著者は, 出血性ショック犬に対するGOF麻酔下の調節呼吸が如何なる様式で成されるべきかを検討し, 併せて, その病態を研究するべく, 40ml/kgを急速に脱血させ, 死亡数, 臨床所見, 血圧ガス, 酸・塩基平衡, 血液性状について検討した。さらに, その対策として脱血液の再注入を実施し, その効果についても検討した。
1.調節呼吸下の脱血後無処置群では, 中心静脈圧, 股動脈圧の下降が著しく, 重度の代謝性アシドーシスを呈した。また, 血糖の上昇も著明で, それらの回復は遅れたほか, 気道内圧の上昇, PaO₂, PaCO₂の下降がみられ, 死亡した2例 (10例中) は特にPaCO₂の下降が顕著であった。
2.上記の群に脱血液を再注入すると, 血圧, 気道内圧は明らかに回復し, 代謝性アシドーシスも改善される傾向を示し, 全例とも生存して, 脱血液の再注入効果は明らかであった。一方, PaO₂は, 再注入後さらに下降したが, 笑気・酸素流量比2: 1を1: 1にすることにより改善された。また, 脱血液の代わりに他犬血液と乳酸加リンゲル液を注入した群では, 無処置群と脱血液再注入群の中間的な効果を示した。
3.脱血後のPaCO₂の下降と脱血液再注入後のPaO₂の下降が顕著でPaO₂は笑気・酸素流量比を1: 1にすることにより問題はないが, PaCO₂は換気条件を含めて今後の問題となった。
4.血液性状, 電解質は, 脱血後無処置群, 脱血液再注入群の違いによる著しい変化はみられなかった。

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It was studied on EEG, ECG and respiration curve those were during acute ashyxia with twenty-four anesthetized mongrel adult dogs by pentobarbital sodium (27.5 mg/kg by i.v.) and following results were obtained.
The result may show the intermittent flatening of EEG was started from just before the stoppage of respiration by experimental asphyxia. The intermittent flatening of EEG was changed to continuous flatening after stoppage of respiration till the artificial respiration is started. The EEG was recovered gradually after started artificial respiration. The period of no respiration were sixteen to eighty-seven seconds, but two cases of dogs were fail to recovered and those of no respiration periods were seventy-five and eighty-seven seconds. In the overdoses of anesthesia, which also may show the same condition of EEG. If it appears the intermittent flatening of EEG must be taken precaution. Even show the flatening of EEG, it can be recovered if the artificial respiration is started as immediately as possible.

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The purpose of this paper is to clarify the suitable ventilation volume, the air way pressure and the effects during controlled respiration at GOF anesthesia in dogs.
The suitable tidal volume was 23.3±3.9 ml/kg (M±S.D.) and the suitable air way pressure was 10.4±1.1 cmH₂O (M±S.D.) at intact chest.
The suitable tidal volume was 24.6±4.8 ml/kg (M±S.D.) and the suitable air way pressure was 10.8±1.7 cmH₂O (M±S.D.) at open chest. In effects of the suitable ventiration, the arterial blood pressure showed decrease of 23.2% at intact chest and decrease of 36.2% at open chest. PaO₂ showed a slight decrement in open chest. But these parameters retured to the pre-controlled respiration levels after spontaneous respiration. The remarkable variation of acid bace balance were did not shown during controlled respiration.

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Xylazine (0.8 mg/kg, body weight) was given intravenously to four horses and to three horses which were administered atropine sulfate (0.5 mg/head) intravenously 25 minutes before xylazine was given. Transient increase in systolic and diastolic arterial blood pressures, and brady cardia with atrioventricular block (A-V) were induced by xylazine. Bradycardia and A-V block were prevented by injection of atropine sulfate. In one horse, A-V block was present before treatment and the frequency of occurrence was increased signifificantly by the administration of xylazine. Blood pressure which initially increased tended to decrease to less than control values. There was no significant change in the partial pressure of blood gases or in the blood pH during the study period (60 minutes after administration of xylazine) .
Atropine sulfate should be administered before xylazine is given. It is desirable to use xylazine more carefully to the horse which has some abnormality in E.C.G..

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