Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Volume 62 , Issue 5
Showing 1-8 articles out of 8 articles from the selected issue
The Japanese Society of Farm Animal Veterinary Medicine
The Japanese Society of Small Animal Veterinary Medicine
  • Yuki HOSHINO, Satoshi TAKAGI, Tomohiro OSAKI, Masahiro OKUMURA, Toru ...
    Type: Original Article
    2009 Volume 62 Issue 5 Pages 383-387
    Published: May 20, 2009
    Released: September 03, 2016
    JOURNALS FREE ACCESS
    Autogenous activated lymphocytes were sequentially administered as an adjuvant antitumor therapy to 10 dogs with spontaneous malignant tumors in the Veterinary Teaching Hospital at Hokkaido University. Peripheral blood mononuclear cells from tumor-bearing dogs were proliferated and activated for 14 days in culture using anti-canine CD3 antibody and human recombinant IL-2. The cells obtained were reactivated using IL-2 and human recombinant IFN-α. After sequential administration of these activated lymphocytes, proportions of CD4cells and CD8cells were changed in the peripheral blood in all cases, while serum IFN-γ concentration increased in two cases. These results suggest the possibility of strengthening cell-mediated immunity. The general physical conditions of all 10 patients remained stable, and the patients were comfortable during the entire period of lymphocyte administration. This shows that the quality of life of these tumor-bearing dogs was maintained in a relatively favorable state, with no evidence of any adverse effects in response to the sequential infusion of activated lymphocytes. As an adjuvant antitumor therapy, activated lymphocyte therapy is therefore believed to be applicable to and effective for tumor-bearing animals whose immunity may be somewhat suppressed. This therapy may encourage cell-mediated immunity against tumor growth and distant metastasis.
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  • Yasuhiko TSUCHIDA, Chun-Ho PARK
    Type: Original Article
    2009 Volume 62 Issue 5 Pages 388-394
    Published: May 20, 2009
    Released: September 03, 2016
    JOURNALS FREE ACCESS
    A histopathological study was performed on forty canines diagnosed as having post-operative suture granuloma. Seventeen of the forty cases were Miniature dachshund, twenty-two were male and eighteen female. The median age was 5.04 years. Suture sites were located in the inguinal region, subcutis of the abdomen and the abdominal cavity. Twenty-seven of the forty had been castrated or spayed. More than half of the forty samples were silk sutures, followed by absorbable multifilament sutures. Histopathologically, the lesions mainly consisted of pyogranuloma and necrotizing granuloma that contained suture materials in the center of the lesion. However nodular lesions without sutures were also observed. The lesions were more severe where silk and absorbable multifilament sutures were used than others. In the present study, it was suggested that the frequency of occurrence of suture granuloma differs by suture material and breed, and that the most common cause was a castration or spaying operation.
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  • Moe NAKAYAMA, Takashi MORI, Nao IWATANI, Hiroki SAKAI, Mami MURAKAMI, ...
    Type: Short Communication
    2009 Volume 62 Issue 5 Pages 395-397
    Published: May 20, 2009
    Released: September 03, 2016
    JOURNALS FREE ACCESS
    A nine-year-old intact female Shiba dog with an intrathoracic mass was presented. The radiographs revealed a bulky mass in the abdomen and a precordial mass. Histologically, ovarian dysgerminoma and metastasis to the sternal lymph node were suspected. The dog was treated with cisplatin and radiotherapy. The mass decreased dramatically and was removed surgically after four doses of cisplatin. After the surgery, the dog was treated with etoposide but the treatment was discontinued due to side effects. There have not been any signs of recurrence or metastases during approximately seven months since the surgery.
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  • Shigeki YAMANO, Katsuyuki TANAKA, Miki Nishida, Megumi FUJIWARA, Kayok ...
    Type: Short Communication
    2009 Volume 62 Issue 5 Pages 398-402
    Published: May 20, 2009
    Released: September 03, 2016
    JOURNALS FREE ACCESS
    A seven-year-old spayed female Golden Retriever that presented with dilated cardiomyopathy with fainting episodes was treated with Mexiletine (3 mg/kg, q12 h). The canine achieved remission of the clinical symptoms for more than one year under this treatment regimen. However, when the canine started to have fainting spells again caused by ventricular tachycardia and premature ventricular contraction, the blood concentration of Mexiletine was checked. It was found to be below the effective level. Therefore, the dosing interval was shortened (3 mg/kg, q8 h) to maintain an effective blood concentration of the drug, and the fainting episodes abated. These results suggest that in patients on Mexiletine, the blood concentration of Mexiletine should be measured when indicated by the clinical signs, and the dosage adjusted according to the measurement results.
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