A raised multilobulated neoplastic mass appeared from the corneal surface of the right eye in a ten year old male Shih Tzu, which was receiving continued cyclosporine eye drop treatment for keratoconjunctivitis sicca (KCS). The mass was removed by a superficial keratectomy under inhaled isofulrane anesthesia. According to the histopathological examination, the mass was a squamous cell carcinoma. The carcinoma cells were corneal intraepithelial. Although some atypical cells, lymphocytes and plasma cells were apparent, the basement membrane was not affected. This is not an unusual outcome. Post operation, the corneal ulcer was treated with self-serum eye drop, antibiotics and a soft contact lens. After the corneal ulcer had healed, the KCS treatment with cyclosporine, which had been put on pause, was re-administered regularly until death. The dog had a relatively good QOL after surgery, however, a year and 5 months later, the dog died due to a metastasized carcinoma on the left side of the face.
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