Journal of UOEH
Online ISSN : 2187-2864
Print ISSN : 0387-821X
ISSN-L : 0387-821X
最新号
選択された号の論文の13件中1~13を表示しています
  • 岡井(東) 紀代香, 竹之内 明子, 小川 彩, 岡井 康二
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 1-13
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    We found an effective roasting method that enhances the effects on various radical scavenging activities of polysaccharide (alginic acid) derived from the marine brown alga Lessonia trabeculata. These enhancing effects were observed by a roasting treatment under relatively high temperature conditions (160ºC and 180ºC), which were measured by (i) a stable radical compound diphenylpicrylhydrazyl (DPPH), (ii) a hydroperoxide generating system of linoleic acid autooxidation, and (iii) an opsonized zymosan (Opz)-induced oxygen radical generating system in human blood neutrophils. Although a significant enhancing effect of the roasting treatment on the radical scavenging activity of the alginic acid itself was not detected under relatively low temperature conditions (100ºC and 130ºC), the roasting treatment of a mixture of alginic acid and several specific amino acids caused considerable radical scavenging activities under the same roasting conditions. When alginic acid was roasted at relatively high temperatures (160ºC or 180ºC), the mixture of the alginic acid and specific amino acids exhibited much higher radical scavenging activities than did the alginic acid alone. The significance of this finding is discussed from the viewpoint of healthy food science.

  • 酒井 咲紀, 永田 昌子, 永田 智久, 森 晃爾
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 15-23
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    The purpose of this study was to examine whether Foods with Function Claims (FFC) containing asparagus extract effectively improved sleep quality and work performance in shift workers. An intervention study with a before-and-after intervention design was conducted on nurses engaged in two-shift work at a hospital, ingesting a FFC containing asparagus extract. The evaluation period lasted at least two weeks, including three nights shifts during the period. Before and after ingestion, Pittsburgh Sleep Questionnaire Index (PSQI), Utrecht Work Engagement Scale (UWES), Sleep quality (VAS-rated), impaired work functioning, and psychiatric symptoms were evaluated. A diary record, wearing of an activity meter, and a Psychomotor vigilance test were also performed at baseline and after intervention. Data were analyzed by the paired t-test or the Wilcoxon rank sum test. Among 34 participants, 33 completed the study. The results of the primary outcome measures showed significant improvements in PSQI and Sleep Quality in the night of the day after a night shift (PSQI total score: base line 7.41/ post intervention 6.03: P < 0.001; sleep quality: base line 4.48/post intervention 6.00: P < 0.001). The results of the secondary outcome measures showed significant improvements in UWES and feeling of fatigue. There was also trend of improvement in sleep efficiency and the reaction time. There was no significant improvement in impaired work functioning. This study showed that regular consumption of an FFC containing asparagus extract could improve sleep quality, feeling of fatigue, and work engagement among shift workers. Some caution, however, is needed when interpreting the results because of the before-and-after intervention design without a control group.

  • 大津山 彰
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 25-31
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    In the event of a high-dose radiation exposure accident, adipose-derived stem cell (ADSC) transplantation might be used as an emergency medical treatment to compensate for bone marrow failure. To investigate the possible course of that treatment, we examined whether transplantation of ADSCs into whole-body X-ray irradiated mice would provide resistance to radiation damage. ADSCs were obtained from a primary culture of adipocytes from adipose tissue of syngeneic mice. The ADSCs were transplanted via an intravenous (i.v.) route after whole-body irradiation (6 Gy, X-rays) of the ICR mice. Fifty days after transplantation, the survival rate of the transplanted group was 40% higher than the control group, and the difference in survival rates was maintained in the following 200 days. After 400 days, however, the difference in survival rates became smaller and disappeared after 650 days. The results indicate that ADSC transplantation may reduce lethality from acute radiation bone marrow injury for several hundred days.

  • 天野 徹哉, 田中 繁治, 伊藤 秀幸
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 33-39
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    This study examines factors associated with activity limitation and the decline in quality of life in patients with knee osteoarthritis (OA), and to determine standard values that would be useful for understanding the disease state. We assessed individual factors, the modified version of the Self-Rating Frenchay Activities Index (SR-FAI), and the Japanese Knee Osteoarthritis Measure (JKOM) of 661 participants. Multiple regression analyses were used to examine the relationship between dependent and explanatory variables. Standard values were calculated after stratifying based on factors related to each dependent variable through multiple regression analyses. Among the participants aged 60-74/75-89 years, the standard values for the modified SR-FAI were 23/19 and 20/18 points for K-L grades III and IV in the males, and 29/23 and 26/21 points in the females, respectively. The standard values for the JKOM were 35/49 and 45/59 points for K-L grades III and IV in the males and 41/52 and 47/60 points in the females, respectively. These standard values are a useful index for interpreting the degree of activity limitation and satisfaction reduction in patients with knee OA, and could help in clinical decision making for healthcare providers.

