ...

Session ID: 29C14-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.205.1

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DRUG DISPOSITION IN ORGANIC CATION/CARNITINE TRANSPORTER OCTN1 (SLC22A4) GENE KNOCKOUT MICE

Daisuke Iwata, Yoshiyuki Kubo, Tadakatsu Nakamura, Kimihiro Ito, Yukio ...

Session ID: 29C14-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_205_2

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DOWN-REGULATION OF RENAL ORGANIC ANION TRANSPORTERS rOAT1 AND rOAT3 BY ISCHEMIA/REPERFUSION OF RAT KIDNEY

Takanobu Matsuzaki, Kanako Yoshitome, Takafumi Morisaki, Hiroshi Watan ...

Session ID: 29C14-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.206.1

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CHOLESTEROL-DEPENDENT EXPRESSION OF NIEMANN-PICK C1 LIKE 1

Yuki Iwayanagi, Tappei Takada, Hiroshi Suzuki

Session ID: 29C14-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_206_2

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INVOLVEMENT OF MOUSE OATP1A4 IN THE UPTAKE OF ORGANIC ANIONS ACROSS THE BLOOD-BRAIN BARRIER

Atsushi Ose, Hiroyuki Kusuhara, Chihiro Endo, Yuichi Sugiyama

Session ID: 29C15-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.207.1

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INVOLVEMENT OF OCTN2 IN TISSUE DISTRIBUTION OF ORGANIC CATIONS

Tadakatsu Nakamura, Yoshiyuki Kubo, Yukio Kato, Akira Tsuji

Session ID: 29C15-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_207_2

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CHARACTERIZATION OF CELLULAR UPTAKE OF THE BASIC PEPTIDE N-WASP181-200 THAT INHIBITS RENAL ACCUMULATION OF GENTAMICIN

Masaki Saito, Junya Nagai, Ryoko Yumoto, Mikihisa Takano

Session ID: 29C15-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.208.1

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FUNCTIONAL CHARACTERIZATION OF THE CARRIER INVOLVED IN METHOTREXATE UPTAKE IN CACO-2 CELLS

Mai Hatakeyama, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa

Session ID: 29C15-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_208_2

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INTESTINAL ABSORPTION OF METHYLPREDONISOLONE BY P-GLYCOPROTEIN AND ITS REGULATION BY ESSENTIAL FATTY ACIDS IN INFLAMMATORY BOWEL DISEASES

Satoshi Wakabayashi, Mikio Tomita, Masahiro Hayashi

Session ID: 29C15-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.209.1

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FUNCTIONAL CHARACTERISTICS OF THE CARRIER-MEDIATED FOLATE TRANSPORT SYSTEM IN THE RAT SMALL INTESTINE

Sayaka Ueda, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa

Session ID: 29C16-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_209_2

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EFFECT OF URSODEOXYCHOLATE ON THE FUNCTION OF INTESTINAL EFFLUX TRANSPORTERS AND CYP3A IN RATS

Shota Hamada, Ryoko Yumoto, Keiko Yamakawa, Junya Nagai, Mikihisa Taka ...

Session ID: 29C16-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.210.1

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FUNCTIONAL CHARACTERIZATION OF THE CARRIER INVOLVED IN CLONIDINE UPTAKE BY HACAT CELLS

Makiko Sugimoto, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa

Session ID: 29C16-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_210_2

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FUNCTIONAL CHARACTERISTICS OF H⁺-DEPENDENT NICOTINATE TRANSPORT IN RAT PRIMARY CULTURED ASTROCYTES

Yasuhiro Matsumoto, Ayumi Shimada, Hidemasa Katsumi, Akira Yamamoto, T ...

Session ID: 29C16-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.211.1

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THE CHARACTERISTICS OF mRNA EXPRESSION OF Abcc2, Abcg2 AND Mdr1a AND THE EFFLUX ACTIVITY OF PRAVASTATIN ACROSS INTESTINE IN LONG-EVANS CINNAMON RAT, AN ANIMAL MODEL FOR WILSON'S DISEASE

Makoto Chiba, Shirou Itagaki, Masaki Kobayashi, Takeshi Hirano, Ken Is ...

