1. This drug displayed an excellent anthelmintic effect on canine hookworms when administered in 2 or 3 doses of 200mg (per kilogram of body weight; hereinafter omitted) between meals. Three doses are desirable for a light-weighing dog and one highly parasitized. 2. It gave a removal rate of 100 per cent of canine ascarids when administered in 3 doses of 200mg between meals. 3. The number of eggs of canine whipworms was reduced with 2 doses of 200mg given between meals. 4. This drug was not effective for the removal of canine tapeworms with the dose of less than 1, 500mg. 5. The fractional administration of this drug between meals revealed an outstanding anthelmintic effect on hookworms and ascarids and was free from side reaction which frequently appeared after the single administration of a large dose. 6. The drug could be given to a puppy affected with mixed parasitization of hookworms and ascarids and to a dog suffering from complications with hookworm parasitization, with effective anthelmintic results and no side reactions. 7. The effect of this drug was rapid in ascarids and relatively slow in hookworms.
1. Fourteen chemical and medical agents, including india ink and oxygen, were examined for the presence of microfilariae-driving effects. As a result, pilocarpine hydrochloride, daviol or pyrocatechin sodium disulfonate, filarsen or hydrochloride of dichlorophenarsin, and communin or filtrate of culture of Escherichia coli communior were capable of driving microfilariae. 2. Compared with these four agents with regard to the rate and degree of driving microfilariae and side reaction, supatonin or citrate of 1-diethylcarbamyl-4-methyl piperazin, which was studied by the authors in their previous experiments, was found to the fittest for the purpose of clinical diagnosis of canine filariasis.
Cows secreting abnormal milk were treated with Karuchinomin (an extract from the root of a perennial grass, Coix lacryrnas tobi typica), purasubitan (a proprietary preparation of calcium, magnesium, potassium and sodium salts, caffeine sodiobenzoate, glucose, and vitamin B1), or sodium propionate to examine the possible influence of these drugs on the quality of milk. As a result, fairly remarkable changes were observed when karuchinomin and purasubitan were administered. Especially, improvement was shown on the chemical composition of milk, suggesting the process of recovery to normal milk.
A collective outbreak of an infection character- ized with anemia occurred among imported Jersey cows in Okayama Prefecture.A type of Trypanosoma was isolated from 2 cows involved in the outbreak. From its morphological and other characteristics, this type was identified as Trypanosoma theileri or some closely related type. The virulent blood of naturally infected cows was inoculated to mice, guinea pigs, and rabbits with negative results. Artificial infection was successful in Jersey cows, in the circulating blood of which appeared trypanosomata. The isolated trypanosoma was easily propagated in N. N. N. media and kept by passage until the 17th generation. At autopsy, naturally infected fatal cases revealed hemorrhagic changes in the lymph nodes, skin, mucous membranes, subcutaneous tissue and intestinal tract, and the swelling of the spleen and liver. Artificially infected cows presented the swelling of the spleen, liver, and lymph nodes. Histologically, remarkable activation of the reticulo-endothelial system, hemosiderosis of the liver, kidney, and lymph nodes, increase of phasrna cells in the spleen and lymph nodes, local, lymphocytic, interstitial nephritis, and congestive spleen were observed. As the virulent blood contained a relatively large number of small piroplasmata as well as trypanosomata, these findings might have been caused by the pathogenicity produced by synergy of the two kinds of protozoa which are generally considered to be not so highly pathogenic. If the pathology of pure infection of either protozoa is clarified, the etiological analysis of mixed infection in the present cases will be feasible.