Experiments were performed to make comparison between the influence of Halothane (H-I) and Ether (E-I) inhalation anesthesia on experimental intestinal obstruction (upper occlusion) in dogs, at the same time intact Halothane (H-N) and Ether (E-N) inhalation anesthesia for control anesthesia were carried out.
Comparison was made of clinical findings, blood pressure, blood gases and acid-base balance, blood components and body fluid.
The results were as follows:
1) After 96 hours of intestinal obstruction, decrease of body fluid and plasma chloride which were caused by a vomiting, at the same time increase of pulse rate, blood concentrate, hypotonia and a mild acidemia were recognized.
2) In E-I group, delay of time of the laryngo-pharyngeal reflexes were observed, and 2 heads of E-I group died without a completely awaking.
3) Body temperature, pulse rate and respiratory rate resulted similar effects in all groups (H-N, E-N, H-I, E-I) .
4) Arterial blood pressure depressed in intestinal obstruction groups (H-I, E-I) .
5) Halothane anesthesia groups (H-N, H-I) exhibited respiratory acidosis, and Ether anesthesia groups (E-N, E-I) showed mixed acidosis. Furthermore, intestinal obstruction groups (H-I, E-I) were more aggravating than control groups (H-N, E-N), particularity, E-I group maintained after the end of anesthesia.
6) Ht, Hb, plasma electrolytes and osmotic pressure did not change in all groups (H-N, E-N, H-I, E-I) .
7) Body fluid volume were not difference between H-I and E-I group.
From these results, it is presumed that use of Halothane inhalation anesthesia was better than Ether inhalation anesthesia on intestinal obstruction in dogs.

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The muscle relaxant, pancuronium bromide (PB), was examined for effect on dogs with the following results.
Muscle relaxation was apparent for 9.2 and 40.0 min. without respiratory depression by administration with 0.02 mg/kg (iv) and 0.05 mg/kg (im) of PB. Administration of 0. 05 mg/kg (iv), 0.08 mg/kg (iv), 0.08 mg/kg (im) and 0.11 mg/kg (im) of PB induced respiratory depression and arrest for 0, 15.7, 11.7, and 35.7 min. to return to a normal condition 37.7, 44.7, 62.3, and 94.3 min., respectively, after injection. The muscle relaxation induced 0.02 mg/kg (iv) of PB was effectively antagonized with 0.1 mg/kg (iv) of neostigmine, which was ineffective against a larger dose of PB (0.08 mg/kg (iv) ) . The effect of PB was enhanced under halothane anesthesia, where 0. 02-0.05mg/kg (iv) of PB induced respiratory depression or arrest. The remarkable side effect of PB was salivation, which could be prevented with atropine sulfate. In conclusion, PB can be applied to canine practice.

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Six clinically healthy mongrels were used repeatedly in the following experiments.
(A) Experiments of gradual induction of EAA on bilateral Sp-6 (G.I, experiments) : Load voltage was increased up to 6-7 Vp-p gradually within 60 min., and thereafter maintained for 40 min. (EAA: 5 cases, Control: 5 cases) .
(B) Experiments of rapid induction of EAA on bilateral Sp-6 (R.I. experiments) : Soon after i.v, injection of thiamylal sodium 12.5 mg/kg, b.w., load voltage was increased up to 15 Vp-p within 2 min., and thereafter maintained for 60 min. (EAA: 6 cases, Control: cases) . Clinical and hematological observations were performed periodically.
Results: (A) G.I. experiments
1) During the induction stage dogs were excited, while they were quiet during the maintenance stage.
2) Body temperature (T), pulse rate (P) and respiration rate (R) increased accompanying with the increace of load voltage, and decreased gradually during the maintenance stage.
3) WBC and neutrophil (%) increased gradually.
4) Plasma glucose was elevated during the induction stage, and thereafter reduced gradually.
5) No distinct changes were shown in Ht values, total serum protein (TP), plasma urea-N and total cholesterol.
Results: (B) R.I. experiments
1) Dogs were quiet or drowsy throughout the experiment.
2) In the early stage of induction, reduction of T and increase of P were observed, and thereafter T and P returned to normal gradually.
3) R showed no remarkable changes.
4) WBC and neutrophil (%) increased gradually.
5) Plasma glucose showed transient elevation.
6) No distinct changes were shown in the levels of Ht, TP, urea-N and total cholesterol.
These results supported the authers' view that EAA with premedication of thiamylal sodium was recommended.

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1) 硫酸アトロピン0.05mg/kgの前投与およびチナペンタールソーダ12.5mg/kg/min.で, 麻酔へ導入することが出来た。
2) 維持麻酔に使用したNew k・1型のエーテル気化器のダイアル3セットで酸素流量0.7l/分, 液温17℃前後で14%程度のエーテルガス供給濃度が得られこれにより安全な2時間の麻酔が行えた。
3) 体温は, 全例において下降を示し, 脈拍は, 増加の傾向を示したが, 心電図上は異常所見はみられなかった。
4) 呼吸は, 導入時に呼吸数, 換気量共に減少し, 5分後から回復に向かいはじめその後刻々と増加し, 60分経過頃の換気量は, むしろ麻酔前より20～30%上昇した。
5) 麻酔後, 赤血球数は減少, 白血球は増加の傾向を示し, 血糖値も上昇した。
6) 麻酔後, 尿蛋白ならびに血尿を呈する例があったが, 24～28時間後には回復した。
7) 山羊に対し, エーテル利用の閉鎖循環式吸入麻酔器そして気管チューブの利用により, 2時間に及ぶ安全な麻酔が可能である。

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臨床上おおむね健康と思われた仔ネコ45頭に塩酸ケタミンを5～100mg/kg筋肉内注射し, 一般臨床所見を経時的に観察して, 麻酔効果と副作用について検討した。
その結果, 塩酸ケタミンを仔ネコに用いる場合は, 筋肉内注射では30～50mg/kgの投与量が適当であり, 成ネコと同様の麻酔効果を得るためには, 成ネコより多くの投与量が必要であると思われた。

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Doxapram hydrochloride (dose: 0.5 mg/kg) was evaluated as a respiratory stimulant in horses under general anesthesia on two method.
Group 1 is premeditated with atropine sulfate and promazine hydrochloride, then casted by guaiacol glycerine ether and thiopental sodium.
Respiratory depression was produced by one shot-injection of 10% thiopental sodium lg/head.
Group 2 in premedicated and casted as a same method of group 1 and administered halothane until respiratory arrest. Both group's arousal time was shortend, minute and tidal volume, respiratory rate, blood pressure and heart rate increased.
Drug response occured with in 30 second (group 1) and spontaneous respiration appeared with in 90 second (group 2) after intravenous injection. apH and PaO₂ were increased and PaCO₂ was decreased in group 1. apH, PaO₂ and apH were recovered in group 1. apH, PaO₂ and apH were recovered in group 2.
No toxic or side effect was observed.

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