Session ID: 29C16-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_211_2

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A NOVEL NUCLEOSIDE TRANSPORT-DEFICIENT CELL LINE ISOLATED FROM MADIN-DARBY CANINE KIDNEY CELLS IS A VALUABLE SYSTEM FOR THE CHARACTERIZATION OF THE NUCLEOSIDE TRANSPORTERS

Misato Hashizume, Tomomi Furihata, Kan Chiba

Session ID: 29C17-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.212.1

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FUNCTIONAL CHARACTERIZATION OF L-CARNITINE TRANSPORT SYSTEM IN MOUSE PRIMARY CULTURED NEURONS: INVOLVEMENT OF A Na+/ClCOUPLED GABA TRANSPORTER GAT1

Shiori Fujiwara, Ayumi Shimada, Hidemasa Katsumi, Akira Yamamoto, Taku ...

Session ID: 29C17-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_212_2

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POLYCYCLIC AROMATIC HYDROCARBONS INCREASE PHOSPHOLIPID TRANSFER PROTEIN GENE EXPRESSION BY AN ARYL HYDROCARBON RECEPTOR-DEPENDENT MECHANISM

Hideki Marubashi, Norihito Shibahara, Shunsuke Iwano, Tetsuya Kamataki

Session ID: 29C17-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.213.1

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EFFECT OF P-GLYCOPROTEIN ON INTESTINAL ABSORPTION OF ORALLY ADMINISTERED DRUGS

Katsuhiro Igeta, Takuo Washio, Norio Suzuki, Hiroshi Kikuchi, Kenichi ...

Session ID: 29C17-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_213_2

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AMPICILLIN PRODRUGS INTERACT WITH P-GLYCOPROTEIN: IN VITRO STUDY ON SUCCESSFUL PRODRUGS USING CACO-2 CELLS

Sachie Tanaami, Sayaka Sakaguchi, Takashi Mizuma, Masahiro Hayashi

Session ID: 29C17-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.214.1

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CHANGES OF EXCRETORY PATHWAY OF DRUGS BY LIVER DYSFUNCTION

Hirotoshi Okumura, Miki Katoh, Keiichi Minami, Miki Nakajima, Tsuyoshi ...

Session ID: 29C18-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_214_2

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EFFECT OF P-GLYCOPROTEIN ON ORAL DRUG ABSORPTION

ABSORPTION -QUANTITATIVE EVALUATION OF IN VIVO INTESTINAL PERMEABILITY OF P-GLYCOPROTEIN SUBSTRATE DRUGS-

Yoshiyuki Shirasaka, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma, To ...

Session ID: 29D13-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.215.1

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PREDICTION OF INTESTINAL ENZYME MEDIATED DRUG-DRUG INTERACTION AND NONLINEAR INTESTINAL FIRST-PASS METABOLISM

Tatsuhiko Tachibana, Motohiro Kato, Tomoko Watanabe, Tetsuya Mitsui, Y ...

Session ID: 29D13-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_215_2

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QUANTITATIVE ANALYSIS OF THE FIRST-PASS METABOLISM IN THE SMALL INTESTINE AFTER ORAL DRUG ADMINISTRATION

Toru Izuchi, Makoto Kataoka, Shinji Sakuma, Masayuki Takahashi, Takuo ...

Session ID: 29D13-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.216.1

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IMPROVEMENT OF ORAL ABSORPTION BEHAVIOR OF POORLY WATER-SOLUBLE DRUG USING SMEDDS: PHARMACOKINETIC ANALYSIS AND PREDICTION BASED ON GITA MODEL(II)

Yoshitsugu Fujioka, Yukiko Metsugi, Takanori Hironaka, Motoki Ochi, Ke ...

Session ID: 29D14-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_216_2

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PHARMACOKINETIC ANALYSIS OF GASTRO-INTESTINAL TRANSIT AND ABSORPTION PROFILES IN PATIENTS BEFORE AND AFTER GASTROSTOMY

Yukiko Metsugi, Yasuko Fujie, Yoshitsugu Fujioka, Ryuichi Nishii, Hide ...

Session ID: 29D14-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.217.1

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A COMPREHENSIVE ANALYSIS ON THE SPECIES DIFFERENCE IN OF ORAL DRUG ABSORPTION IN DOGS, MONKEYS AND HUMANS

Takuo Washio, Norio Suzuki, Katsuhiro Igeta, Masayuki Takahashi, Hiros ...

Session ID: 29D14-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_217_2

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