Japanese Journal of Stroke
Online ISSN : 1883-1923
Print ISSN : 0912-0726
ISSN-L : 0912-0726
Volume 17, Issue 6
Displaying 1-7 of 7 articles from this issue
  • Akiro Terashi
    1995 Volume 17 Issue 6 Pages 481-488
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
    With the advent of new neuroimaging techniques, it is now possible to validly show white-matter lesions in cerebrovascular disease. However, their pathogenesis and clinical significance remain elusive. Therefore we investigated periventricular hyperintensity (PVH) in white matter lesions in patients with cerebrovascular disease and obtained the following results :
    1. Aging, hypertension and ischemia were risk factors for PVH production.
    2. In multiple infarct cases without dementia, cases with PVH had low cerebral blood flow in the frontal cortex, especially in the frontal cingulate gryus in addition to the cortical white-matter.
    3. In cases of severe ischemic white-matter lesions, the activity of cortical areas related to auditory cognition was shown to be decreased in a PET activation study.
    4. An apoptoic mechanism was indicated in frontal deep white-matter legions in cases with multiple infarction dementia.
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  • Seiji Ogawa
    1995 Volume 17 Issue 6 Pages 489-496
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
    Functional MRI of the brain is briefly reviewed. The two methods used in fMRI to capture hemodynamic changes induced by brain activation are described. One is to measure regional CBF change by the inflow signal for a single slice image and the other is to acquire BOLD images where the image contrast is generated by the magnetic susceptibility of red cells containing paramagnetic deoxyhemoglobin. With these types of measurements, many images are taken rapidly in time sequence at a constant image acquisition mode and thus one can follow the brain activation in real time. Various early applications of fMRI to sensory stimulations, motor responses and some of cognitive functions are described and the potentials of fMRI are discussed. The feasibility of fMRI to use in stroke field is high and the merit of the method is expected to be extremely useful in the field.
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  • Studies in a Gerbil Model of Induced Tolerance
    Thaddeus S. Nowak Jr., Hiroshi Abe
    1995 Volume 17 Issue 6 Pages 497-500
    Published: December 25, 1995
    Released on J-STAGE: January 25, 2010
    JOURNAL FREE ACCESS
    Brief ischemic insults protect against injury following subsequent longer and otherwise damaging periods of ischemia, although such protective effects have usually been quite variable. Selective changes in gene expression are considered good candidates for mediators of the tolerance phenomenon, and the stress protein, hsp72, has received considerable attention in this regard. In recent experiments we have monitored the interval of ischemic depolarization following brief periods of occlusion and have identified depolarization thresholds for tolerance, for injury and for various changes in gene expression. While hsp72 is clearly inducible after moderate insults that do not injure neurons, our results indicate that neuronal protection can be achieved by even milder insults that do not appreciably induce hsp72, but that do induce immediate-early genes of the Fos and Jun families with lower depolarization thresholds. In addition, these studies provide the basis for a reproducible model in which mechanisms of tolerance can be further studied.
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  • [in Japanese], [in Japanese], Masayasu Matsumoto, Yasuo Katayama, Tats ...
    1995 Volume 17 Issue 6 Pages 501-540
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], Kanehiro Hasuo, Koichi Uc ...
    1995 Volume 17 Issue 6 Pages 541-563
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], Setsuro Ibayashi, Norio Tanahashi, Shini ...
    1995 Volume 17 Issue 6 Pages 564-599
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
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  • 1995 Volume 17 Issue 6 Pages 600-701
    Published: December 25, 1995
    Released on J-STAGE: September 16, 2009
    JOURNAL FREE ACCESS
    Download PDF (24093K)
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