  • 杉村 直哉, 江口 尚, 真船 浩介, 奥原 孝幸, 廣 尚典
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 41-50
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    In depression, the health condition of family members (particularly spouses) may influence the reinstatement process of employees on temporary leave. The length of leave from work may reflect the quality of the process leading to the stage of reinstatement, and a short period to reinstatement may increase the possibility of a smooth reinstatement. In this study we investigated the relationship between spouse factors and length of leave period. The subjects were 63 permanent employees on temporary leave for depression and their spouses. We investigated demographic characteristics, spouse factors, individual factors, household factors, and workplace factors, and extracted the factors related to the length of leave period through hierarchical multiple regression analysis. Results revealed that the Frenchay Activities Index (FAI), a spouse factor, was consistently and significantly related to the length of leave (β = −0.37, P < 0.01). The higher the spouse FAI, the shorter the leave period of employees on temporary leave. In particular, the spouses’ leisure activities were related to the leave period, whereas the effects of housework and work were unclear. The results suggest that the assessment and intervention of the spouses’ activities of daily living are important in reinstatement support.

  • 池田 智, 江口 尚, 廣 尚典, 真船 浩介, 古賀 佳代子, 西村 和美, 中島 充代
    原稿種別: [原著]
    2021 年 43 巻 1 号 p. 51-60
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    The primary purpose of this study was to clarify the path by which high job demands on home-visit nursing staff affect their mental health through work-family negative spillover (WFNS, FWNS). The secondary purpose was to clarify the path by which high job control and high social support in the workplace positively affect the mental health of nursing home-visit staff through work-family positive spillover (WFPS, FWPS). A cross-sectional survey using a self-administered questionnaire was conducted on 1,022 visiting nursing staff working at 108 visiting nursing stations in Fukuoka Prefecture in February, 2019. The measurement tools comprised sociodemographic factors, the Japanese version of the Survey Work-Home Interaction – NijmeGen (SWING-J), Job Content Questionnaire (JCQ-22), the Work-Family Culture Scale, and the K6 scale. Six models were determined in an analysis of the model: (1) working time load → WFNS → FWNS → psychological distress, (2) job demands → WFNS → FWNS → psychological distress, (3) job demands → psychological distress, (4) workplace support → job control → WFPS → psychological distress, (5) workplace support → WFPS → psychological distress, and (6) workplace support → psychological distress. This study clarified that job demands and working time load may adversely affect the mental health of home-visit nursing staff through the mediation of WFNS. It was also clarified that high job control and workplace support may have a positive effect on mental health through the mediation of WFPS.

  • 森 晃爾, 永田 昌子, 永田 智久
    原稿種別: [総説]
    2021 年 43 巻 1 号 p. 61-73
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    Productivity loss due to presenteeism accounts for a large proportion of economic losses caused by workers’ health problems. To reduce presenteeism, it is necessary to identify its causes, but, in contrast to the large amount of research on the effects of diseases and lifestyles, there is not enough research on the effects of work-related factors on presenteeism. In this study, those factors include the work environment and the work-related psychological status of workers. The purpose of this review was to identify research trends in presenteeism, defined as work-related productivity loss, and to examine future directions for presenteeism research. We conducted a search with only the keyword “presenteeism” using MEDLINE/PubMed for the last 5 years and extracted 30 relevant articles, most of which were cross-sectional studies. The articles were categorized into the following themes: 1) studies on the associations of various stress models and factors with presenteeism; 2) studies on the mediators and the pathways of association between stress factors and presenteeism; 3) studies on the relationships between organizational factors and presenteeism; and 4) studies on the link between workers’ positive and negative psychological status and presenteeism. Our findings showed that, over the last 5 years, the relationship between psychological stress and presenteeism has been extended to include a variety of stress models and stressors. In addition, by putting many models and factors into a single statistical model and adjusting for their interrelationships, important factors have been examined by ensuring that a significant relationship with presenteeism remains. As there is still a lack of longitudinal studies necessary to discuss causality, more research of higher quality is needed.

  • 秀島 宏典, 渡邊 龍之, 宮島 佑一, 久米井 伸介, 久米 惠一郎, 芳川 一郎, 原田 大
    原稿種別: [症例報告]
    2021 年 43 巻 1 号 p. 75-80
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    A 13-year-old boy was admitted to our hospital because of bloody stools. Although a Meckel’s diverticulum (MD) was suspected, capsule endoscopy (CE) revealed no remarkable findings. Seven months later, he was admitted again because of rebleeding. CE was performed again and revealed an elevated lesion and fresh blood in the ileum. A single balloon endoscopic examination revealed a diverticulum with an elevated lesion in it. Histologic findings showed ectopic gastric mucosa, thus we diagnosed this patient as having MD. Although CE is useful for the examination of obscure gastrointestinal bleeding, a single CE is not enough to diagnose MD bleeding. The timing in performing CE and the evaluation of other modalities would be valuable for patients suspected of having MD.

