Methyridine, in a form of injection, was examined for anthelmintic effect on swine nematodes in laboratory trials using 13 swine.
Tric huris suis and Strongyloides ransomi were completely removed by a dose of 150 mg or more of active ingredient per kilogram of body weight. The compound showed a low efficacy against Ascaris suum even when a dose of 500 mg/kg had been administered. It seemed to have no effect on Oesophagostomum spp. It was effective to reduce the egg count of Metastrongylus apri markedly. Only a small number of these worms were detected at postmortem examination on naturally infected swine which had been treated with a dose of 250 mg/kg or more. No satisfactory results were obtained from swine artificially infected and given a dose of 250 or 300 mg/kg.
A dose of as small as 150 mg/kg given by the intraperitoneal route resulted in causing a transient, severe systemicreaction. Therefore, this procedure was not suitable for swine. When injected subcutaneously, a dose of 300 mg/kg or less gave rise to a slight systemic reaction which was intensified with a increase in dosage. Death occurred a dose of 600 mg/kg, but not at a dose of 500 mg/kg. When a dose of 300 mg/kg or less, as divided into two equal aliquots, was injected subcutaneously at sites posterior to both ears, the resulting local reaction was mild in general.

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1964年9月にあひるのコクシジウム症に遭遇し, つぎのような知見を得た. 1) 発症したあひるは30日令の雛で, 元気食欲の減退または消失がみられ, 乳灰白色水様便が特徴的で80羽中32羽が弊死した. 2) 病理解剖所見では, 十二指腸, 小腸遊離部に針頭大充出血と粘膜にトーフ粕様乳灰白物が付着しており, 他の臓器には病変はみられなかった. 3) 病理組織学的所見として急性カタール性腸炎像がみられ, 粘膜上皮にガメートサイト, シゾントが認められた. 4) 糞便中よりオーシストを分離した. 大きさは17-21×13～15μでミクロパイルを有し, 壁は厚く25℃72時間で4コのスポロシストを形成した. 5) 分離オーシストを喋嚢内に投与して人工感染試験を行ない, 4日目よりオーシストが糞便中に排泄されたが7日以降は認められなかった. また, 乳灰白色水様下痢便, 緑色粘液便がみられた. 病理学的所見は, 野外例とほぼ一致したが軽度であった. 6) 今回分離したオーシストは, 従来報告されているものとは形態が異なるので新しい種類のものではないかと思われる.

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A total of 15 cases of intestinal obstruction in chickens were analyzed pathologically and examined for changes in egg production. They had been encountered in the Breeding Poultry Farm, Prefecture of Hiroshima, over a period from 1961 to 1964.
Of these cases, ten were induced by the formation of tumor, two by intussusception, two by the presence of a crude hair ball, and the other was by that of a piece of wood. Of the ten cases by tumorigenesis, seven were examined histopathologically and broken into four cases by adenocarcinoma, two by fibroma, and one by leiomyoma. In the four cases by adenocarcinoma, the carcinomata were chronic ones developed from the mucous membrane of the duodenum, jejunum, or ileum. Egg production was seriously damaged in the.cases by adenocarcinoma, where a long-lasting cessation of egg-laying was observed before death.

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It was clarified that infection with BEND virus is a new type of disease which belongs to the epizooticfever complex in cattle. This virus was proved to have been spread extensively among cattle in Japan. For the control of this viral infection, a new type of live virus vaccine is now under development. It is a mixed vaccine prepared from BEND virus and the hitherto known Kaeishi virus. It is the final objective of the field experiment now under way to apply this type of vaccine to young cattle.

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