Immune function is influenced by many exercise conditions, for example, exercise intensity and frequency. In this study, we compared exercise rats that trained for two weeks then exercised exhaustively, with sedentary rats that exercised suddenly and exhaustively on immunoglobulin (Ig) productivity. As a result, in exercised groups, IgA production of mesenteric lymph node (MLN) lymphocytes significantly increased. In the sedentary and exercised groups, Ig production of MLN lymphocytes was tended to decrease by exhaustive exercise. But, in the exercised group, Ig production were maintained higher concentrations than that of the sedentary group. Therefore, we expected that antioxidative ability of rat be enhanced by exercise, and increase Ig production. However, in the exercised groups, lipid peroxide concentration of lymphocyte in culture supernatant was higher value than that of the sedentary groups, and glutathione peroxidase activity in blood was significantly decreased by exhaustive exercise. Thus, training exercise increase Ig productivity and suppress the damage in gut immune system. However, that mechanism may be not related to increase of antioxidative function. On the other hand, oxidative stress by exhaustive exercise may relate to the suppression of Ig productivity. Therefore, it is suggested that the reinforcement and suppression of Ig productivity by exercise are controlled by different mechanism, respectively.
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