Adult worms of Dirofilaria immitis were found in the lateral ventricles of the brain of a dog suspected to be rabid. Such case as this seems to be very rare, though there is a report on the invasion. of these worms into the hepatic vein. The symptoms, anatomico-and histopathological findings are as follows:
1) Symptoms. The dog showed the symptoms of canine filariasis consisting of nervous symptoms of unknown origin, such as slight paralysis of the posterior half of the body, a few days before death and a symptom similar to epilepsy on the day of death.
2) Observations at autopsy. Anatomicopathologidal findings were not unusual in all the organs, except the brain and heart. The heart harbored about 40 worms of D. immitis in the right atrium. In the brain, a small spot of hemorrhage was found on the surface of the left piriform lobe, through which D. immitis got into the lateral ventricles. There was a large focus of hemorrhage near the site of invasion.
3) Histopathological findings. Microscopic examination revealed destruction, softening, and remarkable hemorrhage of the tissues. Glial-cell proliferation and perivascular cell infiltration were found around the tissues destroyed by D.immitis. No infiltration of eosinophil cells was observed.

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It is well known that arsenicals are very effective adulticides among the chemotherapeutic agents for canine filariasis. However, they often cause emesis or nausea. Promazine hydrochloride and chlorpromazine hydrochloride are phenothiazine derivatives known as medicines causing artificial hibernation they are effective in preventing emesis and nausea. With this knowledge, the authors conducted the present experiments.
Three different preparations were injected:
(1) arsenical (0.75-1.00mg As/kg of dichlorophenarsin hdrochloride) only, (2) mixture of the arsenical (the same amount as above) and promazine hydrochloride (0.5-1.0mg/kg), and (3) mixture of the arsenical (the same amount as above) and chlorpromazine hydrochloride 1.0mg/kg. Compared with (1), the other two were markedly effective in preventing emesis and nausea. Dogs administered with these preparations retained normal appetite and vitality, proving the desirability of using promazine hydrochloride and chlorpromazine hydrochloride with arsenical. There was no significant difference in results of experiment between promazine hydrochloride and chlorpromazine hydrochloride when used with the arsenical.
Additional experiments were conducted with the lethal dose (4.0mg As/kg) of arsenical. Some dogs were administered with the arsenical and promazine hydrochloride (2.0and 5.0mg/kg), and others with the arsenical and chlorpromazine hydrochloride (5.0mg/kg). As a result, the former dogs died, while the latter survived. Reactions of shock produced by the lethal dose of arsenical were dramatically averted by chlorpromazine hydrochloride (5.0mg/kg) and the dogs maintained their appetite and vitality.

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A survey was previously conducted of bacterial contamination and freshness of market ham and sausage in Hiroshima City. Furthermore, the same survey was carried out on these products during the manufacturing process in a plant. The results of the survey are as follows.
1. The numbers of surviving bacteria per gram were 2, 500-∞ in ham and 3, 600-86, 000 in sausage. No coliform bacteria, however, were found from either food. The amounts of volatile basic nitrogen per 100 grams were 5. 60-14. 56 mg in ham and sausage. The amounts of NO₂ were 2.99-13.80 ppm in ham and 1.64-5.91 ppm in sausage.
2. From the results of examination of bacterial contamination during the manufacturing process, it is supposed that the number of coliform organisms increased as the process progressed, but was reduced to zero during the process of smoking and boiling. Although the organisms other than coliform bacteria showed the same tendency, a number of organisms survived after the process of smoking and boiling. The amount of volatile basic nitrogen increased as the process progressed (9.51-15.53 mg in ham and 8.68-16.10mg in sausage).

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1. 新潟, 長野両県下で実施された乳牛の栄養障害の実態調査の一環として血・乳中VC濃度を測定した. 血中濃度については新潟県下のホルスタイン種および同系種218頭, 延625例の平均値は0.490mg/dl, ジャージー種は長野県富士見地区35頭, 延69例の平均値は0.657mg/dl長野種畜牧場17頭, 延68例の平均値は0.637mg/dl, また乳中濃度は新潟県下のホルスタイン種および同系種75頭, 延283例の平均値は2.073mg/dl, 長野種畜牧場のジャージー種17頭, 55例の平均値は2.856mg/dlで, 血中, 乳中ともジャージー種の方が高い傾向があった.
2. VCとそれに関連のある項目との関係を調査したが, 年間のVCの季節的変動, 血糖との相関関係は, 飼養条件が同一である長野種畜牧場がもっとも明瞭な傾向を示した. すなわち冬期から春期にかけて血中濃度は高く夏期低い. また高血糖, 低VCの傾向が認められた. 乳中濃度も冬期が最高であった. これら以外のものでは年令, 血清蛋白との間にわずかながら負の相関関係が認められた. しかし妊娠月数繁殖障害, 乳量, 尿中アセトン, グロス反応, 尿糖, TDN, DCPなどとの関係はとくに見出せなかった. これらのことはVCがストレスによって容易に変動するものであることから, 個々の要因との関係よりも体の動きとしてのVCの変動の方が大きいのではあるまいかと考えられる.
3. 乳房炎乳のVC濃度は乳質が分離したようなものは低濃度であったが, 肉眼的に乳質に異常のないようなものは正常乳と大差なく, 乳中白血球数とも相関関係はなかった.

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