A three-year-old female Japanese indigenous dog displayed typical signs of hypothyroidism, including myxedema, low body temperature, low voltage on ECG and high level of serum cholesterol above 500mg/d
l. The concentrations of serum thyroxine (T
4) and TSH of the patient and control dogs were estimated by a commercial kit of radioimmunoassay.
The level of serum T
4was under 0.1μg/d
lin the patient, and 0.98±0.5, ranging from 0.4 to 2.4, μg/d
l in 10 control dogs. Serum TSH level ranged from 2.7 to 2.9μU/m
lin the patient and from 0.9 to 2.1μU/m
l, averaging 1.66 μ0.4μU/m
l, in 5 control dogs. In the patient, serum levels of both cholesterol and creatine phosphokinase began to decrease after oral administration of thyroid extract, and serum T
4level reached 0.4μg/d
lon the 56th day after the treatment. In the patient and a control dog, the injection of 200μg of thyrotropin-releasing hormone (TRH) did not show apparent increase of their serum TSH level.
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