Electroencephalographic patterns observed during increasing depth anesthesia with thiopental sodium-ether, with ketamine hydrochloride-ether and with pentobarbital sodium were correlated with concentration of anesthetic agents in the blood. Analysis of electroencephalogram was made by histogram method.
The results are as follows:
1) Before anesthesia phase; Beta band of 20-25 Hz waves were shown 60-70% following alpha band was 30%.
2) Induction phase; Delta band and theta band were increasing about 40% in place of beta band, but case of ketamine hydrochloride intervenous were increased beta band.
3) Maintenance phase; 20-30% ether gas inhalation 5 minutes, a few beta band increased when this stage ether concentration in blood was about 60 mg/dl. Ether concentration in blood was over 70 mg/dl increasing delta band and theta band appearance ratio.
4) Ether inhalation 30 minutes stage; Ether concentration in blood of 110 mg/dl when it was delta band only appearance ratio over about 50%.
It was suggested that this method of analysis is adaptable to the quantitative study of contribution of each anesthetic agents when used simultaneously, provided that a significant change in EEG patterns and frequency band (delta, theta, alpha and beta waves bands), subject to classification, is produced by the agents considered.
From the results of the present work, it was concluded that the changes EEG patterns were closely related to the depth of anesthesia and pharmacokinetics in the dog anesthetized with ether.

抄録全体を表示

Experiments were performed to investigate the n.euroleptic and circulatory effects following administration of flunitrazepam (Flu.), a new benzodiazepine delivertive, in comparison to diazepam (Dia.) . Twenty-eight adult mongrel dogs were divided into five groups, and these drugs were administrated intravenously (Flu. 0.3 and 0.1 mg/kg, and Dia. 3.0 mg/kg) and intramusculary (Flu. 0.5 and 0.3 mg/kg) . Physical status, systemic blood pressure, electrocardiogram, arterial blood gas tension, and arterial blood pH were investigated before and after administration of the drugs.
The results were as follows:
1. The neuroleptic effect of Flu. 0.3 mg/kg i.v. was better than that of Flu. 0.1 mg/kg i.v. and Dia. 3.0 mg/kg i.v.
2. After administration, salivation was found 12.5% in Flu. groups and 75% in Dia. group.
3. Systolic blood pressure transiently decreased immediately after administration in each group.
4. Heart rate increased immediately after injection in each group, but it was not significant in Flu. groups, while it decreased significantly after increasing in Dia. group.
5. Less obvious changes in electrocardiogram were found in all groups.
6. No significant change in body temperature was seen in Flu. i.v. group, whereas a significant decrease occurred in Flu. i.m. and Dia. i.v. groups.
7. Respiration rate increased in each group immediately after administration, thereafter decreased.
8. Both Flu. and Dia. gave rise to slight decrease of ventilation volume accompanied with changes of arterial blood pH and gas tension.

抄録全体を表示

Althesin which was known of a steroid anaesthetic agent was studied on anaesthetic and hemodynamic effects in cats. Twenty-two cats were used in this study. Two experiments were performed to research the effects of this agent. In the first experiment, hemodynamic effects were studied observing mean arterial pressure, heart rate, respiration rate, body temperature, blood gas and blood pH following administration of Althesin (0.78 ml/kg iv., 1.56 ml/kg i.m.) .
In the second experiment, the ovaro-hysterectomy was performed under anaesthesia of Althesin (1.56 ml/kg i.m.) for the purpose of clinical use.
Results are as follows:
1. Decrease of arterial blood pressure was observed in following administration of Althesin intravenously, and so, using it intravenously, great care must be taken.
2. Decrease of body temperature was observed in both following administration of Althesin intravenously (0.78 ml/kg) and intramuscularly (1.56 ml/kg), respiratory depression was observed apparently intravenously compared with intramuscularly.
3. Under anaesthesia of Althesin, disappearance of abdominal pain sensation and tension were observed, and ovaro-hysterectomy was performed easily.
These results suggested that operation of twenty to forty minutes' duration is possible.

抄録全体を表示

Twelve healthy beagles were given ketamine by the “Micro-Mini” drip administration technique and subjected to the general clinical examination and hematological tests. For the purpose of premedication before dripping ketamine they had been divided into four groups, which were premedicated with diazepam (Dz), droperidol (Dro), propyonylpromazine (Prop), and xylazine (Xyl), respectively. As a result, the following conclusions were drawn.
(1) The analgesic and anesthetic effects were satisfactory in the Prop and the Xyl groups, but were insufficient in the Dz and the Dro groups.
(2) Transient laryngospasm and respiratory obstruction were noticed immediately after the beginning of dripping ketamine and disappeard in several minutes, without any pharmacotherapy.
(3) Ketamine was examined for toxicity by the hematological test, which revealed no noteworthy changes at all.
(4) The dripping technique of ketamine was examined with regard to the total amount of transfusion administered, and the maintenance of and awakening and recovery from anesthesia. In consequence, it was clarified that these items of examination had been influenced remarkably with such types of drugs used for premedication as analgesics, sedatives, and anesthetics, and that full consideration should be given to the selection of a drug for premeditation.
From the results mentioned above it was indicated that the “Micro-Mini” drip administration technique of ketamine was influenced greatly with the type of drugs used for premeditation in the maintenance of anesthesia. If ketamine is used for anesthesia, taking this indication into consideration, it will be possible for ketamine to induce anesthesia which is safe from a clinical point of view, since ketamine was proved hematologically to be free from adverse effects.

抄録全体を表示