動物の循環器
Online ISSN : 1883-5260
Print ISSN : 0910-6537
ISSN-L : 0910-6537
49 巻, 1 号
選択された号の論文の7件中1~7を表示しています
原著
  • 華園 究, 福本 真也, 小川 雄基, 吉田 智彦, 吉田 慧, 岩野 英知, 宮庄 拓, 打出 毅
    2016 年 49 巻 1 号 p. 1-9
    発行日: 2016/06/15
    公開日: 2016/07/07
    ジャーナル フリー
    三尖弁逆流を認める僧帽弁疾患の犬の血清big endothelin-1 (big ET-1)濃度を測定し,肺高血圧症のバイオマーカーとしての有用性を検討した。big ET-1はELISA法を用いて,13頭の三尖弁逆流を有す僧帽弁疾患の犬を対象に測定された。推定収縮期肺動脈圧(SPAP),右室長軸径(RVL),右室短軸径(RVS),右房長軸径(RAL),右房短軸径(RAS)および三尖弁拡張早期波血流速度/三尖弁輪拡張早期速度比(TVE/E′)は血清big ET-1濃度が16 pg/ml未満の群と比較して16 pg/ml以上の群で有意に高値を認めた。さらにbig ET-1はSPAP, RAL, RAS, RVL,およびRVSに有意な正の相関が認められた。結論としてbig ET-1は肺高血圧症を有する僧帽弁疾患の犬で上昇することが示され,肺高血圧症の臨床的重症度の指標となる可能性を有していると考えられた。
  • Hiroki YOSHIMATSU, Hirotaka MATSUMOTO, Masanari MINAMOTO, Ryohei SUZUK ...
    2016 年 49 巻 1 号 p. 11-16
    発行日: 2016/06/15
    公開日: 2016/07/07
    ジャーナル フリー
    Fatty acids are a major source of energy in the normal myocardium and are taken up passively from the bloodstream. However, with heart failure, the use of fatty acids decreases in the myocardium. Therefore, serum fatty acid concentrations in dogs with mitral insufficiency (MI) might differ from those in normal dogs. The present study was designed to determine the serum fatty acid compositions in dogs with different severities of MI according to the classification proposed by the International Small Animal Cardiac Heart Council (ISACHC) and to elucidate the relationships between the determined compositions and echocardiographic parameters. In total, 30 dogs with MI were divided into 3 groups (I, II, and III) according to the ISACHC classification of MI severity. The healthy group consisted of 12 dogs matched with the MI groups for age and body weight. The serum concentrations of 13 fatty acids were measured by gas chromatography. The levels of linoleic acid (LA), docosatetraenoic acid (DTA), and arachidonic acid (AA) in group I were significantly lower than those in the healthy group (p<0.05). The levels of eicosapentaenoic acid (EPA) and AA in group II were significantly lower than those in the healthy group (p<0.05). The level of EPA in group III was significantly lower than that in the healthy group (p<0.05). In addition, the ratio of EPA to AA levels (EPA/AA ratio) in group III was significantly lower than that in the healthy group (p<0.05). With regard to the relationships between fatty acid concentrations in all MI groups (I through III) and echocardiographic parameters, the levels of AA and DTA showed a significant positive correlation with the ratio of left ventricular end-diastolic internal diameter to aortic diameter (LVIDd/Ao ratio) (AA, r=0.396 and p=0.048; DTA, r=0.426 and p=0.027). In addition, the docosapentaenoic acid (DPA) level correlated negatively with fractional shortening (r=-0.437 and p=0.023). Furthermore, the EPA/AA ratio correlated negatively with the ratio of left atrial to aortic diameters (r=-0.383 and p=0.048). The fatty acid concentrations and ratios in the dogs with 3 types of MI according to the ISACHC classification differed from those in healthy dogs. Some of these concentrations and ratios correlated with echocardiographic parameters.
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