On a farm where a diarrheal disease due to Escherichia coli occurred in 59 of 74 sucklings from 8 sows, 49 affected piglets were injected intramuscularly with a fluoroquinolone AT-4526 at a dose of 2.5 or 5 mg/kg/ day for 3-5 days. With 2.5 and 5 mg/kg/day, clinical recovery was observed in 7 of 10 (70%) and 36 of 39 (92.3%) piglets, and the number of E. coli in the rectal feces decreased to less than one tenth in 10 of 10 (100%) and 38 of 39 (97.4%) animals, respectively. The number of E. coli in the rectal swabs remarkably decreased after administration of AT-4526, whereas little effect was seen on Lactobacillus spp. and anaerobic bacteria.
Six goat kids, 12 to 35 days old, from a farm in Tokachi district of Hokkaido, showed recumbency, stiffness, cyanosis and tachycardia as well as markedly increased levels of serum GOT, CPK, LDH, LDH1 and LDH5. Electrocardiogram showed elevation or depression of ST segment and ventricular premature beat. Serum selenium and tocopherol levels were very low. Pathologically, severe degeneration was shown in the skeletal and left ventricular and interventricular muscle.
A 4-day-old female Japanese black and a 5-day-old male Holstein calves showed congenital absence of the spleen, situs inversus of the abdominal viscera, isomeric right lungs, situs inversus of the atria and complex cardiovascular anomalies. In the latter case the right isomeric and symmetric liver was apparent.
A patch graft of glutaraldehyde-preserved canine pericardium was applied for repairing experimental diaphragmatic defect in three feline and one canine cases. One month to one year after the surgical procedure, inflammatory adhesive responses were minimum, followed by unity of graft and recipient tissues. The procedure was proved to be useful also in two feline clinical cases of diaphragmatic hernia.
A 7-year-old female Toy Poodle weighing 2.1kg showed joint swelling and angular deformity with pain and lameness. Radiography revealed luxation with severe destruction of joints and periarticular soft tissue swelling. Hyperglobulinemia with increased levels of alpha2, beta and gammaglobulin fractions was observed. After administrating of bucillamine, an immunomodulator, clinical signs of affected joints were significantly improved in accordance with decreasing gamma globulin, suggesting that immunologic mechanism might be involved in this case of canine rheumatoid arthritis.
In a 2 year and 8 month-old female Golden Retriever dog showing vomiting, decreased appetite and activity, muffled heart sound, inaudible lung sound and acumulation of chest fluid, a large mass occupying the right atrium was detected by radiography and echocardiography. At necropsy, a dark red and soft tumor mass 3.5×3.0×3.5cm in size was found on the tricuspid vulve. Histopathologically, the mass had no heart muscle fibers, and stellate or spindle shaped tumor cells showing no atypia and mitotic figures were scattered in the slightly acidophilic myxomatous matrix with hemorrhage and infiltration of inflammatory cells. It was histopathologically diagnosed as a myxoma in the right atrium.
An 11-year-old female Siba dog had a hard hemisphere nodule 40×30mm in size, radiographically, connecting with the parietal bone. No abnormalities were detected in the other organs including the lung and the nodule was surgically removed. Grossly the nodule was encapsuled by the periosteum and demarcated from adjacent soft tissues, and the cut surface was reddish brown and yellowish brown. Histological diagnosis was multilobular tumor of bone. The recurrence was seen at the operated region, and the case died with abnormal actions about 2 months later.
An outbreak of infection with Salmonella Typhimurium occurred at a nursery school in Gyoda city of Saitama Prefecture in September to October, 1992, appearing to be different from poisoning due to a single food. S. Typhimurium was isolated 20 of 131 (15.2%) children's stools examined, as well as from the sand of the sand pit and the sponge of cleaning mops. The plasmid profiles and antibiotic resistance pattern of the isolates suggested that the sand was possibly source of the infection.