It has been observed by Okinaka physiologically and clinically since a long time ago that the vagus nerve has partly a nature of the sympathetic nervous system. Of late, Okinaka et al. investigated the general distribution of the autonomic nervous system in the organic body and demonstrated histochemically the presence of sympathetic nerve fibers or cells in the vagus nerve.
The authors studied anatomically the vagus nerve innervating the esophagus of the goat. Then they confirmed some of the functions of this nerve by means of electric stimulation. Furthermore, they excised some part of the trunk of this nerve and observed the resulting disturbance of the swallowing action by cineradiography.
Moreover, serial investigation was carried out on the nerve-endings of the vagus nerve, particularly Auerbach's plexuses, located in various sites of the esophageal sphincter of the goat. As a result, it was demonstrated histochemically that monoamine oxidase (MAO) activity, which had been proved to be present exclusively in the area innervated by the sympathetic nervous system, existed in cells of the nerve-endings of the vagus in the esophageal muscle.
It is of particular interest to note that the most intense MAO activity of “nuclear positive type” (Tanabe, 1961), which is characteristic of the sympathetic nervous system, was proved to be present restrictedly and densely in Auerbach's plexuses at the upper and lower ends of the esophagus and in the labial, portion of the esophageal groove. From these results, it is strongly suggested that there may be an intimate relationship between these plexuses with such MAO activity and the receptors in the esophagus.
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