Poor appetite, polydypsia and emaciation were observed in a yearling heifer of the Japanese Black breed. The urine was acid, ketonuric, and glycosuric. Blood chemical studies indicated hyperglycemia (230 mg/d
l) and a high level of plasma NEFA (1.051 mEq /
l).
The glucose tolerance test (GTT) was performed and characterized by glucose intolerance with an abnormally long half time. The plasma glucose recovered its initial level (300 mg/d
l) after 6 hours. There was no rise in plasma insulin level (less than 6 μU/m
l) in response to GTT.
Xylitol which is highly effective to activate insulin secretion was administered, but there was no rise in plasma insulin, either. When 200 units of lente insulin was administered, plasma insulin was raised to the level of more than 200μU/m
l up to 6 hours and caused a decrease of plasma glucose to half of its initial level.
At necropsy, the pancreas was grossly normal. Microscopically, chronic pancreatitis was observed with lymphocytic infiltration into the interlobular and perivascular tissue and areas assumed to be pancreatic islets. As a result, most of the islets were atrophic to disappear eventually. Chronic glomerular and interstitial nephritis and central fatty degeneration of the liver were also found microscopically.
These findings showed that this case was a juvenile type of spontaneous diabetes mellitus in a cow.
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