Experiments were carried out to examine the chemotherapeutic effect of 2-Sulfamoyl-4, 4'-Diaminodiphenylsulfone (SDDS), which had been found very effective against experimental acute toxoplasmosis in pigs, as well as in mice. Experiments were carried out to examine the chemotherapeutic effect of 2-Sulfamoyl-4, 4'-Diaminodiphenylsulfone (SDDS), which had been found very effective against experimental acute toxoplasmosis in pigs, as well as in mice. The minimal effective dose that would kill the parasite completely when the medication was started on a day after the appearance of obvious symptoms of this disease could be estimated to be around 10 mg/kg which should be given once daily for 7 days. At lower doses, or when the medication was delayed until 4 days after the illness appeared, SDDS was also very effective for suppressing the symptoms, although the parasite still remained in one or a few tissues of the treated pigs.
The authors found that frozen sections prepared in perfectly the same manner as those cut by the conventional microtome. When examined at lowpower magnification, these sections presented the cross sections of tonsillar crypts clearly. Only epithelial cells of the crypts were brilliantly green in sections positive for fluorescent antibody. At high power magnification, these positive cells were bright with green cytoplasm and had a black round nucleus, identified with quite ease. Accordingly, the fluorescent antibody technique with conventional frozen sections was found to be applicable to the diagnosis of hog cholera in the field in a rapid and simple manner.
Yoshikawa et al. have reported that they observed the morphological independency of M. zygomaticomandibularis (ZM) and M. maxillo-mandibularis (MMM) in the masticatory muscles in various mammals. The author tried to evaluate their observation by means of electromyography in the dog. In standing posture, tonic discharges appeared in M. temporalis and ZM. This seemed to be due to the proprioceptive reflex and, the charges varied easily with the alteration of the posture and emotional tension. In weak biting, moderate activity appeared in M. masseter and MMM on both sides, but in M. temporalis and ZM only on the biting side. Slight activity appeared in M. masseter and MMM as long as the mouth was open to such extent as not wide enough to accept feed in to the oral cavity. Moderate activity appeared in MMM, while the dog kept feed near the tip of the mouth. In strong biting, strong activity appeared in M. masseter and MMM on both sides. On the other hand, strong activity appeared in M. temporalis and ZM only on the biting side, when moderate activity was observed in the same muscles on the non-biting side. Of course, in opening the mouth, slight activity appeared in M. masseter and MMM. Moderate activity appeared in M. masster and MMM in the licking lip. This was attributed to the stretch reflex. Then slight activity appeared in all four muscles. Moderate activity in M. masseter and MMM and slight one in M. temporalis and ZM appeared in licking feed. In short, the activity pattern of MMM was different from that of M. temporalis, but similar to that of M. masseter. Judging from the muscular function, MMM could not be recognized as a part of M. temporalis.