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Volume 34 (2012)
- Issue 4 Pages 285-
- Issue 3 Pages 217-
- Issue 2 Pages 151-
- Issue 1 Pages 1-
Volume 34, Issue 4
Displaying 1-10 of 10 articles from this issue
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[Short Report]
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Akemi HOSODA, Yasuji OKAI, Emiko KASAHARA, Masayasu INOUE, Masatomi SH ...2012 Volume 34 Issue 4 Pages 285-296
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSTo estimate the potent immunomodulating effects of different types of traditional Japanese millet, we analyzed the effect of bran extracts of foxtail millet (Awa in Japanese), barnyard millet (Hie) and proso millet (Mochi-kibi) on nitric oxide (NO) and inflammatory cytokine production induced by lipopolysaccharide (LPS) in a mouse macrophage cell line (RAW264.7 cells). All methanol extracts of these millet brans showed suppressive activities against the production of NO and inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and Interleukin (IL)-6 in LPS-stimulated macrophages, which were not responsible for their cytotoxic activities. These immunosuppressive activities were roughly proportional to the contents of the phenolic compounds in their extracts. Especially, the extract of proso millet exhibited the strongest immunosuppressing effect, which was associated with the highest content of phenolic compound. However, the extracts did not exhibit significant suppressive effects on the production of an anti-inflammatory cytokine, IL-10, in the same macrophage culture system. These results suggest that traditional Japanese millets have potent immunomodulating activities against the production of NO and cytokine production in activated macrophages.View full abstractDownload PDF (1104K) -
Yasumasa EGUCHI, Masanori OHTA, Tomohiro INOUE, Toru HONDA, Yusaku MOR ...2012 Volume 34 Issue 4 Pages 297-308
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSInterval training is effective for promoting aerobic capacity and general health. However, it involves repeated high-intensity activity, which could pose cardiovascular risks for the elderly or people who are less fit. We developed a transitory stimulation interval exercise (TSIE) in which the duration of strenuous exertion was reduced to 30 seconds at 75% Vo2max of intensity. This pilot study aims to explore the effects of this mode of exercise. Thirty women were randomized and stratified into the TSIE group, the continuous moderate exercise (CME) group, or the no-exercise (NE) group. The two exercise groups performed exercises for 12 weeks. Significant positive changes were observed in the TSIE group compared with the NE group in the relative change ratio from baseline in body weight and Vo2max, but no significant differences were observed between the CME group and the NE group. Glycated hemoglobin A1c (HbA1c) decreased significantly in both exercise groups compared with the NE group. Overall, there were few significant differences between the CME group and the TSIE group. There might not be any differences between the TSIE and the CME in a long term intervention with equalized training volumes.View full abstractDownload PDF (998K) -
Toshiyuki HARA, Ken TAKAHASHI2012 Volume 34 Issue 4 Pages 309-313
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSThe elevated risk of lung cancer among chromate-producing workers has been confirmed by many epidemiological studies. Although chromium has been most used in the chromium plating industry and many platers are employed in small-scale factories, cancer studies have been documented in only a few investigations. We have conducted several prospective cohort studies in Japanese chromium platers and recently extended them through 2003. We additionally surveyed epidemiological studies among chromium platers carried out in other parts of the world. Occupational chromium exposure through chromium plating work may be a risk factor for mortality not only from lung cancer but also malignant lymphoma and brain tumor. The age at first exposure to chromium may be a more important factor than the duration of exposure for an increased risk of lung cancer and malignant lymphoma.View full abstractDownload PDF (509K)
[Review]
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Toru ISHIKURA, Hitoshi SUZUKI, Takanori MATSUURA, Hideo OHNISHI, Toshi ...2012 Volume 34 Issue 4 Pages 315-321
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSPhysiological response to acute and chronic nociceptive stimulation are important for living organisms. In our laboratory, we generated transgenic rats expressing the arginine vasopressin (AVP) and enhanced green fluorescent protein (eGFP) fusion gene, and the c-fos and monomeric red fluorescent protein 1 (mRFP1) fusion gene in the central nervous system. We made it possible to visualize the pain response in the living cells. Using these transgenic rats, the aim of our studies is the elucidation of the physiological role of AVP after nociceptive stimulation and the pathophysiology of work-related pain. We describe the previous findings of nociceptive response, using these transgenic animals.View full abstractDownload PDF (2569K) -
Hiroko MORI, Yosuke OKADA, Yoshiya TANAKA2012 Volume 34 Issue 4 Pages 323-329
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSVitamin D deficiency increases the risk of type 2 diabetes mellitus, cardiovascular, hypertension, cancer, infectious and autoimmune diseases, as well as the risk of fractures. The major causes of vitamin D deficiency are lack of adequate vitamin D from dietary sources and avoidance of sensible sun exposure, amongst many others. Particularly, in women, vitamin D deficiency and insufficiency are common medical problems with insidious health consequences. The control of Vitamin D is important for many women to continue working longer in good health.View full abstractDownload PDF (866K) -
