東京女子医科大学雑誌
Online ISSN : 2432-6178
Print ISSN : 0040-9022
ISSN-L : 0040-9022
88 巻, 1 号
選択された号の論文の12件中1~12を表示しています
目次
総説 悪性腫瘍の最先端
  • 山本 俊至
    2018 年 88 巻 1 号 p. 1-5
    発行日: 2018/02/25
    公開日: 2018/03/06
    ジャーナル フリー

    Precision cancer medicine is a medical practice that optimizes therapy, predicts prognosis, and prevents the onset of diseases through the use of genomic information from cancer tissues. Recent progress in comprehensive genetic analyses using next generation sequencing and various molecular targeted drugs for cancers with specific mutations have enabled us to use precision cancer medicine. When comprehensive genetic analyses are performed on cancer cells, many genetic mutations will be revealed. Among them, driver mutations in known therapeutic targets should be identified. For this purpose, the knowledge of bioinformatics is necessary. Furthermore, bioinformatics provides unintentional, secondary findings in about one in 10 people. Therefore, pre- and post-genetic counselling would be required. In conclusion, the use of precision cancer medicine should involve a team, so that it is implemented with correct understanding of the benefits obtained and the disadvantages that may occur due to comprehensive genome analyses.

原著
  • 宇治原 典子, 長谷 美智代, 大澤 真里, 三坂 亮一
    2018 年 88 巻 1 号 p. 6-11
    発行日: 2018/02/25
    公開日: 2018/03/06
    ジャーナル フリー

    We investigated the incidence of diabetes and risk factors for the onset of diabetes among elderly individuals with impaired fasting glucose (IFG) who visited the Institute of Geriatrics at Tokyo Women's Medical University for check-ups in 2007. Among 300 individuals (mean age, 70.7±7.3 years) with fasting plasma glucose (FPG) 100-125 mg/dl at baseline, 20 subjects (6.7 %) showed diabetes after 5 years. Of the 82 subjects with FPG 110-125 mg/dl, which is currently used as the cut-off for IFG in Japan, 17 (20.7 %) were diabetics after 5 years. Based on logistic regression analysis (stepwise method) for participants with FPG levels between 100-125 mg/dl, significant risk factors for onset of diabetes within 5 years included hemoglobin (Hb) A1c (odds ratio (OR) 65.089, 95 % confidence interval (CI) 4.329-978.571, p=0.003), FPG (OR 1.141, 95 %CI 1.043-1.248, p=0.004), AST (OR 0.816, 95 %CI 0.711-0.936, p=0.004), and history of stroke (OR 8.088, 95 %CI 1.109-58.987, p=0.039). For participants with FPG levels ≥ 110 mg/dl, HbA1c (OR 105.93, 95 %CI 3.658-3,068.165, p=0.007), triglyceride (TG) (OR 1.028, 95 %CI 1.007-1.050, p=0.01), AST (OR 0.814, 95 %CI 0.685-0.968, p=0.02), and history of stroke (OR 16.09, 95 %CI 1.429-181.224, p=0.025) were significant risk factors. These findings suggest that early intervention in lifestyle is an effective means of preventing the onset of diabetes in elderly individuals.

第83回東京女子医科大学学会総会 シンポジウム
学会・研究会抄録
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