Serum samples were collected from a total of 248 horses in Hokkaido during a period of 1965-1971 and examined for hemagglutination-inhibiting (HI) and/or complement-fixing (CF) V and S antibodies against 4 strains of equine and human influenza virus; that is A/Equi-1/Prague/56, A/Equi-2/Miami/63, A/Aichi/2/68 (Hong Kong type), and A/Kumamoto/1/67 (A2 type). The serum samples from 168 horses native to Hokkaido were all negative (<1:8) for each of the virus strains in HI tests. Of them, 129 samples were also proved to be negative (<1:4) for the CF test with equine and Hong Kong virus
It was confirmed that there had been no epizootic of influenza among horses in Hokkaido before 1970. In contrast, of 80 horses imported before 1970, 48 (60.0%) had HI antibody against Equi-1, 23 (28.7%) against Equi-2, 14 (21.2%) against Hong Kong virus, and none against A2 virus. When examined by the CF-V test, 42.6% of the horses had antibody against Equi-1, 42.9% against Equi-2, and 9.8% against Hong kong virus. Besides, 63 sera were all negative for the CF-S test. The presence of antibody against Hong Kong virus in the imported horses suggested that this antibody might have been produced by infection (including vaccination) with antigenically related Equi-2 virus. Epizootiological analyses were carried out to clarify the relationship between the history and the presence of cserum antibody against equine influenza in the individual imported horses.
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