The purpose of this study was to evaluate the relationship between growth and the concentration of insulin -like growth factor (IGF)-1 in Japanese black cattle with growth retardation. The body weight and height ofthe cattle with growth retardation (eight males, eight females, and one castrated) were lower than the control, and the rate of compliance with the Japanese standard for beef cattle were approximately 30% for body weightand approximately 80% for height. The mean daily gain in body weight was approximately 0.3kg, and they didnot show any “catch-up growth”. In addition, serum IGF-1 concentrations at the beginning and end of theobservation period were low. The growth-retarded cattle showing low serum IGF-1 concentration would notbe able to grow, even though they exhibited normal appetite and were in good physical condition. Thus, determinationof serum IGF-1 concentration might be an index of the subsequent growth of the cattle with growthretardation.
There was a high incidence of sudden death due to haemonchosis in a sheep herd, where a regular anthelmicticprogram using diethylcarbamazine had been conducted. When a new anthelmintic program using ivermectin (IVM) or levamisole (LEV) was conducted over three years, the mortality apparently decreased fromapproximately 20% to 2.8% in the third year. The anthelmintic effects were poor with minimal reduction in eggper gram (EPG) in the pour-on route of IVM, but were significantly higher with a major reduction in the average EPG from 5418.5 to 3.2 in the subcutaneous route of IVM and from 98.2 to 1.9 in the oral route of LEV afteradministration for one month. However, the anthelmintic effects after two months of administration in the subcutaneousroute of IVM were lower than those of the one-month interval, in which the reduction of EPG wasfrom 120.5 to 41.1, indicating no significance. Moreover, despite the significantly higher anthelmintic effectsat first administration of both IVM and LEV for each year, the EPGs were gradually decreased after the secondadministration. This may indicate the occurrence of drug-resistant worms.
A female Shetland sheepdog was referred to us suffering from depression, anorexia and bloody diarrhea. Aphysical examination demonstrated abdominal pain. Hematological examination revealed an increase in WBC, and a serum chemistry analysis revealed an increment in serum alkaline phosphatase, amylase and lipase.Serum CRP levels markedly increased at 51mg/dl. The dog was therefore diagnosed as suffering from acutepancreatitis. For primary care, NPO (nothing by mouth) was conducted for three days, and antibiotic andgabexate mesilate were administrated intravenously. On the second day, the WBC and serum lipase increased, but serum CRP levels decreased compared with the first day. After 12 days, the dog was discharged from theveterinary hospital with vitality and appetite restored. In the current case, the measurement of serum CRP levelswas effective in evaluating the condition of acute pancreatitis. Moreover, serial serum CRP measurementswere effective in predicting the efficacy of treatment.
To clarify the causes or triggers of muscular abnormality, including steatosis or muscular dystrophy, in Japanese Black cattle, we investigated the effect of bull strains and the effect of the environment in which thecattle were raised. No specific bulls were identified that were linked to the high incidence of muscular abnormality (1.0% to 6.3% among 10 bulls). However, we found that bull strains were related: the Fujiyoshi-strain andthe Kedaka-strain showed a higher incidence of muscular abnormality than in the Nakadoi-strain. The incidenceof muscular abnormality was low (0% to 5.2%) in cows from the eleven large farms that delivered more than 50cows over the last six months, while it was higher (12.1% to 20.0%) in those from several small farms. Theseresults suggest that both factors, namely the strains and environmental factors might affect the development ofmuscular abnormality in Japanese Black cattle.