Hiroyuki MORIMOTO, Ryoko BABA2012 Volume 34 Issue 4 Pages 331-338
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSThe α subunit of eukaryotic initiation factor-2 (eIF-2α) is a molecule related to the first step of protein synthesis initiation in eukaryotes. eIF-2α is phosphorylated in response to a wide variety of stimuli, including viral infection, starvation, ischemia, and heat shock. Four mammalian eIF-2α kinases have been reported: PKR (double-stranded RNA dependent protein kinase), HRI (heme-regulated inhibitor), GCN2 (general control non-derepressible 2), and PERK (PKR-like endoplasmic reticulum kinase). Each kinase contains unique domains that recognize a different cellular stress and transmits the signals to eIF-2α. Hence, eIF-2α is considered to be a key molecule in integrated stress response. Understanding eIF-2α as a component of the integrated stress response may be helpful in revealing stress sitmulus and the responses to stress at the cellular level. This knowledge will contribute to the development of preventive and therapeutic approaches to stress mediated diseases.View full abstractDownload PDF (689K)
[Report]
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Keiko YANAI, Hiromi KODAMA, Kayoko TSUNEMATSU2012 Volume 34 Issue 4 Pages 339-351
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSForensic nursing is the application of forensic science to nursing. It provides direct patient care with relation to violence, abuse, crime, victimization and exploitation. Forensic nurses integrate forensic and nursing sciences in their assessment and care of victims and perpetrators. In the U.S.A., Canada and Europe, forensic nursing practice involves advocating for the collection of evidence and reporting of crimes. Additionally, forensic nurses treat victims and perpetrators for their trauma, their families, communities and the systems that respond to them. Through its practice, forensic nursing contributes to public health by preventing health hazards caused by violence and crime. This report considers the possibility of the development of forensic nursing in Japan. We propose that the development of forensic nursing is necessary.View full abstractDownload PDF (1173K)
[Case Report]
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Akira KUROZUMI, Yosuke OKADA, Keiko NISHIDA, Sunao YAMAMOTO, Hiroko MO ...2012 Volume 34 Issue 4 Pages 353-361
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSA 49-year-old man was referred to our clinic for suspected hypoglycemic symptoms of palpitation, cold sweat, faintness and sinking feeling at movement since 43 years old. The 75 g oral glucose tolerance test showed a decrease in plasma glucose to 56 mg/dl at five hours, but this was not associated with clear hypoglycemic symptoms, and normal plasma glucose level recovered naturally after the test. At 48-hour fasting test, plasma glucose dropped to under 50 mg/dl, but the patient didnʼt feel hypoglycemia symptom and plasma glucose recovered naturally, but the patient developed cold sweat and hyperventilation after returning to his own room after the test. At that stage, the heart rate increased to 140 beats/min of sinus tachycardia, as confirmed by Holter monitoring. Postural orthostatic tachycardia syndrome (POTS) was suspected because tachycardia occurred only in daytime after an event such as consumption of diet and urination. A head-up tilt test was ordered since sinus tachycardia developed especially on standing. The results showed an increase in heart rate without reduction in blood pressure, confirming the diagnosis of POTS. A repeat head-up tilt test under the use of a β-blocker showed no increase in heart rate. Though it is generally difficult to distinguish POTS from other forms of tachyarrhythmia, such as inappropriate sinus tachycardia and sinus node reentry tachycardia, and from neutrally mediated reflex syncope (NMS), POTS should be differentiated from hypoglycemia since each condition should be treated differently.View full abstractDownload PDF (1528K)
[Short Report]
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Hajime HORI, Sumiyo ISHIMATSU, Yukiko FUETA, Mitsuo HINOUE, Toru ISHID ...2012 Volume 34 Issue 4 Pages 363-368
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSMeasurements of organic solvents in the work environment are carried out by either direct sampling using plastic bags/gas chromatography, solid sorbent adsorption using charcoal tubes/gas chromatography, or by a direct reading method using detector tubes. However, these methods cannot always measure the work environment accurately because the concentration of hazardous materials changes from time to time, and from space to space. In this study, the sensor characteristics of a real time monitor using a photoionization detector that can monitor vapor concentration continuously were investigated for 52 organic solvent vapors that are required to be measured in the work environment by the Ordinance of Organic Solvent Poisoning Prevention in Japan. The sensitivity of the monitor was high for the solvents with low ionization potential. However, the sensitivity for the solvents with high ionization potential was low, and the sensor could not detected 7 solvents. Calibration of the sensor using a standard gas was desirable before being used for measurement because the sensitivity of the sensor was variable.View full abstractDownload PDF (661K)
[Contents of Volume 34 (No.1-4)]
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The University of Occupational and Environmental Health2012 Volume 34 Issue 4 Pages 369-379
Published: December 01, 2012
Released on J-STAGE: February 28, 2013
JOURNAL FREE ACCESSDownload PDF (773K)
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