東京女子医科大学雑誌
Online ISSN : 2432-6178
Print ISSN : 0040-9022
ISSN-L : 0040-9022
87 巻, 5 号
選択された号の論文の3件中1~3を表示しています
目次
総説 循環系の基礎と臨床
  • 江﨑 太一
    2017 年 87 巻 5 号 p. 135-145
    発行日: 2017/10/25
    公開日: 2017/10/25
    ジャーナル フリー

    Research on the lymphatic vascular system has made relatively slow progress compared to that of the blood vascular system. The major reasons for this include a lack of reliable techniques for the identification of lymphatic vessels in tissue, and that blood circulation is considered to be directly connected with life, and therefore requires urgent investigation of associated pathogenesis and treatments. However, in recent decades, research on the lymphatic system has made remarkably rapid progress because of the discovery of specific markers for lymphatic endothelial cells, various factors and genes relating to their proliferation and regeneration, and also significant advancements in lymphatic vessel imaging techniques. We have entered a new era of lymphatic system studies in both basic and clinical research fields. The importance of lymphatic vessels in local microcirculation is being realized through improved understanding of the functional significance of the lymphatic system in the normal body fluid circulation, and its contribution to defense against various infections and cancers. The establishment of treatments for lymphatic diseases relating to edema (lymphedema), immune disorders including organ transplantation, and lymphogenic metastasis of malignant tumors is a matter of great urgency. In the present review, I present the phylogeny, ontogeny, and mechanisms for lymphangiogenesis/lymphvasculogenesis, and report some important disorders relating to lymphangiogenesis, and discuss promising recently published strategies for their treatment.

原著
  • 野原 理子, 冨澤 康子, 齋藤 加代子
    2017 年 87 巻 5 号 p. 146-150
    発行日: 2017/10/25
    公開日: 2017/10/25
    ジャーナル フリー

    Purpose: In Japan, although much effort has been made to promote the work-life balance of women and to achieve a society with prosperity and vitality, consideration of working environment including childcare support is still behind. It is necessary to construct an effective system to support childcare for both men and women. This study aimed to examine the system of sick child leave and improvement of childcare environment, by investigating the situation of absence due to illness among nursery children in Tokyo.

    Methods: All the children who attended three nurseries in Tokyo between April 2011 and March 2016 were studied. The investigation was conducted for 4 days during August 2016. Data for age, sex and days of absence due to illness were extracted from either the attendance lists or health records of the children in each nursery for the period of 2011-2015. Children who were absent for the whole month were excluded from analysis for that month. This study was approved by the Tokyo Women's Medical University Ethics Committee (Approval Number 4040).

    Results: A total of 1,834 children (989 boys and 845 girls) were studied. The average annual number of days of absence due to illness per person by class was 19.3 days in the 0-year-old class. The number decreased with age, and was 5.4 days in the 5-year-old class. The average frequency of sick absence per month was the highest in July and the lowest in June.

    Conclusion: The present study showed that sick absence was the highest among the 0-year-old nursery children, indicating that a fine-tuned childcare support system such as allowing more sick child leave in the first year may be helpful to improve working environment.

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