Dithiazanine iodide in enteric coated tablets induces no vomiting after administration. It has been supplied since 1964 as a worming drug for whipworms, microfilariae of Dirofilaria immitis, hookworms, and ascarids in canine practice. It is usual that one tablet per 5kg of body weight of the dog is given per os, without fasting, once a day for 3 to 5 consecutive days. It is found, however, that the worming rate of the tablet is lower than the conventional method.
Forty dogs were observed 2 to 72 hours after administration of the tablet (a tablet per 5kg of body weight per os) at noon between morning (8 A.M.) and evening (5 P.M.). It was found that the lower worming rate was caused by an individual differencein the moving of the tablet from stomach to small intestine.
In other 40 dogs, the tablet was given at noon to dogs fasted during the morning, or 29 hours after the feeding. The individual difference decreased. The worming rate was higher than that in those given the tablet between the morning and evening feeding, with no fasting. In this experiment, 20mg/kg (for 2 days) and 4 mg/kg (for 5 days) of dithiazanine iodide were administered. Twenty mg/kg (2 days) gave rise to some ill-effects, such as adecrease in appetite.
Accordingly, the present method should be changed to the administration of 1 tablet per 5kg of body weight of the dog at noon every day for dogs fasted during the morning for 3 to 5 consecutive days.

抄録全体を表示

A case of bovine mastitis was found to have been caused by Candida albicans. At first, it was regarded as one of bacterial origin and subjected to antibiotic treatment, which was effective to alleviate the symptoms temporarily. Then it again manifested Mappetence, a fever showing a remarkable diurnal difference, and reddening and induration of the udder. Organisms of Candida albicans were isolated from milk samples collected each quarter of the udder.
The milk yield did not decrease in the acute stage of mastitis, but began to decrease suddenly on the 3rd clay of the febrile stage and was reduced to about half the regular yield on the 5th day of the same stage. After that, it increased gradually to the regular yield in accordance with the recovery from mastitis.
The milk revealed no noticeable changes in pH, but showed a marked coagulation at the beginning of the disease.
The patient was administered first with 12.5 million units of “mycostatin ” and then with one million units of “trichomycin ” per os 3 times daily for 5 consecutive days. As a result, the symptoms were alleviated, and the disease was cured completely in a month.

抄録全体を表示

大阪地方の鶏の呼吸器病症候群の病因分析の結果, 病毒としてはIBV, ILT, 鶏痘病毒が存在した.(ニューカッスル病毒は調査の対象外とした.)
密集地帯では同一養鶏場にIBVとILTVが同時に存在して, ヒナの育成中に感染し, 呼吸器病の大きな要因となっている. M. gallisepticum の検出はIBVの感染と密接な関係があつた. ILTVの感染とは関係がなかった. 呼吸器症状を呈するヒナ群85群の中, 上述の病毒の感染のない群よりM. gallisepticum を検出した件はわずかに2群であって, しかもこの2群はHaemophilus gallinarumとの混合感染であった. 大腸菌は各病毒に感染したヒナよりしばしば検出されたが, Haemophilus gallinarunz, フドウ球菌は18Vの感染に伴って検出される率が多かった。
M. gallisepticum Kp₃株を分与された農林省家畜衛生試験場, 安藤敬太郎博士に深謝する.
この論文の要旨は第59回日本獣医学会で報告した.

抄録全体を表示

Two cases, A and B, of hermaphroditism were found among Landrace swine kept at the prefectural experiment stations of Kagawa and Okayama, respectively. Case A was the testicular type of hermaphroditism and case B the bi-gonadal type.
The testis, with no scrotum, was relatively well developed in both cases. The ovary was present restrictedly on one side of the testis in case A. The uterus was almost as large as the normal one in case A, with yellow turbid fluid in its cavity. It was hardly developed in case B. The oviduct was not formed on the right side of case A, where the uterine horn became a blind end. It was present on the left side of case A and both sides of case B, running along the epididymis.
The ductus deferens took a remarkably winding course near the site where the uterine horn was attached to the ligamentum latum uteri. It ran parallel to that on the opposite side and opened at a site close to the orifice of the urethra. The prostate was observed in the submucocal tissue of the vagina in case A under the microscope. There was neither seminal vesicle nor bulbourethral gland.
Histological examination revealed marked hyperplasia of interstitial cells, hypoplasia and adipose degeneration of epithelial cells of the seminiferous tubules in both cases. There were necrotic foci surrounded by a thick layer of granulation tissue in the testis, acute catarrhal endometritis, diffuse cellular infiltration of the prostate and formation of lymph follicles in case A. Hypoplasia and necrosis were noticed in the granular layer of the ovary in case B.

抄録全体を表示