This study investigated immune responses in 5 normal male beagle ranging from 3 to 6 years old orally given an enteric capsulate preparation containing
Bifidobacterium pseudolongum (JPB01). After 30 days, the number and ratio of CD4-positive lymphocytes, the number of CD3-positive lymphocytes, and the ratio of CD4/CD8 positive lymphocytes in peripheral-blood were significantly higher in all 5 dogs than those before inoculation. The number of CD25-positive lymphocytes after the stimulation by mitogen irritants (PHA, ConA and PWM) had increased significantly. No significant difference in granulocyte phagocytosis was observed between pre and post-inoculation. These data suggest that
B. pseudolongum had immunepotentialized lymphocytes.
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