Journal of Japan Veterinary Cancer Society
Online ISSN : 1884-3352
Print ISSN : 1884-3344
ISSN-L : 1884-3344
Volume 5, Issue 1
Displaying 1-8 of 8 articles from this issue
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  • Toshihiko Sato, Miki Sakonju, Hiroyuki Nanba
    2014 Volume 5 Issue 1 Pages 1-5
    Published: July 05, 2014
    Released on J-STAGE: July 05, 2014
    JOURNAL FREE ACCESS
    A 13-year-old, castrated male Labrador retriever was presented with a black, solid and rubbery mass at the right maxillary labial gingiva. Radiography showed that the maxilla was not invaded by the tumor. Histology of a core biopsy specimen suggested a tentative diagnosis of malignant melanoma. A partial maxillectomy including the mass and teeth was performed. Histopathological examination of the surgical specimen revealed a large amount of collagen fibers and neoplastic melanocytes that were quite similar to those of human desmoplastic melanoma. Metastasis to the regional lymph nodes was observed 5 months after surgery and to the lungs 13 months after surgery, when the dog died. To the best of our knowledge, this is the first clinical report on oral desmoplastic melanoma in the dog.
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  • Yuichi Hidaka, Akihito Kodama, Ryota Tamura, Masafumi Ito, Kouji Koike ...
    2014 Volume 5 Issue 1 Pages 6-11
    Published: July 05, 2014
    Released on J-STAGE: July 05, 2014
    JOURNAL FREE ACCESS
    A five-year-old female Miniature Dachshund was presented with abdominal distension and dyspnea. Physical, radiographical, and ultrasound examinations detected an abdominal mass and pleural effusion. The cytology of the mass and effusion indicated a malignant tumor, possibly of ovarian origin, with intrathoracic metastasis. Laparotomy demonstrated that the mass originated from the left ovary, and a complete ovariohysterectomy was performed. The histopathological examination revealed papillary adenocarcinoma in both ovaries. Paclitaxel/platinum combination chemotherapy was administered nine times to control pleural effusion, and the dog survived 623 days after the surgery. The postmortem examination confirmed that the metastatic tumor had spread to the lungs. Paclitaxel/platinum combination chemotherapy may be an acceptable option for treatment in dogs with metastatic ovarian adenocarcinoma.
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  • Norio Ushio, Yasuhiro Fukuyama, Takuya Maruo, Sinpei Kawarai, Takuo Sh ...
    2014 Volume 5 Issue 1 Pages 12-17
    Published: July 05, 2014
    Released on J-STAGE: July 05, 2014
    JOURNAL FREE ACCESS
    A 12-year-old spayed golden retriever was brought to our institute because of ptyalism and regurgitation. Thymoma associated with myasthenia gravis (MG) and megaesophagus was tentatively diagnosed based on chest radiography of a 2.5-cm mediastinal mass and a dilated air-filled esophagus, and the level of the acetylcholine receptor (AChR) antibody titer was found to be elevated to 5.23 nmol/L. The dog was first treated with pyridostigmine for 4 weeks to alleviate the symptoms of MG, followed by a single dose of radiotherapy at 12 Gy for the thymoma. One month after radiotherapy, the symptoms of MG were alleviated, and megaesophagus was not detected on chest radiography. Two months after radiotherapy, the AChR antibody titer was reduced to 1.58 nmol/L and no tumor was detected on chest radiography. The pyridostigmine therapy was discontinued 5 months after radiotherapy. At the 1-year and a half follow-up, the dog remained free of tumor and MG symptoms, and the AChR antibody titer was reduced to 0.6 nmol/L. In addition, no side effects of radiation were detected. This case suggests that administration of the acetylcholinesterase inhibitors before single-dose radiotherapy may be efficient against canine thymoma with MG and megaesophagus.
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