Nine piglets were used to study the anthelmintic effect of diethylcarbamazine (DC). Untreated contrl animals began to excrete worm eggs into the feces 28 to 30 days after experimental infection. Excreted eggs increased in number gradually and E. P. G. ranged from 200 to 1, 877 over the period of experiment. The lung harbored 167 to 238 wofms.
In animals injected intramuscularly with10O mg/kg of DC daily for 7 or 10 days beginnin on the 14th day after infection (a. i.), the feces contained no eggs and the lung harbored no worms. The same results were obtained from anirnals having received the same daily doses for 10 days begining on the 7th day a.i., but not from those having received 7 daily doses, instead of 10.In the latter, egg excretion was observed continually during a period beginning on the 30 th day a.i. The E. P. G. was about one-tenth of that of the control. The lung had 98 parasitic worms. The anthelmintic rate was 49 per cent.
A total of four courses of cyanacethydrazide treatment consisting of three consecutive dailysubcutaneous doses of 40 mg/kg each were given beginning on the 7 th, 14 th, 24 th, and 48 th days a.i., respectively. As aresult, changes in, E. P. G. were the Same as those observed in the untred Control, and the lung harbored 305 worms. Accordingly, hardly any effect was proved in this treatment.
Growth of piglets was apparently more accelerated in the DC-treated group than in the control. It was confimled the refore that DC treatment had a very pfonounced anthelmintic effect upon swine
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