巻号一覧
5 巻, 1 号
選択された号の論文の7件中1～7を表示しています
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Sentaro TAKAHASHI, Osamu MATSUOKA1980 年 5 巻 1 号 p. 1-9
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーAge and sex differences of carbon clearance from the peripheral blood of the rat were investigated. The clearance of carbon was more rapid in the young rats than in the old. Sex difference was significant in the rats of 10 and 14 weeks old, but not significant in the rats of 3 weeks old. Liver blood flow, extraction rate of carbon by the liver and whole circulating blood volume may be the factors involved in the sex and age differences of the blood clearance of carbon.抄録全体を表示PDF形式でダウンロード (739K) -
Kazumasa YASUDA, Goro NOZAWA, Tomoko GOTO, Norihiro SASAKI, Sumiko ISH ...1980 年 5 巻 1 号 p. 11-21
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーAllergic contact dermatitis occurred with 2, 4-toluene diisocyanate (TDI) in BALB/c mice. The results were obtained by the measurement of the ear thickness after challenged to the ear with 1% TDI in olive oil in mice previously sensitized with 5% TDI. The ear swelling rate at 48 hr postchallenge in sensitized mice was more than twice of that in unsensitized mice. In BALB/c-nu/nu (nude) mice, delayed type hypersensitivity could not be induced even when a 30% TDI solution was applied. These results suggest that T cells may play an essential role in contact sensitivity to TDI in BALB/c mice.抄録全体を表示PDF形式でダウンロード (1294K) -
Yasuhide TONOGAI, Yoshio ITO, Masahiro IWAIDA, Masatomo TATI, Youki OS ...1980 年 5 巻 1 号 p. 23-33
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーReason of acute toxicity to fish caused by coal-tar dyes and their industrial effluents were studied from the three points of view. 1) Partition coefficient (n-octanol/water) was determined on several coal-tar dyes, and it was found that the larger the ratio was, the stronger was toxicity to fish. 2) As a result of determination about existent form of xanthene dyes under photo-irradiation, it was clarified that dyes in solution were in the form of excited triplet state and halogen in dye molecule was liberated in free form. 3) When coal-tar dyes were treated with sodium hypochlorite, harmful chloroform was detected from dye solution. Chloroform and its homologous compounds showed the low TLm value and had the serious effect on fish.抄録全体を表示PDF形式でダウンロード (721K) -
Masakatsu SAKATA, Masanobu HAGA1980 年 5 巻 1 号 p. 35-43
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーA method for the determining the amount of carbon monoxide (CO) in blood is described. CO bound to hemoglobin is released with potassium ferricyanide into a known volume of head space of a disposable syringe. Vapor in the head space is withdrawn with a gastight microcyringe and injected into the gas chromatograph. CO dissolved in saturated blood is also measured by head space analysis to ascertain that dissolved CO is able to be removed with only one shaking of blood with nitrogen (N2). N2 put into the head space previously is used as internal standard. The advantages of this method lie in the ease and speed of operation with a simple and widely available instrument.抄録全体を表示PDF形式でダウンロード (670K) -
田村 穣, 佐藤 憲雄, 森脇 隆, 多々見 晃, 江崎 洋志, 永沢 麗子, 青石 美恵子, 岡村 千鶴子, 須藤 三重子, 板東 丈夫, ...1980 年 5 巻 1 号 p. 45-78
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリー抗炎症性corticosteroidであるclobetasone-17-butyrate (C-17-B) について, マウスおよびラットにおける急性毒性ならびにラットにおける亜急性毒性を検討した。(1) C-17-BのマウスにおけるLD50は腹腔内投与では雌雄とも約5g/kgであり, 皮下投与では3.6 g/kg以上, 経口投与で6.0 g/kg以上であった。一方ラットにおけるLD50値は腹腔内投与で1.51 (雄)および1.66 g/kg (雌)であり, 皮下投与では2.6 g/kg以上, 経口投与では6.0 g/kg以上であった。(2) C-17-Bによる急性中毒症状としては, マウス・ラットとも被毛粗剛, 自発運動低下および著しいるい痩がみられた。大量投与群では胸腺・脾および副腎の萎縮等の変化を認めた。(3) C-17-Bを1ヵ月間皮下投与した亜急性毒性試験の場合, 0.1 mg/kg/day以上の投与量で雌雄ラットとも体重の増加抑制または減少がみられ, 1.0 mg/kg以上の投与量ではこの成長抑制に飼料消費量の減少を伴った。しかし死亡例は全く生じなかった。投与終了時の各種検査では, 0.01および0.03 mg/kg群で著変を認めず, 0.1 mg/kg以上の投与量群に投与量に併行した副腎, リンパ系または造血系臓器の退行性変化, 白血球数の減少, リンパ球百分比の減少, 血清total cholesterolの増加等が認められた。(4) C-17-Bの1ヵ月間投与による障害からの回復は, 1.0 mg/kg投与群では投与中止後2ヵ月目でほほ完全であった。(5) C-17-Bの急性および亜急性毒性試験においてみられた病変はいるれもglucocorticoids の一般的な毒性として知られているものだけであり, 本亜急性毒性試験におけるその最大無作用量は0.03 mg/kg/dayであった。抄録全体を表示PDF形式でダウンロード (5157K) -
山本 義為, 北島 裕子, 野村 正行1980 年 5 巻 1 号 p. 79-89
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーBasic experiments on safety evaluation of 0.3%, 1% and 3% solution of KW-1062 (DE-020 eye drops) were carried out. These eye drops applied topically to rabbits eyes had no undesirable local or systemic effects as follows : 1. Repeated instillations of DE-020 eye drops (One drop every 1 hr for 4 hrs) showed no significant irritation except only a temporary and slight congestion localized at the conjunctivae. 2. Daily instillation of DE-020 eye drops (3 times daily for 28 days) showed no abnormal findings in the eye mucosa, clinical signs, body weight, hematological examination, biochemical examination, autopsy, organ weight and histopathological examination.抄録全体を表示PDF形式でダウンロード (1245K) -
中川 静紀, 政本 浩二, 住吉 博道, 国弘 和雄, 不破 亨1980 年 5 巻 1 号 p. 91-112
発行日: 1980/02/15
公開日: 2008/02/21
ジャーナル フリーThe effects of peroral administration of raw garlic juice and extracted-aged garlic juice (garlic extract) were studied with female Wistar strain rats. For the examination, 5, 5 and 10 rats were sacrificed after 3, 8 and 21 days respectively. In the group to which raw garlic juice (5 ml/kg) was administered 5 rats died of the serious stomach injury in 21 days and body weight of still living rats was down at the begining as food and water intake were decreased. The growth of rats to which raw garlic juice administered group was retarded. The retardation of growth was thought to be caused by the stomach injury due to raw garlic, which limited in fundus. The injured section of stomach was not far gone by the longer administration, however, the mucous secretion of the surface and neck area were stimulated. Swelling of the liver, hypertrophy of the spleen and adrenal glands, and the decrease of erythrocytes with various morphological changes were clearly observed after 3 and 8 days on the group dosed high raw garlic juice, but almost these changes were not observed at any time on extracted-aged garlic juice administration.抄録全体を表示PDF形式でダウンロード (2420K)
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