Hematological and pathological examinations were carried out on 9 cats which had died of spontaneous feline panleukopenia and 16 cats experimentally infected with this disease, including 5 fatal ones. Blood ests revealed severe leukopenia and thrombopenia in all the cats. In the experimentally infected cats both leukocyte and thrombocyte counts reached a minimum3-5 days after inoculation. They returncd to a normal level later in the surviving cats, but continued to decrease in the dead cats. Leukocytes decreased remarkably due to an obvious decrease in neutroplils and lymphocytes. There were no changes in erythrocyte count.
Pathological examination revealed hypoplasia of granulocytes, lymphocytes, erythroblasts, and megakaryocytes in bone marrow, mesenteric lymph nodes, and spleen in the dead cats, as well as necrosis and degeneration in the mucous membrane of the small intestine. It revealed foci of proliferation of blood cells in the hemopoietic organs in the surviving cats.
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