Ampicillin, -or 6 [D (-)-α-aminophenylacetamido] penicillinic acid, was evaluated for. curative effect on bacterial diseases in 54 dogs and 14 cats. An attempt was made to isolate causative organisms and examine them fbr susceptibility to some antimicrobial agents. Ampicillin was injected once a day intramuscularly at a dose of 5-10mg/kg or administergd. orally at a dose of 25-40mg/kg. The results obtained are summarized as follows.
1. Of the 68 animals tested, 54 recovered well by the treatment of ampicillin. Good results were obtained from most of the animals affected with alimentary and urinary tract infections and from 80% or more of the animals suffering from suppurative dermatitides and respiratory tract infections. Only poor responses were observed in most of the cases of abscess, otitis and endometritis.
2. Various species of Staphylococcus, Proteus, Escherichia, Streptococcus, and Pseudoxnonas were isolated from 32 of 39 animals examined prior to the treatment. Staphylococci and Gram-negative bacilli were frequently isolated from suppurative dermatitides and respiratory tract infections, respectively.
3. Ampicillin was significantly effective against about 90% of the strains, inhibiting the growth of both Gram-negative and positive organisms. Its antimicrobial activity was similar to that of tetracycline or chloramphenicol.
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