As the premeditation for an induction of narcosis by thiopental sodinm in dogs, various doses smaller than the conventional dose......25 mg/kg......were administered.
In the administeration with a half dose (12.5 mg/kg), animals were manifested suppression of breathing and their electrocardiographs showed the low voltage and ST deviation. They were observed badly frequently when the drug was injected rapidly.
A good result was obtained when administered with one-third doses at an adequate speed......injected 8.3 mg in 40 seconds.
The drug showed no effect of the premedication for an induction of narcosis when administered with one-forth of conventional doses.

View full abstract

Azeotrope (a mixture of halothane with diethyl ether azeotropic mixture) was tested on 210 dogs, from which the following results were obtained.
1) The time of induction and recovery in azeotrope anesthesia was almost the same as in halothane anesthesia. Sufficient safty was proved in high concentration and in long time inhalation (2-3 h.), in which no inhibition of cardiac or pulmonary functions could be observed.
A good balanced anesthesia was attained by the mixture of equal part of halothane and ether (1 : 1), judging from the findings of T.P.R. and P.T.G. (pneumotachogram), and the technical easiness is recommended for the clinical applications.
2) From the findings of electrocardiogram, the action of azeotrope was observed in the middle of the inhibitory action of halothane and the accelerating action of ether, by which high safety could be expected.
3) The decrease of blood erythrocyte and leucocyte counts and of values of Sahli and hematocrit were observed in surgical stage. The erythrocyte sedimentation test showed a higher speed in inductive and surgical stages. The findings of hemogram showed a heavy change in neutrophiles and lymphocytes, medium in eosinophiles, but none in monocytes and basophiles. In the transition of neutrophiles, the segment nucleus (2-3) showed a decrease in the surgical stage, but the segment nucleus (4-5) and stick nucleus no remarkable change.
4) The effect of various anesthetics upon blood pressure and respiration was the least in diethyl ether, followed by azeotrope and halothane, and the most in barbiturates.
From the results of the clinical and hematological observations and the experiments of the effect on blood pressure and respiration, azeotrope may be considered as an useful anesthetics, consisting of many advantages of ether and halothane, and their synergism.

View full abstract