Thiopronine (2-mercaptopropionylglycine, MPG) was adminitsered to 63 Holstein cows with fatty liver. Of them, 34 were treated with only MPG (50-100ml/time) and 29 with a combination of MPG and some other dugs. As a result, 30 (88.2%) and 18 (62.1%), respectively, showed a clinical improvement with a milk yield recovery, no fatty droplets being detectedfrom the liver. T recovered cows exhibited a reduction in serum NEFA, TG, ALP, T-Bili (p<0.01), and BUN (p<0.05). The poorly miproved cows presented an increase in serum GOT, GPT and γA-GPT (P<0.05).
Rectal basal body temperature (BBT) was taken in 17 Holstein and 11 Japanese Black cows. It decreased before heat, increased on the day of standing heat, and decreased after heat. This pattern of changes was clearly observed when estrus was induced by prostaglandin F2α-analogue (PGa). In cows showing superovulation with folicle stimulating hormone (FSH) BBT decreased for 3 days after heat. BBT fluctuated more obviously in the Japanese than inthe Holstein cows. in the estrous cycle. The highest BBT level was observed on the day of heat in 4 pregnant recipients with an embryo transferred, but not in 7 non-pregnant recipients.
The immunomodulator, Levamisole (LMS) or Klestin (PSK), was administered in dogs after experimental thoracotomy. Lymphocyte blastogenesis was depressed transiently in untreated control dogs up to 3 weeks after surgery. When 2.5mg/kg/day LMS of was administered for 3 consecutive day sper week for 2 weeks, the response of lymphocytes recoverd at the 2nd or 3rd. postoperative week. When lg/day of PSK was given for 2 weeks aftero peration, postoperative suppression of lymphocyte blastogenesis was prevented for a long time. The depressionof lymphocyte response in the PSK group recovered at the 3rd postoperative week. Neither drug influenced the number of lymphocytes or T-cells of the 11-OHCS level. LMS and PSK seemed to have efficacy on the prevention of postoperative immunosuppression, especially the depression of the lymphocyte function.
Three of six cats kept in a house near an auto-repair shop died suddenly at December 16, 1883. Two of the other cats collapsed and died on the next day (No.1 and 2). The other one showed no clinical signs (No.3). No.1, 2, and 3 shhowed azotemia. No.1 got hypocalcemia. A marked deposition of crystals of calcium oxalate and a severe vacuolar degeneration of tubular epithelium were observed in the renal tubules of No.1. Therefore, it was suspected that these cats might have been poisoned with ethylene glycole by ingestion of an antifreeze solution
When 29 male fattening dairy calves were introduced into a farm of 250 cattle, respiratoy symptoms and diarrhea occurred in 64 cattle 9 days later. Tow strains of bovine adenovirustype 3 (BAdV-3) were isolated from nasal secretions of 10 calves with respiratory symptomsand diarrhea by using tissue cultures of bovine kidney cells. Paris of serum samples were collected from 9 calves in the affected heard. Of these calves, six showed a significant rise in antibody titer against (BAdV-3).
At the Ebetsu meat inspection Center, Treponema hyodysenteriae was isolated from the colonic containts and mucosal scrapings of 10 of 14 pigs examined. It ranged from 104 to 107 colony forming units (CFU)/ml. It was also isolated fromthe ceca and rectum within a range from 103 to 106 CFU/ml. Atnecropsy, congestion, diffuse inflammation, ulceration and pseudomembrane were observed inthe colonic mucosa. Of 208 pigs inspected, none showed clinical signs, but 14 had lesions of dysentery in the large intestine.
A survey on fungi and Thermoactinomycetes was carried out on bedding, hay and house dust on 3 dairy farms. Twenty-six species of 17 genera of fungi were isolated from bedding and hay, both of which had been baled with the roll baler, and 25 species of 13 genera of funigfrom house dust.Micropolysporar ubro-rubescenswhich belongs to Thermoactinomyce teswas isolated from house dust on one. Fungi isolated on every farm wereAspergillusf umigatusfrom bedding and hay, andCryptococcus uniguttulatusand Debaryomyces hansenii from house dust. The number of fungi in bedding, hay and house dust was more than104/g. Serologically, the human beings and dairy cows on these farms were found to have no significantly high titers against any particular fungal species and Thermoactinomycetes.
Campylobacter organisms were isolated from 21.5% of human patients with sporadic diarrhea in a city. Most of then belonged to Campylobactejre juni. In the same city this species was isolated from cattle (11.5%), broiler chickens (45.0%), laying hens (18.6%), dogs (3.9%), and cats (9.7%). All the strains isolated from swine were classified into C. coli. C. jejuni was isolated from animals and diarrheal persons all the year round, although it tended to be detected more frequently in such persons and broiler chickens in spring and summer than in any other season. Some serovars of C. jejuni isolated fromcattle, chickens, dogs, and cats were fodnd among the strains of human origin. Broiler chickens carried C. jejuni at a high rate and resembled the human. patients in the serotype pattern and the condition of seasonal isolation. Therefore, they were considered as a very important source of infection for human beings.
A 4-month-old kitten died after exhibiting high fever and respiratory symptoms. Toxoplasmosis was diagnosed in it. Necropsy revealed hydrothorax, edematous lungs, swelling of the liver and lymph nodes, and petechiae of the kidneys. Severe necrotic lesions were seen in the liver and lymph nodes. The epithelial cells of alveoli were enlarged. Tachyzoites ofToxoplasma gondiiwere detected in Giemsa stained stamp smears of lymph nodes, spleen, liver and lungs