Growth retardation and wasting were observed in 6 of 42 pigs at approximately 40 days of age in a herd with 60 sows. Of these, two pigs developed severe neurological signs and became recumbent four days after the onset. The two pigs with neurological signs and one with wasting were examined to diagnose the disease. On pathological examination, nonsuppurative encephalomyelitis was observed in all three pigs examined,and the histological features and viral antigen of porcine circovirus type 2 (PCV2) were detected in the tonsils, subcutaneous lymph nodes, and mesenteric lymph nodes of all three pigs examined. On microbiological examination, porcine teschovirus (PTV) was isolated from the cerebrum of the two pigs with neurological signs,and porcine enterovirus B (PEV-B) was isolated from the pooled rectum content of the three pigs. The final diagnosis was Teschovirus encephalomyelitis (previously known as enterovirus encephalomyelitis or Teschen/Talfan disease) associated with PCV2 infection, based on the neurological signs, histological features, and virological evidence. In addition, a serological survey by virus neutralization test in 408 porcine sera sampled randomly from 49 farms in Saga prefecture showed that both PTV-1 and PEV-B isolates were highly prevalent among the pig populations in Saga prefecture.
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