  • 青山 瑤子, 植田 多恵子, 倉留 洋平, 星野 香, 原田 大史, 金城 泰幸, 村上 緑, 鏡 誠治, 吉野 潔
    原稿種別: [症例報告]
    2021 年 43 巻 1 号 p. 81-86
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    A combination chemotherapy of paclitaxel plus carboplatin (TC) is the most frequently used regimen for gynecological malignancies. As long as it is effective, a carboplatin-containing combination chemotherapy is used for every relapse. This implies that the number of platinum administrations and the frequency of hypersensitivity reaction (HSR) increase as the prognosis improves. When a patient develops HSR to carboplatin, we have three options: 1) desensitizing and continuing to use carboplatin, 2) switching to other platinum drugs, or 3) changing to a non-platinum drug. Here we report an experience of an HSR to carboplatin in a patient with recurrent uterine carcinosarcoma. The patient was treated by surgery and TC therapy initially, resulting in no residual disease. The patient relapsed 18 months after the completion of the first-line chemotherapy and was treated with TC therapy again as second-line. An HSR to carboplatin occurred at the 10th cycle of TC in total. We replaced the carboplatin with cisplatin. A chemotherapy including cisplatin and adriamycin was repeated without further HSR. We reviewed the literature regarding HSR to carboplatin and in this paper we summarize the management for dealing with it.

  • 合志 清隆, 玉木 英樹, 石竹 達也
    原稿種別: [総説]
    2021 年 43 巻 1 号 p. 87-96
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    高気圧医学は救急・集中治療の1つである高気圧酸素治療(hyperbaric oxygenation: HBO)に潜水医学を含んだものである.HBOに関連した話題では放射線治療と再生医療があり,特に放射線治療におけるHBOの有効性を確認する臨床試験が進められている.さらに,頭部外傷,低酸素ないし虚血性の脳疾患でのHBOによる認知機能の改善が示されている.放射線治療の増感作用さらに再生医療におけるHBOの潜在的可能性は高いものと思われる.しかし,ランダム化比較試験の結果が重要視されるなかで,従来からの適応疾患である減圧障害,一酸化炭素中毒や重症軟部組織感染症などで有効性の再検討が必要と考えられる.また,減圧障害の治療に対する考え方が変わるなかで,潜水・潜函作業での事故対処も含めて規定している関連法令の見直しが迫られると考えられる.

  • 西尾 公佑, 岡田 洋右, 黒住 旭, 田中 良哉
    原稿種別: [症例報告]
    2021 年 43 巻 1 号 p. 97-102
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    症例は34歳女性.X-8年に慢性甲状腺炎と診断されたが,甲状腺機能は正常で経過した.X-9年悪性黒色腫の診断で外科切除および化学療法を施行した.X-1年11月左肺および左主気管支に転移を認め,遠隔転移を伴う根治的切除不能な症例に対して抗PD-1抗体であるニボルマブを投与された.X-1年12月ニボルマブによる無痛性甲状腺炎後の甲状腺機能低下症に対してレボチロキシンNaが開始となった.X年3月に効果不十分でありニボルマブは中止となったが,4月食欲不振,発熱,全身倦怠感を認め,血液検査にてcortisol 5.0,ACTH 17.5と低値を認め副腎不全と診断し入院した.ハイドロコートン投与により速やかに症状は改善し,頭部MRI検査で器質的病変なく,負荷試験ではCRH試験でACTH・コルチゾール共に低反応を認め,ニボルマブによるACTH単独欠損症と診断した.ヒドロコルチゾン15 mg内服で退院となった.ニボルマブによる甲状腺機能障害の副作用は国内で14.3%,海外で5.9%と高頻度に認める.しかし,続発性副腎皮質機能低下症に関しては海外臨床試験で0.3%程度の頻度で,甲状腺機能障害との合併発症の既報は少なく,比較的稀な症例と考えられたため報告する.

  • 豊福 篤志, 伊波 悠吾, 是枝 侑希, 吉田 昂平, 日暮 愛一郎, 笹栗 毅和, 永田 直幹
    原稿種別: [症例報告]
    2021 年 43 巻 1 号 p. 103-115
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー

    症例1は77歳,男性で,ECOG PS 0であった.近医にて糖尿病で治療中に血糖コントロール不良となり,腹部CT施行,S状結腸の壁肥厚を指摘,2020年3月当院に紹介された.精査の結果,S状結腸癌の診断に加え,前立腺癌とそれに伴う転移性骨腫瘍の診断となった.4月,腹腔鏡下S状結腸切除術を施行した.現在,術後6ヵ月であるが,前立腺癌とそれに伴う転移性骨腫瘍に対するホルモン療法中で,病勢コントロール良好である.症例2は86歳,男性で,ECOG PS 3であった.2020年8月発熱,腹痛を主訴に当院に救急搬送された.精査の結果,盲腸癌とそれに伴う閉塞性急性虫垂炎の診断に加え,前立腺癌とそれに伴う転移性骨腫瘍の診断となった.同月,腹腔鏡下回盲部切除術を施行した.術後,誤嚥性肺炎を繰り返し,43日目に永眠された.わずか5ヵ月間に大腸癌と前立腺癌の同時性重複癌症例を経験し,大腸癌における治療戦略として,近年増加の一途を辿っている前立腺癌との重複癌に関して,疫学的な考察も含め報告する.

  • 2021 年 43 巻 1 号 p. 117-163
    発行日: 2021/03/01
    公開日: 2021/03/05
    ジャーナル フリー
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