No medicinal agents were found satisfactory to cure serious cases of acariasis, since none of m-ore than ten medicaments which had been applied by the author invaded the body of adult mites in foci of acariasis. In addition, it was presumed that a long-term application of some poisonous drug to the skin was injurious because of its inducing hepatitis or nephritis in a dog under treatment.
Therefore, the author avoided medicinal treatment and removed every mite and egg from foci by squeezing out, washing the skin carefully with lukewarm water. Unexpectedly effective results were obtained from this treatment of serious cases of acariasis in a short period of time. Only one treatment was sufficient to cure completely the affected skin of some dogs. It took not more than twenty days until such infested portion of the skin as deemed difficult to heal got remarkably better in other dogs.
It is desirable to use one or two per cent cresol-soap solution or the saliva of the dog to exterminate active mites-outside a focus, since these agents have acaricidal power.
Canine acariasis can be classified into the following three types:(1) asymptomatic acariasis, (2) mild acariasis, and (3) severe acariasis. The three types are derived from the difference in nature of Demodex folliculorum var. canis and microorganisms causing mixed infection and constitutional factors on the part of the dog, the last named of which the author considers to be hereditary.
The author is of the opinion that the susceptibility of a dog to acariasis may be dependent little on the length of hair, strength of the skin, and other acquired factors of the dog, but a great deal on some congenital potential predisposition which cannot be recognized clinically from outside of the body of the dog.

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Clinical symptoms were observed on large animals, mostly horses, administered with a single dose of chlorpromazine.
1. In horses, a dose of 1.0mg/kg injected by the intravenous (i. v.) route had a very specific, comparatively good tranquillizing effect. A longer time was needed until such effect was exhibited and less remarkable symptoms were manifested in the case of intramuscular injection than in the case of i. v. injection.
2. In horses, a dose of 1. 5-2.0mg/kg injected by the i. v. route caused severe ataxy, sleeping on the ground for a short time, and a very unusual attitude. The horses bent and spread out their fore limbs so widely that the anterior parts of the body almost touched the ground. They exhibited this appearance repeatedly, but seldom lay down on the ground in that condition.
3. Tachycardia due to administration of chlorpromazine was remarkable, especially in the case of large dosage. The respiration rate remained normal or decreased slightly, while no abatement of temperature was recognized beyond a limit of 0.5-1.0°C.
4. Other important clinical signs which had been observed in this experiment were specific sedative conditions and relaxation and dropping of the penis from the sheath.
5. In this experiment, the severity of symptoms did not always coincide with the dose administered.
It was supposed that this phenomenon was mainly due to individual variation. Therefore, carefull attention should be paid when the drug is used in practice.

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A survey was made to determine the incidence of Shigella in the feces and mesenteric lymph nodes of 467 cattle and 216 swine both slaughtered in Hiroshima Prefecture from November to December, 1959. The data obtained are summarized as follows.
1. Shigella flexneri 2b was encountered in the mesenteric lymph node of one of the 467 cattle (0.2%).
2. Shigella flexneri 2a were found in the feces of two of the 216 swine (0.9%).
3. No Shigella organisms could be found in the feces of cattle and the mesenteric lymph nodes of swine.
It had not been known in Japan that the organisms mentioned above had been found in cattle and swine.
It is well recognized that the two types found in this survey play an important role in outbreaks of human dysentery in Japan.
The significance of animals carrying such organisms may be self-evident in meat hygiene.

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Neutralization tests were performed with serum of a goat hyperimmunized with phenol-inactivated rabies vaccine, especially with serum collected from such goat on the 21 st day after the completion of immunization. As a result, 1.0cc of serum was capable of neutralizing more than 600, 000 mouse LD50.
Occurrence inhibition tests were carried out with immune serum on mice injected with rabies fixed virus.
Among mice injected with 0.05cc of immune serum, onset of rabid symptoms was inhibited in 100 per cent of those injected with serum 2 hours after virus injection, in 50 to 75 per cent of those 6 hours after virus injection, and in 75 to 100 per cent of those 12 hours after virus injection. On the other hand, the ability of immune serum of inhibiting the onset of rabid symptoms was reduced suddenly among those mice injected with such serum more than 24 hours after virus injection.
Besides, injection with 0.1 cc of immune serum is concerned, the effect of such serum on the inhibition of onset of rabid symptoms was exhibited in 75 per cent each of those injected with the serum 2 or 6 hours after virus inoculation, in 50 to 75 per cent of those 12 hours, and in 75 and 50 per cent of those 18 and 24 hours after virus inoculation, respectively. This inhibiting effect of immune serum showed a sudden decrease among mice injected with 0.1cc of such serum more than 24 hours after virus inoculation.
In complement fixation tests, the titer was 1: 8 in serum collected on the 14 th day and 1: 16 to 1: 32 in serum collected on the 21 st day.
These results indicate that immune serum prepared from a goat immunized against rabies fixed virus may display a considerable curative effect when it is used in an adequate dose at an appropriate time.
It is hoped that an excellent curative serum will be prepared in future by conducting scrupulous experiments on this type of immune serum with various species of animals.

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