Advances in Animal Cardiology
Online ISSN : 1883-5260
Print ISSN : 0910-6537
ISSN-L : 0910-6537
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Volume 43, Issue 1
Displaying 1-3 of 3 articles from this issue
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ORIGINAL
  • The Effects of Subcutaneous ANP Administration in Normal Canine
    Nobuyuki KANNO, Kazushi ASANO, Kenji TESHIMA, Kazuya EDAMURA, Shigeo T ...
    2010 Volume 43 Issue 1 Pages 1-6
    Published: 2010
    Released on J-STAGE: March 18, 2011
    DOIhttps://doi.org/10.11276/jsvc.43.1
    JOURNAL FREE ACCESS
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    The objective of our investigation was to evaluate the effectiveness of subcutaneous atrial natriuretic peptide (ANP) administration in normal dogs. We administrated subcutaneously recombinant ANP (25 μg/kg). Plasma ANP concentration rapidly increased and peak concentration of 591.5±143.0 pg/ml reached at 5 min after subcutaneous ANP administration. Area under the blood concentration time curve was 27,874 min·pg/ml and elimination half time was 18.9±3.7 min. Systolic blood pressure was decreased and urine volume was increased. However, electrolyte excretion was not significant change. Our results suggest that subcutaneous ANP administration had biological effects in normal dogs.
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