Complementary DNA for the canine quaking gene (
Cqk) and the feline quaking gene (
Fqk), which are homologous with mouse
qkl, were isolated and their nucleotide sequences were determined. At the nucleotide level, sequence data for
Cqk showed very high homology (95.4%) with mouse qkl. The corresponding value for
Fqk was 96.7%. Deduced amino-acid sequences for
Cqk and
Fqk matched that of mouse
qkI perfectly. These findings suggest that the quaking-gene family is highly conserved during mammalian evolution and that
Cqk and
Fqk are likely to fulfill important biological functions in dogs and cats, too.
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