Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
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Farm Animal Medicine and Animal Health
  • Diabetes in a Japanese Black Calf with Pancreatic Islet Beta Cell Hypoplasia
    Mikuya IWANAGA, Kazuyoshi TAGAWA, Naoki TERAMOTO, Tomotaka SAIGO, Osam ...
    Article type: Short Communication
    2025 Volume 78 Issue 6 Pages e78-e82
    Published: 2025
    Released on J-STAGE: June 07, 2025
    DOIhttps://doi.org/10.12935/jvma.78.e78
    JOURNAL FREE ACCESS
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    A 49-day-old Japanese Black calf presented with neurological symptoms including lethargy, confusion and occasional tremors, as well as glucosuria and ketonuria. Blood tests showed hyperglycemia, and insulin levels were markedly decreased (＜0.05 ng/ml ). Histopathology revealed that the islets were occupied by cells with round nuclei and pale, slightly acidophilic cytoplasm. Aldehyde fuchsin staining showed no positive islet granules, and immunohistochemistry with anti-insulin antibody revealed the presence of small quantities of insulin antigen in some islets. Based on these results, the calf was diagnosed with diabetes caused by islet beta cell hypoplasia.

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